Hypoxia regulates TSC1/2–mTOR signaling and tumor suppression through REDD1-mediated 14–3–3 shuttling

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

Defining the role of mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797

The Tuberous Sclerosis Complex

Crino, P. B., Nathanson, K. L., & Henske, E. P. (2006) · New England Journal of Medicine · doi:10.1056/nejmra055323 · Cited by 1,793

Growing roles for the mTOR pathway

Sarbassov, D. D., Ali, S. M., & Sabatini, D. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.009 · Cited by 1,590

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384

Gene expression profiling identifies clinically relevant subtypes of prostate cancer

Lapointe, J., Li, C., Higgins, J., van de Rijn, M., Bair, E., Montgomery, K. D., Ferrari, M. K., Egevad, L., Rayford, W., Bergerheim, U. S. R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304146101 · Cited by 1,282

Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition

Damerill, I., Biggar, K. K., Shehab, M. A., Li, S. S. ‐., Jansson, T., & Gupta, M. B. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1194 · Cited by 27

Targeting the mTOR pathway in breast cancer

Liu, J., Li, H., Zhou, F.-X., Yu, J.-W., Sun, L., & Han, Z.-H. (2017) · Tumor Biology · doi:10.1177/1010428317710825 · Cited by 27

Deletion of the glucocorticoid receptor chaperone FKBP51 prevents glucocorticoid-induced skin atrophy

Baida, G. E., Bhalla, P., Yemelyanov, A. Y., Stechschulte, L. A., Shou, W., Readhead, B., Dudley, J. T., Sánchez, E. R., & Budunova, I. V. (2018) · Oncotarget · doi:10.18632/oncotarget.26194 · Cited by 28

Nutrient-Mediated Perception and Signalling in Human Metabolism: A Perspective of Nutrigenomics

Lal, M. K., Sharma, E., Tiwari, R. K., Devi, R., Mishra, U. N., Thakur, R., Gupta, R., Dey, A., Lal, P., Kumar, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911305 · Cited by 30

The role of TSC2 in breast cancer: a literature review

Zhu, Q., He, Z.-M., Cao, W., & Li, B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1188371 · Cited by 26

Zoledronic acid-induced cytotoxicity through endoplasmic reticulum stress triggered REDD1-mTOR pathway in breast cancer cells.

Lan, Y.-C., Chang, C.-L., Sung, M., Yin, P., Hsu, C., Wang, K.-C., Lee, H., Tseng, L., & Chi, C. (2013) · PubMed · Cited by 26

Sustained overexpression of Redd1 leads to Akt activation involved in cell survival

Jin, H., Hong, S., Kim, J., Choi, H.-N., Kim, K., An, S., Choe, T., Hwang, C.-S., Lee, J. H., Kim, J., et al. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.03.021 · Cited by 26

RTP801 immunoreactivity in retinal ganglion cells and its down-regulation in cultured cells protect them from light and cobalt chloride

del Olmo‐Aguado, S., Núñez‐Álvarez, C., Ji, D., Manso, A. G., & Osborne, N. N. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.08.002 · Cited by 26

Hypoxia‐induced regulation of mTOR signaling by miR‐7 targeting REDD1

Seong, M., Lee, J., & Kang, H. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27740 · Cited by 29

Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling

Coyne, E. S., Bedard, N., Wykes, L., Stretch, C., Jammoul, S., Li, S., Zhang, K., SLADEK, R. M., Bathe, O. F., Jagoe, R. T., et al. (2018) · Endocrinology · doi:10.1210/en.2018-00290 · Cited by 28

The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA

Gorbunova, E. E., Simons, M. J., Gavrilovskaya, I. N., & Mackow, E. R. (2016) · mBio · doi:10.1128/mbio.01747-16 · Cited by 25

Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia

Sinha, I., Allen, J. E., Pinto, J. T., & Sinha, R. (2014) · Cancer Medicine · doi:10.1002/cam4.198 · Cited by 25

Beyond Redox Regulation

Li, C., Fang, Y., & Chen, Y. M. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.12.011 · Cited by 24

