Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis
Abstract
Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development. These factors are also involved in specification of the muscle satellite cell lineage, which becomes the resident stem cell compartment inadult skeletal muscle. While MYF5, MYOD, Myogenin and MRF4 have subtle roles in mature muscle, they again play a crucial role in directing satellite cell function to regenerate skeletal muscle: linking the genetic control of developmental and regenerative myogenesis. Here, I review the role of the myogenic regulatory factors in developing and mature skeletal muscle, satellite cell specification and muscle regeneration.
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Up-regulation of Myf5 by ApN in skeletal muscle allows the activation of satellite cells and their commitment to regenerate the skeletal muscle.
“First, up-regulation of Myf5 by ApN in skeletal muscle [56] allows the activation of satellite cells and their commitment to regenerate the skeletal muscle [67].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [67]
ApN activates the expression of two key factors of muscle differentiation, Myogenin and Mrf4, which are essential for provoking cell fusion into multinucleated myotubes.
“Third, ApN can coordinate the last step of skeletal muscle regeneration. Indeed, it activates the expression of two key factors of muscle differentiation, Myogenin and Mrf4 [56], which are essential for provoking cell fusion into multinucleated myotubes [67] (Figure 3).”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [67]
Skeletal muscles of mdx-ApN mice displayed higher expression of two major factors of muscle proliferation (Myf5 and MyoD), and two major factors of muscle differentiation (Myogenin and Mrf4).
“Skeletal muscles of mdx-ApN mice displayed higher expression of two major factors of muscle proliferation (Myf5 and MyoD), and two major factors of muscle differentiation (Myogenin and Mrf4) [56,67].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [67]
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- Authors
- Zammit, P. S.
- Affiliations
- King's College London (GB)
- Corresponding author
- Zammit, Peter S.
- ORCID
- Zammit, Peter S.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 72
- Pages
- 19-32
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2769580895
- Cited by
- 887
- References
- 151
- Citations by year
- 2026: 114 · 2025: 108 · 2024: 156 · 2023: 112 · 2022: 117 · 2021: 108 · 2020: 95 · 2019: 48 · 2018: 28 · 2017: 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council (MR/P023215/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- myogenic regulatory factors, Myf5, MyoD, myogenin, MRF4, skeletal muscle development, satellite cells, muscle regeneration, myogenesis, muscle stem cells, transcription factors
- MeSH terms
- Animals, Regeneration, MyoD Protein, Myogenic Regulatory Factors, Myogenin, Muscle, Skeletal, Gene Expression Regulation, Developmental, Muscle Development, Satellite Cells, Skeletal Muscle, Myogenic Regulatory Factor 5
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