The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
Open accessAbstract
Common molecular machineries between hematopoietic stem cell (HSC) maintenance and leukemia prevention have been highlighted. The tumor suppressor Fbxw7 (F-box and WD-40 domain protein 7), a subunit of an SCF-type ubiquitin ligase complex, induces the degradation of positive regulators of the cell cycle. We demonstrate that inactivation of Fbxw7 in hematopoietic cells causes premature depletion of HSCs due to active cell cycling and p53-dependent apoptosis. Interestingly, Fbxw7 deletion also confers a selective advantage to cells with suppressed p53 function, eventually leading to development of T-cell acute lymphoblastic leukemia (T-ALL). Thus, Fbxw7 functions as a fail-safe mechanism against both premature HSC loss and leukemogenesis.
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Citations
Cites
FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
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Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
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“Recent studies have demonstrated that it is crucial for hematopoietic stem cells (HSCs) to be quiescent for protection against oxidative stress and to sustain self-renewal capacity (Ito et al. 2004; Tothova et al. 2007).”
BackgroundSelf-citationDisruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
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Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
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Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
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Self-citationChromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
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Cited by
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Suda, T., Takubo, K., & Semenza, G. L. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.09.010 · Cited by 844
Self-citationSCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
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Self-citationTumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities
Davis, R. J., Welcker, M., & Clurman, B. E. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.013 · Cited by 343
Metadata
- Authors
- Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y., Hata, A., Chiba, S., Nakayama, K. I., & Suda, T.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-03-26
- Volume
- 22
- Issue
- 8
- Pages
- 986-991
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2132230421
- Cited by
- 185
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- diamond
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- The paper
- Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., . . . Suda, T. (2008). Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes & Development. https://doi.org/10.1101/gad.1621808
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