Hypoxia and gerosuppression: The mTOR saga continues

Leontieva, O. V., & Blagosklonny, M. V. (2012) · Cell Cycle · doi:10.4161/cc.21908 · Cited by 25

Chronic myeloid leukemia progenitor cells require autophagy when leaving hypoxia-induced quiescence

Ianniciello, A., Dumas, P., Drullion, C., Guitart, A. V., Villacreces, A., Peytour, Y., Chevaleyre, J., de la Grange, P. B., Vigon, I., Desplat, V., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18904 · Cited by 26

GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels

Kanno, A., Asahara, S.-I., Furubayashi, A., Masuda, K., Yoshitomi, R., Suzuki, E., Takai, T., Kimura-Koyanagi, M., Matsuda, T., Bartolomé, A., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.128820 · Cited by 24

REDD1 deletion attenuates cancer cachexia in mice

Hain, B. A., Xu, H., VanCleave, A. M., Gordon, B. S., Kimball, S. R., & Waning, D. L. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00536.2021 · Cited by 24

Nutrient weight against sarcopenia: regulation of the IGF-1/PI3K/Akt/FOXO pathway in quinoa metabolites

Liu, P., Hu, Y., Wang, M.-J., & Kang, L. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.10.001 · Cited by 25

Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences

Çam, H., & Houghton, P. J. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0173-x · Cited by 25

Endurance exercise decreases protein synthesis and ER-mitochondria contacts in mouse skeletal muscle

Merle, A., Jollet, M., Britto, F. A., Goustard, B., Bendridi, N., Rieusset, J., Ollendorff, V., & Favier, F. B. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00196.2019 · Cited by 28

Metabolic labeling of RNA uncovers the contribution of transcription and decay rates on hypoxia-induced changes in RNA levels

Tiana, M., Acosta-Iborra, B., Hernández, R., Galiana, C., Fernández-Moreno, M. Á., Jimenez, B., & del Peso, L. (2020) · RNA · doi:10.1261/rna.072611.119 · Cited by 23

A comprehensive review of antitumor properties of Angelica species and their antitumor‐responsible constituents and the underlying molecular mechanisms involved in tumor inhibition

Sabeel, Z., Liang, Y., Hao, M., Lu, Y., Guo, R., Chen, R., Li, X., Yu, C., & Yang, Z. (2023) · Phytotherapy Research · doi:10.1002/ptr.7841 · Cited by 23

Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction

Lane, S. L., Doyle, A. S., Bales, E. S., Lorca, R. A., Julian, C. G., & MOORE, L. G. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz208 · Cited by 23

Sodium bicarbonate, an inorganic salt and a potential active agent for cancer therapy

Wang, Y., Zhou, X., Wang, W., Wu, Y., Qian, Z., & Peng, Q. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.06.032 · Cited by 22

Severe inbreeding, increased mutation load and gene loss-of-function in the critically endangered Devils Hole pupfish

Tian, D., Patton, A. H., Turner, B. J., & Martin, C. H. (2022) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2022.1561 · Cited by 25

mTOR and its tight regulation for iNKT cell development and effector function

Yang, W., Gorentla, B. K., Zhong, X., & Shin, J. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.022 · Cited by 23

A herpesvirus kinase that masquerades as Akt

Chuluunbaatar, U., & Mohr, I. (2011) · Cell Cycle · doi:10.4161/cc.10.13.16242 · Cited by 23

Transcriptional dynamics of immune, growth and stress related genes in skeletal muscle of the fine flounder ( Paralichthys adpersus) during different nutritional statuses

Valenzuela, C., Escobar, D., Perez, L., Zuloaga, R., Estrada, J. M., Mercado, L. A., Valdés, J. A., & Molina, A. (2015) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.06.007 · Cited by 23

REDD1 deficiency protects against nonalcoholic hepatic steatosis induced by high‐fat diet

Dumas, K., Ayachi, C., Gilleron, J., Lacas‐Gervais, S., Pastor, F., Favier, F. B., Peraldi, P., Vaillant, N., Yvan‐Charvet, L., Bonnafous, S., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901799rr · Cited by 23

