Cited by 929Muscle Physiology and DisordersCongenital heart defects researchDevelopmental Biology and Gene Regulation

Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis

Zammit, Peter S.·2017·Seminars in Cell & Developmental Biology

Abstract

Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development. These factors are also involved in specification of the muscle satellite cell lineage, which becomes the resident stem cell compartment inadult skeletal muscle. While MYF5, MYOD, Myogenin and MRF4 have subtle roles in mature muscle, they again play a crucial role in directing satellite cell function to regenerate skeletal muscle: linking the genetic control of developmental and regenerative myogenesis. Here, I review the role of the myogenic regulatory factors in developing and mature skeletal muscle, satellite cell specification and muscle regeneration.

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Crossref · 10.1016/j.semcdb.2017.11.011

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Authors
Zammit, P. S.
Affiliations
King's College London (GB)
Corresponding author
Zammit, Peter S.
Venue
Seminars in Cell & Developmental Biology
Publisher
Elsevier BV
Published
2017-12
Volume
72
Pages
19-32
ISSN
1084-9521 (ISSN-L)
OpenAlex
W2769580895
Cited by
887
References
151
Citations by year
2026: 114 · 2025: 108 · 2024: 156 · 2023: 112 · 2022: 117 · 2021: 108 · 2020: 95 · 2019: 48 · 2018: 28 · 2017: 1
FWCI
4.37
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medical Research Council (MR/P023215/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
myogenic regulatory factors, Myf5, MyoD, myogenin, MRF4, skeletal muscle development, satellite cells, muscle regeneration, myogenesis, muscle stem cells, transcription factors
MeSH terms
Animals, Regeneration, MyoD Protein, Myogenic Regulatory Factors, Myogenin, Muscle, Skeletal, Gene Expression Regulation, Developmental, Muscle Development, Satellite Cells, Skeletal Muscle, Myogenic Regulatory Factor 5

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