The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for β-catenin
Open accessAbstract
Vertebrate muscle arises sequentially from embryonic, fetal, and adult myoblasts. Although functionally distinct, it is unclear whether these myoblast classes develop from common or different progenitors. Pax3 and Pax7 are expressed by somitic myogenic progenitors and are critical myogenic determinants. To test the developmental origin of embryonic and fetal myogenic cells in the limb, we genetically labeled and ablated Pax3+ and Pax7+ cells. Pax3+Pax7− cells contribute to muscle and endothelium, establish and are required for embryonic myogenesis, and give rise to Pax7+ cells. Subsequently, Pax7+ cells give rise to and are required for fetal myogenesis. Thus, Pax3+ and Pax7+ cells contribute differentially to embryonic and fetal limb myogenesis. To investigate whether embryonic and fetal limb myogenic cells have different genetic requirements we conditionally inactivated or activated β-catenin, an important regulator of myogenesis, in Pax3- or Pax7-derived cells. β-Catenin is necessary within the somite for dermomyotome and myotome formation and delamination of limb myogenic progenitors. In the limb, β-catenin is not required for embryonic myoblast specification or myofiber differentiation but is critical for determining fetal progenitor number and myofiber number and type. Together, these studies demonstrate that limb embryonic and fetal myogenic cells develop from distinct, but related progenitors and have different cell-autonomous requirements for β-catenin.
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Cites
Brack, A. S., Conboy, I. M., Conboy, M. J., Shen, J., & Rando, T. A. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.10.006 · Cited by 682
Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex
McKinnell, I. W., Ishibashi, J., Le Grand, F., Punch, V. G. J., Addicks, G. C., Greenblatt, J. F., Dilworth, F. J., & Rudnicki, M. A. (2008) · Nature Cell Biology · doi:10.1038/ncb1671 · Cited by 380 · cited 1×
“However, others found that Tcf/Lef signaling inhibits differentiation of muscle progenitors (Miller et al. 2007).”
BackgroundProtein kinase A signalling via CREB controls myogenesis induced by Wnt proteins
Chen, A. E., Ginty, D. D., & Fan, C.-M. (2005) · Nature · doi:10.1038/nature03126 · Cited by 309
Cited by
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Murphy, M. M., Lawson, J. A., Mathew, S. J., Hutcheson, D. A., & Kardon, G. (2011) · Development · doi:10.1242/dev.064162 · Cited by 1,249
Self-citationZammit, P. S. (2017) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.11.011 · Cited by 887
Satellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140068 · Cited by 719
Gene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis
Buckingham, M., & Rigby, P. W. J. (2014) · Developmental Cell · doi:10.1016/j.devcel.2013.12.020 · Cited by 667
Metadata
- Authors
- Hutcheson, D. A., Zhao, J., Merrell, A., Haldar, M., & Kardon, G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-04-03
- Volume
- 23
- Issue
- 8
- Pages
- 997-1013
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2112468384
- Cited by
- 301
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Hutcheson, D. A., Zhao, J., Merrell, A., Haldar, M., & Kardon, G. (2009). Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for β-catenin. Genes & Development. https://doi.org/10.1101/gad.1769009
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