Protein Phosphorylation as a Key Mechanism of mTORC1/2 Signaling Pathways

Tchevkina, E. M., & Komelkov, A. V. (2012) · InTech eBooks · doi:10.5772/48274 · Cited by 26

Supplementation Strategies for Strength and Power Athletes: Carbohydrate, Protein, and Amino Acid Ingestion

Bird, S. P., Nienhuis, M. B., Biagioli, B., Pauw, K. D., & MEEUSEN, R. R. (2024) · Nutrients · doi:10.3390/nu16121886 · Cited by 27

Stress response regulation of mRNA translation: Implications for antioxidant enzyme expression in cancer

Kim, Y. S., Kimball, S. R., Piskounova, E., Begley, T. J., & Hempel, N. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317846121 · Cited by 24

Cell plasticity in regeneration in the stomach and beyond

Adkins-Threats, M., & Mills, J. C. (2022) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2022.101948 · Cited by 23

Resveratrol improves palmitic acid‑induced insulin resistance via the DDIT4/mTOR pathway in C2C12 cells

Pan, X., Liu, C., Wang, X., Zhao, M., Zhang, Z., Zhang, X., Wang, C., & Song, G. (2023) · Molecular Medicine Reports · doi:10.3892/mmr.2023.13068 · Cited by 22

Redd1 inhibits the invasiveness of non-small cell lung cancer cells

Jin, H., Seo, S., Woo, S., Kim, Y., Hong, S., Yi, J.-Y., Noh, W.-C., Kim, E., Lee, J., Hong, S., et al. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.03.047 · Cited by 23

Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia

Hirao, A., & Hoshii, T. (2013) · Cancer Science · doi:10.1111/cas.12189 · Cited by 24

PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4

Salsman, J., Stathakis, A., Parker, E., Chung, D., Anthes, L. E., Koskowich, K. L., Lahsaee, S., Gaston, D., Kukurba, K. R., Smith, K. S., et al. (2017) · Scientific Reports · doi:10.1038/srep45038 · Cited by 20

Identification of key HIF-1α target genes that regulate adaptation to hypoxic conditions in Tibetan chicken embryos

Zhang, Y., Zhang, H., Zhang, B., Ling, Y., & Zhang, H. (2019) · Gene · doi:10.1016/j.gene.2019.144321 · Cited by 24

Familial Mediterranean fever: the molecular pathways from stress exposure to attacks

Korkmaz, C., Cansu, D. Ü., & Cansu, G. B. (2020) · Rheumatology · doi:10.1093/rheumatology/keaa450 · Cited by 23

Bringing Light to Chronic Obstructive Pulmonary Disease Pathogenesis and Resilience

Tuder, R. M. (2018) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201808-583mg · Cited by 22

mTOR–RAPTOR and 14-3-3σ immunohistochemical expression in high grade prostatic intraepithelial neoplasia and prostatic adenocarcinomas: a tissue microarray study

Evren, S., Dermen, A., Lockwood, G. A., Fleshner, N. E., & Sweet, J. (2011) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2011-200083 · Cited by 21

Origins and molecular effects of hypoxia in cancer

Rey-Keim, S., & Schito, L. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.10.001 · Cited by 22

Changes and expressions of Redd1 in neurons and glial cells in the gerbil hippocampus proper following transient global cerebral ischemia

Lee, C. H., Park, J. H., Cho, J.-H., Ahn, J. H., Yan, B. C., Lee, J., Shin, M. C., Cheon, S. H., Cho, Y. S., Cho, J. H., et al. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.06.016 · Cited by 20

cAMP-PDE signaling in COPD: Review of cellular, molecular and clinical features

Nourian, Y. H., Salimian, J., Ahmadi, A., Salehi, Z., Karimi, M., Emamvirdizadeh, A., Jamalkandi, S. A., & Ghanei, M. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101438 · Cited by 21

Acute hypoxia and reoxygenation alters glucose and lipid metabolic patterns in Hulong hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂)

Wang, T., Zeng, L., Wei, Q., Yang, Y., Tao, Y., Chang, L., Wu, X., Meng, Z., & Liu, X. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.740827 · Cited by 19

Targeting Rb inactivation in cancers by synthetic lethality.

