Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

Yeoh, A. E. J., Ross, M. E., Shurtleff, S. A., Williams, W. K., Patel, D. H., Mahfouz, R. A., Behm, F. G., Raimondi, S. C., Relling, M. V., Patel, A. R., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00032-6 · Cited by 1,914

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

Armstrong, S. A., Staunton, J. E., Silverman, L. B., Pieters, R., den Boer, M. L., Minden, M. D., Sallan, S. E., Lander, E. S., Golub, T. R., & Korsmeyer, S. J. (2001) · Nature Genetics · doi:10.1038/ng765 · Cited by 1,721

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

Hope, K. J., Jin, L., & Dick, J. E. (2004) · Nature Immunology · doi:10.1038/ni1080 · Cited by 986

Altered Hox expression and segmental identity in Mll-mutant mice

Yu, B., Hess, J. L., Horning, S. E., Brown, G. A. J., & Korsmeyer, S. J. (1995) · Nature · doi:10.1038/378505a0 · Cited by 872

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

Kroon, E., Krosl, J., Thorsteinsdottir, U., Baban, S., Buchberg, A. M., & Sauvageau, G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3714 · Cited by 640

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia

Somervaille, T. C. P., & Cleary, M. L. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.020 · Cited by 582

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

Iwama, A., Oguro, H., Negishi, M., Kato, Y., Morita, Y., Tsukui, H., Ema, H., Kamijo, T., Katoh-Fukui, Y., Koseki, H., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.11.004 · Cited by 515

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

Miyamoto, T., Weissman, I. L., & Akashi, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7521 · Cited by 465

Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia

Taussig, D. C. (2005) · Blood · doi:10.1182/blood-2005-03-1072 · Cited by 379

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

Ferrando, A. A., Armstrong, S. A., Neuberg, D. S., Sallan, S. E., Silverman, L. B., Korsmeyer, S. J., & Look, A. T. (2003) · Blood · doi:10.1182/blood-2002-10-3221 · Cited by 350

Meis1, a PBX1-Related Homeobox Gene Involved in Myeloid Leukemia in BXH-2 Mice

Moskow, J. J., Bullrich, F., Huebner, K., Daar, I. O., & Buchberg, A. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5434 · Cited by 335

Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization

Zeisig, B. B., Milne, T., García-Cuéllar, M.-P., Schreiner, S., Martin, M.-E., Fuchs, U., Borkhardt, A., Chanda, S. K., Walker, J. R., Soden, R., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.617-628.2004 · Cited by 330

Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

Hisa, T., Spence, S. E., Rachel, R. A., Fujita, M., Nakamura, T., Ward, J. M., Devor-Henneman, D. E., Saiki, Y., Kutsuna, H., Tessarollo, L., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600038 · Cited by 306

MLL, a mammalian trithorax- group gene, functions as a transcriptional maintenance factor in morphogenesis

Yu, B., Hanson, R. D., Hess, J. L., Horning, S. E., & Korsmeyer, S. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10632 · Cited by 302

Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

Pineault, N., Helgason, C. D., Lawrence, H. J., & Humphries, R. K. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00757-3 · Cited by 278

AbdB-Like Hox Proteins Stabilize DNA Binding by the Meis1 Homeodomain Proteins

Shen, W.-F., Montgomery, J. C., Rozenfeld, S. B., Moskow, J. J., Lawrence, H. J., Buchberg, A. M., & Largman, C. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6448 · Cited by 278

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potentialPreprint

Wong, P., 岩崎, 正., Somervaille, T. C. P., So, C. W. E., & Cleary, M. L. (2007) · Genes & Development · doi:10.1101/gad.1602107 · Cited by 274

HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells

Shen, W.-F., Rozenfeld, S., Kwong, A., Kömüves, L. G., Lawrence, H. J., & Largman, C. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.3051 · Cited by 249

Most Acute Myeloid Leukemia Progenitor Cells With Long-Term Proliferative Ability In Vitro and In Vivo Have the Phenotype CD34+/CD71−/HLA-DR−

Blair, A., Hogge, D. E., & Sutherland, H. J. (1998) · Blood · doi:10.1182/blood.v92.11.4325 · Cited by 239

