Cited by 844Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

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Suda, Toshio, Takubo, Keiyo, Semenza, Gregg L.·2011·Cell Stem Cell

Abstract

Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone marrow environment, and their metabolic status is distinct from that of their differentiated progeny. HSCs generate energy mainly via anaerobic metabolism by maintaining a high rate of glycolysis. This metabolic balance promotes HSC maintenance by limiting the production of reactive oxygen species, but leaves HSCs susceptible to changes in redox status. In this review, we discuss the importance of oxygen homeostasis and energy metabolism for maintenance of HSC function and long-term self-renewal.

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Crossref · 10.1016/j.stem.2011.09.010

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140 of 140 references verified0 citation errors · 0 not checkable

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Authors
Suda, T., Takubo, K., & Semenza, G. L.
Affiliations
  • Keio University (JP)
  • Johns Hopkins University (US)
Corresponding author
Suda, Toshio
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2011-10
Volume
9
Issue
4
Pages
298-310
ISSN
  • 1875-9777 (ISSN-L)
  • 1934-5909
OpenAlex
W1995091371
Cited by
844
References
140
Citations by year
2026: 37 · 2025: 28 · 2024: 71 · 2023: 55 · 2022: 51 · 2021: 66 · 2020: 60 · 2019: 69 · 2018: 77 · 2017: 63 · 2016: 51 · 2015: 74 · 2014: 59 · 2013: 55 · 2012: 26
FWCI
5.97
Type
journal article
Language
en
Open access
Locations
  • Cell stem cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (23249053, 23689049)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
hematopoietic stem cells, hypoxic niche, bone marrow, glycolysis, anaerobic metabolism, oxygen homeostasis, energy metabolism, reactive oxygen species, redox state, HSC self-renewal, HSC maintenance
MeSH terms
Cell Cycle, Hematopoietic Stem Cells, Humans, Signal Transduction, Cell Hypoxia, Stem Cell Niche, Cellular Microenvironment

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