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Cited by 543

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

The evolutionary journey of Argonaute proteins

Open access
Swarts, Daan C, Makarova, Kira, Wang, Yanli, Nakanishi, Kotaro, Ketting, René F, Koonin, Eugene V, Patel, Dinshaw J, van der Oost, John·2014·Nature Structural & Molecular Biology

Abstract

Argonaute proteins are conserved throughout all domains of life. Recently characterized prokaryotic Argonaute proteins (pAgos) participate in host defense by DNA interference, whereas eukaryotic Argonaute proteins (eAgos) control a wide range of processes by RNA interference. Here we review molecular mechanisms of guide and target binding by Argonaute proteins, and describe how the conformational changes induced by target binding lead to target cleavage. On the basis of structural comparisons and phylogenetic analyses of pAgos and eAgos, we reconstruct the evolutionary journey of the Argonaute proteins through the three domains of life and discuss how different structural features of pAgos and eAgos relate to their distinct physiological roles.

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Metadata

Authors
Swarts, D. C., Makarova, K., Wang, Y., Nakanishi, K., Ketting, R. F., Koonin, E. V., Patel, D. J., & van der Oost, J.
Venue
Nature Structural & Molecular Biology
Published
2014-09
Volume
21
Issue
9
Pages
743-753
ISSN
  • 1545-9985 (ISSN-L)
  • 1545-9993
OpenAlex
W2068056297
Cited by
543
References
6
FWCI
11.68
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The evolutionary journey of Argonaute proteins. https://app.cochat.ai/papers/10.1038/nsmb.2879
The paper
Swarts, D. C., Makarova, K., Wang, Y., Nakanishi, K., Ketting, R. F., Koonin, E. V., Patel, D. J., & van der Oost, J. (2014). The evolutionary journey of Argonaute proteins. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.2879

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.