NUP98–HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice

KROON, E. J., Þorsteinsdóttir, U., Mayotte, N., Nakamura, T., & Sauvageau, G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.3.350 · Cited by 225

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

Kawagoe, H., Humphries, R. K., Blair, A., Sutherland, H., & Hogge, D. E. (1999) · Leukemia · doi:10.1038/sj.leu.2401410 · Cited by 222

Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation

Caslini, C., Yang, Z., El-Osta, M., Milne, T. A., Slany, R. K., & Hess, J. L. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2369 · Cited by 217

Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications

Milne, T. A., Martin, M. E., Brock, H. W., Slany, R. K., & Hess, J. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1041 · Cited by 186

Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality

Rozovskaia, T., Feinstein, E., Mor, O., Foà, R., Blechman, J. A., Nakamura, T., Croce, C. M., Cimino, G. G., & Canaani, E. (2001) · Oncogene · doi:10.1038/sj.onc.1204174 · Cited by 181

c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells

Hess, J. L., Bittner, C. B., Zeisig, D. T., Bach, C., Fuchs, U., Borkhardt, A., Frampton, J., & Slany, R. K. (2006) · Blood · doi:10.1182/blood-2005-12-5014 · Cited by 165

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1

Pineault, N., Buske, C., Feuring‐Buske, M., Abramovich, C., Rosten, P., Hogge, D. E., Aplan, P. D., & Humphries, R. K. (2003) · Blood · doi:10.1182/blood-2002-08-2484 · Cited by 148

Molecular characterization of acute leukemias by use of microarray technology

Kohlmann, A., Schoch, C., Schnittger, S., Dugas, M., Hiddemann, W., Kern, W., & Haferlach, T. (2003) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10225 · Cited by 145

HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo

Fischbach, N. A., Rozenfeld, S. B., Shen, W.-F., Fong, S., Chrobak, D., Ginzinger, D. G., Kogan, S. C., Radhakrishnan, A., Beau, M. M. L., Largman, C., et al. (2004) · Blood · doi:10.1182/blood-2004-04-1583 · Cited by 143

The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis

Daser, A., & Rabbitts, T. H. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.01.007 · Cited by 131

Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus

Wang, G. G., Pasillas, M. P., & Kamps, M. P. (2005) · Blood · doi:10.1182/blood-2004-12-4664 · Cited by 122

Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1

Calvo, K. R., Sykes, D. B., Pasillas, M. P., & Kamps, M. P. (2002) · Oncogene · doi:10.1038/sj.onc.1205516 · Cited by 120

Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothoraxPreprint

Noro, B., Culí, J., McKay, D. J., Zhang, W., & Mann, R. S. (2006) · Genes & Development · doi:10.1101/gad.1412606 · Cited by 114

Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia

Fine, B. M., Stanulla, M., Schrappe, M., Ho, M., Viehmann, S. F., Harbott, J., & Boxer, L. M. (2003) · Blood · doi:10.1182/blood-2003-05-1518 · Cited by 108

Persistent Transactivation by Meis1 Replaces Hox Function in Myeloid Leukemogenesis Models: Evidence for Co-Occupancy of Meis1-Pbx and Hox-Pbx Complexes on Promoters of Leukemia-Associated Genes

Wang, G. G., Pasillas, M. P., & Kamps, M. P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3902-3916.2006 · Cited by 97

Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1

Pineault, N., Abramovich, C., Ohta, H., & Humphries, R. K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1907-1917.2004 · Cited by 91

The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia.

Braekeleer, M. D., Morel, F., Bris, M. L., Herry, A., & Douet‐Guilbert, N. (2005) · PubMed · Cited by 90

Frequent co‐expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement

Imamura, T., Morimoto, A., Takanashi, M., Hibi, S., Sugimoto, T., Ishii, E., & Imashuku, S. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03803.x · Cited by 82

Two distinct gene expression signatures in pediatric acute lymphoblastic leukemia with MLL rearrangements.