Gordon, G. M., & Du, W. (2011) · PubMed · Cited by 20

Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells

Zhou, Y., Wang, Q., Guo, Z., Weiss, H. L., & Evers, B. M. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-01-0037 · Cited by 22

Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway

Zhou, Y., Wang, Q., Weiss, H. L., & Evers, B. M. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-05-0998 · Cited by 20

Colony, hanging drop, and methylcellulose three dimensional hypoxic growth optimization of renal cell carcinoma cell lines

Matak, D., Brodaczewska, K. K., Lipiec, M., Szymański, Ł., Szczylik, C. A., & Czarnecka, A. M. (2017) · Cytotechnology · doi:10.1007/s10616-016-0063-2 · Cited by 21

APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition

Tiwarekar, V., Wohlfahrt, J., Fehrholz, M., Scholz, C. J., Kneitz, S., & Schneider‐Schaulies, J. (2018) · Journal of Virology · doi:10.1128/jvi.00835-18 · Cited by 20

REDD1 overexpression in oral squamous cell carcinoma may predict poor prognosis and correlates with high microvessel density

Feng, Y., Song, K., Shang, W., Chen, L., Wang, C., Pang, B., & Wang, N. (2019) · Oncology Letters · doi:10.3892/ol.2019.11070 · Cited by 20

Caloric Restriction Normalizes Obesity‐Induced Alterations on Regulators of Skeletal Muscle Growth Signaling

Dungan, C. M., Li, J., & Williamson, D. L. (2016) · Lipids · doi:10.1007/s11745-016-4168-3 · Cited by 20

Expression of inhibitor proteins that control primordial follicle reserve decreases in cryopreserved ovaries after autotransplantation

Celik, S., Celikkan, F. T., Özkavukçu, S., Can, A., & Çelik-Özenci, Ç. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1140-6 · Cited by 19

Severe energy deficit at high altitude inhibits skeletal muscle mTORC1‐mediated anabolic signaling without increased ubiquitin proteasome activity

Margolis, L. M., Carbone, J. W., Berryman, C. E., Carrigan, C. T., Murphy, N. E., Ferrando, A. A., Young, A., & Pasiakos, S. M. (2018) · The FASEB Journal · doi:10.1096/fj.201800163rr · Cited by 19

Serum interferon alpha receptor 2 mRNA may predict efficacy of interferon alpha with/without low-dose sorafenib for metastatic clear cell renal cell carcinoma

Furuya, N., Kamai, T., Shirataki, H., Yanai, Y., Fukuda, T., Mizuno, T., Nakamura, F., Kambara, T., Nakanishi, K., Abe, H., et al. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-0989-3 · Cited by 18

Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD–Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway

Nogami, A., Okada, K., Ishida, S., Akiyama, H., Umezawa, Y., & Miura, O. (2018) · Translational Oncology · doi:10.1016/j.tranon.2018.11.001 · Cited by 18

Acute normobaric hypoxia blunts contraction‐mediated mTORC1‐ and JNK‐signaling in human skeletal muscle

Moberg, M., Apró, W., Horwath, O., van Hall, G., Blackwood, S. J., & Katz, A. (2022) · Acta Physiologica · doi:10.1111/apha.13771 · Cited by 17

p53 promote oxidative stress, neuroinflammation and behavioral disorders via DDIT4-NF-κB signaling pathway

Zhang, K., Zhao, Y., Chen, X., Li, Y., Lan, T., Chang, M., Wang, W., Wang, C., Zhuang, X., Zhang, B., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103836 · Cited by 21

REDD1 is a determinant of low-dose metronomic doxorubicin-elicited endothelial cell dysfunction through downregulation of VEGFR-2/3 expression

Park, M., Kim, J., Kim, T., Kim, S., Park, W., Ha, K., Cho, S. H., Won, M., Lee, J., Kwon, Y., et al. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00690-z · Cited by 17

VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α

Yue, Y., Tang, Y., Huang, H., Zheng, D., Liu, C., Zhang, H., Liu, Y., Li, Y., Sun, X., & Lu, L. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104829 · Cited by 17

Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects

Hu, J., Fu, S., Zhan, Z., & Zhang, J. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116109 · Cited by 19

p53 Orchestrates Cancer Metabolism: Unveiling Strategies to Reverse the Warburg Effect

Abukwaik, R., Vera-Sigüenza, E., Tennant, D. A., & Spill, F. (2024) · Bulletin of Mathematical Biology · doi:10.1007/s11538-024-01346-5 · Cited by 19

Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells

Whirledge, S., Kisanga, E. P., Taylor, R. N., & Cidlowski, J. A. (2017) · Endocrinology · doi:10.1210/en.2017-00361 · Cited by 17

Acute treadmill exercise discriminately improves the skeletal muscle insulin-stimulated growth signaling responses in mice lacking REDD1

Dungan, C. M., Gordon, B. S., & Williamson, D. L. (2019) · Physiological Reports · doi:10.14814/phy2.14011 · Cited by 16

DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation

Evagelou, S. L., Bebenek, O., Specker, E. J., & Uniacke, J. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00610-19 · Cited by 20

Tumor hypoxia and genetic alterations in sporadic cancers

Koi, M., & Boland, C. R. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2010.01377.x · Cited by 17

Inhibition of mTORC1 activity by REDD1 induction in myeloma cells resistant to bortezomib cytotoxicity

Decaux, O., Clément, M., Magrangeas, F., Gouraud, W., Guérin‐Charbonnel, C., Campion, L., Avet‐Loiseau, H., & Minvielle, S. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01467.x · Cited by 22

Bridging pathway dysfunction and therapy: novel compounds for neuroprotection

Patel, S., Prajapati, C., Nand, S., & Singh, S. K. (2026) · 3 Biotech · doi:10.1007/s13205-026-04697-z · Cited by 16

Autophagy regulated by the HIF/REDD1/mTORC1 signaling is progressively increased during erythroid differentiation under hypoxia

Li, J., Quan, C., He, Y., Cao, Y., Chen, Y., Wang, Y., & Wu, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.896893 · Cited by 17

Immunohistochemical examination of the mTORC1 pathway in high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinomas (PCa): A tissue microarray study (TMA)

Evren, S., Dermen, A., Lockwood, G., Fleshner, N. E., & Sweet, J. (2010) · The Prostate · doi:10.1002/pros.21178 · Cited by 16

Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) Microenvironment

Liang, S., Galluzzo, P., Sobol, A., Skucha, S., Rambo, B., & Bocchetta, M. (2012) · Genes & Cancer · doi:10.1177/1947601912457025 · Cited by 16

Alteration of REDD1-Mediated Mammalian Target of Rapamycin Pathway and Hypoxia-Inducible Factor-1α Regulation in Human Breast Cancer

Koo, J. S., & Jung, W. (2010) · Pathobiology · doi:10.1159/000320936 · Cited by 16

Effects of the single and combined treatment with dopamine agonist, somatostatin analog and mTOR inhibitors in a human lung carcinoid cell line: an in vitro study

Pivonello, C., Rousaki, P., Negri, M., Sarnataro, M., Napolitano, M., Marino, F. Z., Patalano, R., Martino, M. C. D., Sciammarella, C., Faggiano, A., et al. (2016) · Endocrine · doi:10.1007/s12020-016-1079-2 · Cited by 16

Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Maintenance by the PI3K-mTORC1 Pathway

Ghosh, J., & Kapur, R. (2016) · Current Stem Cell Reports · doi:10.1007/s40778-016-0067-z · Cited by 15

Could metformin be therapeutically useful in Huntington’s disease?

