The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation
Open accessAbstract
Regulation of stem cell self-renewal versus differentiation is critical for embryonic development and adult tissue homeostasis. Drosophila larval neuroblasts divide asymmetrically to self-renew, and are a model system for studying stem cell self-renewal. Here we identify three mutations showing increased brain neuroblast numbers that map to the aurora-A gene, which encodes a conserved kinase implicated in human cancer. Clonal analysis and time-lapse imaging in aurora-A mutants show single neuroblasts generate multiple neuroblasts (ectopic self-renewal). This phenotype is due to two independent neuroblast defects: abnormal atypical protein kinase C (aPKC)/Numb cortical polarity and failure to align the mitotic spindle with the cortical polarity axis. numb mutant clones have ectopic neuroblasts, and Numb overexpression partially suppresses aurora-A neuroblast overgrowth (but not spindle misalignment). Conversely, mutations that disrupt spindle alignment but not cortical polarity have increased neuroblasts. We conclude that Aurora-A and Numb are novel inhibitors of neuroblast self-renewal and that spindle orientation regulates neuroblast self-renewal.
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Citations
Cites
Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry
Albertson, R., & Doe, C. Q. (2003) · Nature Cell Biology · doi:10.1038/ncb922 · Cited by 269
Self-citation
Cited by
Aurora A kinase (AURKA) in normal and pathological cell division
Nikonova, A. S., Astsaturov, I., Serebriiskii, I. G., Dunbrack, R. L., & Golemis, E. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1073-7 · Cited by 448
The Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila
Bowman, S. K., Rolland, V., Betschinger, J., Kinsey, K. A., Emery, G., & Knoblich, J. A. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.004 · Cited by 444
Aurora-A: the maker and breaker of spindle poles
Barr, A. R., & Gergely, F. (2007) · Journal of Cell Science · doi:10.1242/jcs.013136 · Cited by 441
Neural stem cells: balancing self-renewal with differentiation
Doe, C. Q. (2008) · Development · doi:10.1242/dev.014977 · Cited by 420
Self-citationThe Aurora kinase family in cell division and cancer
Vader, G., & Lens, S. M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.003 · Cited by 417
Metadata
- Authors
- Lee, C.-Y., Andersen, R. O., Cabernard, C., Manning, L., Tran, K. D., Lanskey, M. J., Bashirullah, A., & Doe, C. Q.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-12-15
- Volume
- 20
- Issue
- 24
- Pages
- 3464-3474
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2150968671
- Cited by
- 259
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- The paper
- Lee, C.-Y., Andersen, R. O., Cabernard, C., Manning, L., Tran, K. D., Lanskey, M. J., Bashirullah, A., & Doe, C. Q. (2006). Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes & Development. https://doi.org/10.1101/gad.1489406
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