Tsutsumi, S., Taketani, T., Nishimura, K., Ge, X., Taki, T., Sugita, K., Ishii, E., Hanada, R., Ohki, M., Aburatani, H., et al. (2003) · PubMed · Cited by 81

The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia

Palmqvist, L., Argiropoulos, B., Pineault, N., Abramovich, C., Sly, L. M., Krystal, G., Wan, A., & Humphries, R. K. (2006) · Blood · doi:10.1182/blood-2005-12-007005 · Cited by 62

Expression ofHOXGenes in Acute Leukemia Cell Lines with and withoutMLLTranslocations

Quentmeier, H., Dirks, W. G., MacLeod, R. A. F., Reinhardt, J., Zaborski, M., & Drexler, H. G. (2003) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190310001609942 · Cited by 59

Molecular Pathogenesis of MLL-Associated Leukemias

Eguchi, M., Eguchi‐Ishimae, M., & Greaves, M. F. (2005) · International Journal of Hematology · doi:10.1532/ijh97.05042 · Cited by 50

Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation

Mamo, A. (2006) · Blood · doi:10.1182/blood-2005-06-2244 · Cited by 49

Transplantable cell lines generated with NUP98–Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA

Pineault, N., Abramovich, C., & Humphries, R. K. (2005) · Leukemia · doi:10.1038/sj.leu.2403696 · Cited by 38

The hunt for cancer-initiating cells: a history stemming from leukemia

Buzzeo, M. P., Scott, E. W., & Cogle, C. R. (2007) · Leukemia · doi:10.1038/sj.leu.2404768 · Cited by 36

Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation

Morgado, E., Albouhair, S., & Lavau, C. (2007) · Blood · doi:10.1182/blood-2006-01-039586 · Cited by 28

True

(1999) · Leukemia · doi:10.1038/sj/leu/2401410 · Cited by 6

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Simsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. C., & Sadek, H. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.011 · Cited by 1,101

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

Burslem, G. M., & Crews, C. M. (2020) · Cell · doi:10.1016/j.cell.2019.11.031 · Cited by 1,079

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

Novershtern, N., Subramanian, A., Lawton, L. N., Mak, R. H., Haining, W. N., McConkey, M. E., Habib, N., Yosef, N., Chang, C. Y., Shay, T., et al. (2011) · Cell · doi:10.1016/j.cell.2011.01.004 · Cited by 942

Meis1 regulates postnatal cardiomyocyte cell cycle arrest

Mahmoud, A. I., Kocabaş, F., Muralidhar, S. A., Kimura, W., Koura, A. S., Thet, S., Porrello, E. R., & Sadek, H. A. (2013) · Nature · doi:10.1038/nature12054 · Cited by 565

EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cellsPreprint

Riggi, N., Suvà, M.-L., Vito, C. D., Provero, P., Stehle, J., Baumer, K., Cironi, L., Janiszewska, M., Petricevic, T., Suvà, D., et al. (2010) · Genes & Development · doi:10.1101/gad.1899710 · Cited by 281

Progress in the role of MEIS1 in MLL-association leukemia

刘琳, 叶启东, & 汤静燕 (2009) · International journal of pediatrics · doi:10.3760/cma.j.issn.1673-4408.2009.06.006

Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3

Argiropoulos, B., Palmqvist, L., Yung, E., Kuchenbauer, F. C., Heuser, M., Sly, L. M., Wan, A. N. C., Krystal, G., & Humphries, R. K. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.02.011 · Cited by 64

Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus

Wang, G. G., Pasillas, M. P., & Kamps, M. P. (2005) · Blood · doi:10.1182/blood-2004-12-4664 · Cited by 122

Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation

Cai, M., Langer, E. M., Gill, J. G., Satpathy, A. T., Albring, J. C., Wumesh, K. C., Murphy, T. L., & MURPHY, K. M. M. (2012) · Blood · doi:10.1182/blood-2012-01-403139 · Cited by 53

Identification of Meis1 Target Genes Involved in the Induction of AML in Collaboration with NUP98-HOXD13.

Palmqvist, L., Argiropoulos, B., & Humphries, R. K. (2006) · Blood · doi:10.1182/blood.v108.11.1404.1404