Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Open accessAbstract
Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone marrow environment, and their metabolic status is distinct from that of their differentiated progeny. HSCs generate energy mainly via anaerobic metabolism by maintaining a high rate of glycolysis. This metabolic balance promotes HSC maintenance by limiting the production of reactive oxygen species, but leaves HSCs susceptible to changes in redox status. In this review, we discuss the importance of oxygen homeostasis and energy metabolism for maintenance of HSC function and long-term self-renewal.
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The level of HIF1α is important for HSC quiescence.
“The level of HIF1α is important for HSC quiescence115.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [115]
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- Authors
- Suda, T., Takubo, K., & Semenza, G. L.
- Affiliations
- Keio University (JP)
- Johns Hopkins University (US)
- Corresponding author
- Suda, Toshio
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 9
- Issue
- 4
- Pages
- 298-310
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1995091371
- Cited by
- 844
- References
- 140
- Citations by year
- 2026: 37 · 2025: 28 · 2024: 71 · 2023: 55 · 2022: 51 · 2021: 66 · 2020: 60 · 2019: 69 · 2018: 77 · 2017: 63 · 2016: 51 · 2015: 74 · 2014: 59 · 2013: 55 · 2012: 26
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23249053, 23689049)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- hematopoietic stem cells, hypoxic niche, bone marrow, glycolysis, anaerobic metabolism, oxygen homeostasis, energy metabolism, reactive oxygen species, redox state, HSC self-renewal, HSC maintenance
- MeSH terms
- Cell Cycle, Hematopoietic Stem Cells, Humans, Signal Transduction, Cell Hypoxia, Stem Cell Niche, Cellular Microenvironment
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