The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Integration of microRNA miR-122 in hepatic circadian gene expression
Open accessAbstract
In liver, most metabolic pathways are under circadian control, and hundreds of protein-encoding genes are thus transcribed in a cyclic fashion. Here we show that rhythmic transcription extends to the locus specifying miR-122, a highly abundant, hepatocyte-specific microRNA. Genetic loss-of-function and gain-of-function experiments have identified the orphan nuclear receptor REV-ERBα as the major circadian regulator of mir-122 transcription. Although due to its long half-life mature miR-122 accumulates at nearly constant rates throughout the day, this miRNA is tightly associated with control mechanisms governing circadian gene expression. Thus, the knockdown of miR-122 expression via an antisense oligonucleotide (ASO) strategy resulted in the up- and down-regulation of hundreds of mRNAs, of which a disproportionately high fraction accumulates in a circadian fashion. miR-122 has previously been linked to the regulation of cholesterol and lipid metabolism. The transcripts associated with these pathways indeed show the strongest time point-specific changes upon miR-122 depletion. The identification of Pparβ/δ and the peroxisome proliferator-activated receptor α (PPARα) coactivator Smarcd1/Baf60a as novel miR-122 targets suggests an involvement of the circadian metabolic regulators of the PPAR family in miR-122-mediated metabolic control.
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Cites
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Self-citationLNA-mediated microRNA silencing in non-human primates
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AMPK and PPARδ Agonists Are Exercise Mimetics
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Cited by
The widespread regulation of microRNA biogenesis, function and decay
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Self-citationBile acid signaling in metabolic disease and drug therapy
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The complex transcriptional landscape of the anucleate human platelet
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Metadata
- Authors
- Gatfield, D., Le Martelot, G., Vejnar, C. E., Gerlach, D., Schaad, O., Fleury-Olela, F., Ruskeepää, A.-L., Oresic, M., Esau, C. C., Zdobnov, E. M., & Schibler, U.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-06-01
- Volume
- 23
- Issue
- 11
- Pages
- 1313-1326
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2162423616
- Cited by
- 393
- References
- 10
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Gatfield, D., Le Martelot, G., Vejnar, C. E., Gerlach, D., Schaad, O., Fleury-Olela, F., Ruskeepää, A.-L., Oresic, M., Esau, C. C., Zdobnov, E. M., & Schibler, U. (2009). Integration of microRNA miR-122 in hepatic circadian gene expression. Genes & Development. https://doi.org/10.1101/gad.1781009
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