Tang, B. L. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0072 · Cited by 15

Low-dose metronomic doxorubicin inhibits mobilization and differentiation of endothelial progenitor cells through REDD1-mediated VEGFR-2 downregulation

Park, M., Kim, J. Y., Kim, J., Lee, J., Kwon, Y., & Kim, Y. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.9.096 · Cited by 15

Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia

Uchenunu, O., Pollak, M., Topisirović, I., & Hulea, L. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0058 · Cited by 16

Hepatic Endoderm Differentiation from Human Embryonic Stem Cells

Hannoun, Z., Filippi, C., Sullivan, G. J., Hay, D. C., & Iredale, J. P. (2010) · Current Stem Cell Research & Therapy · doi:10.2174/157488810791824403 · Cited by 14

mTORC2 Is Activated under Hypoxia and Could Support Chronic Myeloid Leukemia Stem Cells

Panuzzo, C., Pironi, L., Maglione, A., Rocco, S., Stanga, S., Riganti, C., Kopecka, J., Ali, M. S., Pergolizzi, B., Bracco, E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021234 · Cited by 14

Up-Regulation of miR-9-5p Inhibits Hypoxia-Ischemia Brain Damage Through the DDIT4-Mediated Autophagy Pathways in Neonatal Mice

Gai, C., Xing, X., Song, Y., Zhao, Y., Jiang, Z., Cheng, Y., Xiao, Y., & Wang, Z. (2023) · Drug Design, Development and Therapy · doi:10.2147/dddt.s393362 · Cited by 14

Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression

Wang, Y., Engel, T., & Teng, X. (2024) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2024.195005 · Cited by 13

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Qaid, E. Y. A., Zulkipli, N. N., Zakaria, R., Ahmad, A. H., Othman, Z., Muthuraju, S., & Sasongko, T. H. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1746308 · Cited by 13

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Luo, J., Odaka, Y., Huang, Z., Cheng, B., Liu, W., Li, L., Shang, C., Zhang, C., Wu, Y., Luo, Y., et al. (2021) · Cells · doi:10.3390/cells10061363 · Cited by 13

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Saliu, T. P., Kumrungsee, T., Miyata, K., Tominaga, H., Yazawa, N., Hashimoto, K., Kamesawa, M., & Yanaka, N. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120183 · Cited by 13

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Ellisen, L. W. (2010) · Nature Medicine · doi:10.1038/nm0710-754 · Cited by 13

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Vaiou, M., Pangou, E., Liakos, P., Sakellaridis, N., Vassilopoulos, G., DIMAS, K. S., & Papandreou, C. N. (2016) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-016-2216-2 · Cited by 13

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Kumar, P., Zadjali, F., Yao, Y., Johnson, D. L., Siroky, B. J., Astrinidis, A., Vogel, P., Gross, K. W., & Bissler, J. J. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.03.010 · Cited by 13

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Ramlaul, K., & Aylett, C. H. S. (2018) · Frontiers in Biology · doi:10.1007/s11515-018-1501-7 · Cited by 12

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Sauvé, F., Gomez-Martínez, R., Mbouamboua, Y., Ternier, G., Nampoothiri, S. S., Dupré, E., Garcia, L., Couralet, M., Dewisme, J., Lebouvier, T., et al. (2026) · Cell Press Blue · doi:10.1016/j.cpblue.2026.100003 · Cited by 15

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Derr, R. S., Moelijker, N., Hendriks, G., & Brandsma, I. (2022) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2022.105120 · Cited by 12

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Alboushi, L., Hackett, A. P., Naeli, P., Bakhti, M., & Jafarnejad, S. M. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110037 · Cited by 13

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Li, J., Gong, S.-H., He, Y., Cao, Y., Chen, Y., Huang, G.-H., Wang, Y., Zhao, M., Cheng, X., Zhou, Y., et al. (2022) · Stem Cells · doi:10.1093/stmcls/sxac076 · Cited by 12

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Cuesta, R., Gupta, M., & Schneider, R. J. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)90007-2 · Cited by 12

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Brugarolas, J. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-271-1_4 · Cited by 4

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McCarthy, N. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1517 · Cited by 1

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Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384

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Wolff, N. C., Vega-Rubín-de-Celis, S., Xie, X., Castrillón, D. H., Kabbani, W., & Brugarolas, J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01393-10 · Cited by 86

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Vadysirisack, D. D., & Ellisen, L. W. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-430-8_4 · Cited by 49