The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
Open accessAbstract
Arteries, veins, and lymphatic vessels are functionally linked, and their physical interaction is tightly regulated. The lymphatic vessels communicate with the blood vessels only at the junction of the jugular and subclavian veins. Here, we characterize the embryonic lymphovenous valves controlling this vital communication and show that they are formed by the intercalation of lymphatic endothelial cells (LECs) with a subpopulation of venous endothelial cells (ECs) at the junction of the jugular and subclavian veins. We found that unlike LEC progenitors, which move out from the veins and differentiate into mature LECs, these Prox1-expressing ECs remain in the veins and do not acquire LEC features. We demonstrate that the development of this Prox1-expressing venous EC population, and therefore of lymphovenous valves, requires two functional copies of Prox1, as the valves are absent in Prox1 heterozygous mice. We show that this is due to a defect in the maintenance of Prox1 expression in venous ECs and LEC progenitors promoted by a reduction in Coup-TFII/Prox1 complex formation. This is the first report describing the molecular mechanism controlling lymphovenous communication.
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Cites
A global double-fluorescent Cre reporter mouse
Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491
Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
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Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis
Bazigou, E., Xie, S., Chen, C., Weston, A., Miura, N., Sorokin, L., Adams, R., Muro, A. F., Sheppard, D., & Makinen, T. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.017 · Cited by 347
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Cited by
Cardiac lymphatics are heterogeneous in origin and respond to injury
Klotz, L., Norman, S., Vieira, J. M., Masters, M., Rohling, M., Dubé, K. N., Bollini, S., Matsuzaki, F., Carr, C. A., & Riley, P. R. (2015) · Nature · doi:10.1038/nature14483 · Cited by 506
Lymphatic pumping: mechanics, mechanisms and malfunction
Scallan, J. P., Zawieja, S. D., Castorena‐Gonzalez, J. A., & Davis, M. J. (2016) · The Journal of Physiology · doi:10.1113/jp272088 · Cited by 424
Sabine, A., Agalarov, Y., Maby-El Hajjami, H., Jaquet, M., Hägerling, R., Pollmann, C., Bebber, D., Pfenniger, A., Miura, N., Dormond, O., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.020 · Cited by 411
Lymphatic Vessel Network Structure and Physiology
Breslin, J. W., Yang, Y., Scallan, J. P., Sweat, R. S., Adderley, S. P., & Murfee, W. L. (2018) · Comprehensive Physiology · doi:10.1002/cphy.c180015 · Cited by 341
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy
Hägerling, R., Pollmann, C., Andreas, M., Schmidt, C., Nurmi, H., Adams, R. H., Alitalo, K., Andresen, V., Schulte-Merker, S., & Kiefer, F. (2013) · The EMBO Journal · doi:10.1038/emboj.2012.340 · Cited by 288
Metadata
- Authors
- Srinivasan, R. S., & Oliver, G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-10-15
- Volume
- 25
- Issue
- 20
- Pages
- 2187-2197
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2055987072
- Cited by
- 166
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Srinivasan, R. S., & Oliver, G. (2011). Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes & Development. https://doi.org/10.1101/gad.16974811
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