Coordination of circadian timing in mammals

Reppert, Steven M.; Weaver, David R.

doi:10.1038/nature00965

Cited by 4,379Circadian rhythm and melatoninSleep and Wakefulness ResearchAdvanced Frequency and Time Standards

Coordination of circadian timing in mammals

Reppert, Steven M., Weaver, David R.·2002·Nature

DOI 10.1038/nature00965

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Abstract

Time in the biological sense is measured by cycles that range from milliseconds to years. Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most ubiquitous and well-studied timing systems. At the core of this timing mechanism is an intricate molecular mechanism that ticks away in many different tissues throughout the body. However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.

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The central circadian clock in the SCN synchronizes peripheral clocks in liver, gut, pancreas, and adipose tissue via neural and hormonal pathways.
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From Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism (2018) · cites this paper as [1]
Circadian rhythms are near-24-hour oscillations found in essentially every physiological process in the human brain and body.
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From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [1]
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From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [1]
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Rhythmic Expression of BMAL1 mRNA Is Altered in Clock Mutant Mice: Differential Regulation in the Suprachiasmatic Nucleus and Peripheral Tissues
Oishi, K., Fukui, H., & Ishida, N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.2054 · Cited by 140 · see citing works
Circadian Regulation of Diverse Gene Products Revealed by mRNA Expression Profiling of Synchronized Fibroblasts
Grundschober, C., Delaunay, F., Pühlhofer, A., Triqueneaux, G., Laudet, V., Bartfai, T., & Nef, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107499200 · Cited by 127 · see citing works
Keeping time with the human genome
Clayton, J. D., Kyriacou, C. P., & Reppert, S. M. (2001) · Nature · doi:10.1038/35057006 · Cited by 122 · see citing works
Self-citation
Absence of Circadian Phase Resetting in Response to Bright Light Behind the Knees
Wright, K. P., & Czeisler, C. A. (2002) · Science · doi:10.1126/science.1071697 · Cited by 96 · see citing works
Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice
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Nuclear Export of Mammalian PERIOD Proteins
Vielhaber, E. L., Duricka, D., Ullman, K. S., & Virshup, D. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107726200 · Cited by 91 · see citing works
Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice
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Photic induction of Period gene expression is reduced in Clock mutant mice
Shearman, L. P., & Weaver, D. R. (1999) · Neuroreport · doi:10.1097/00001756-199902250-00031 · Cited by 56 · see citing works
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Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804 · see citing works
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
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PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
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Sleep state switching
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SIRT1 regulates circadian clock gene expression through PER2 deacetylation
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Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock
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Generation of circadian rhythms in the suprachiasmatic nucleus
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BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis
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Light as a central modulator of circadian rhythms, sleep and affect
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Mammalian circadian biology: elucidating genome-wide levels of temporal organization
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Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System
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Epigenetic mechanisms in memory formation
Levenson, J. M., & Sweatt, J. D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1604 · Cited by 767 · see citing works
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
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Circadian clocks and insulin resistance
Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733 · see citing works
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
The circadian clock: pacemaker and tumour suppressor
Fu, L., & Lee, C. C. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1072 · Cited by 678 · see citing works
System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock
Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658 · see citing works
Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism
Liu, C., Li, S., Liu, T., Borjigin, J., & Lin, J. D. (2007) · Nature · doi:10.1038/nature05767 · Cited by 643 · see citing works
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells
Gery, S., Komatsu, N., Baldjyan, L., Yu, A., Koo, D., & Koeffler, H. P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.038 · Cited by 630 · see citing works
Sleep disturbance as transdiagnostic: Consideration of neurobiological mechanisms
Harvey, A. G., Murray, G., Chandler, R. A., & Soehner, A. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.04.003 · Cited by 609 · see citing works
Circadian Rhythms: Mechanisms and Therapeutic Implications
Levi, F., & Schibler, U. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105208 · Cited by 645 · see citing works
The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601 · see citing works
High Caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women
Jakubowicz, D., Barnea, M., Wainstein, J., & Froy, O. (2013) · Obesity · doi:10.1002/oby.20460 · Cited by 593 · see citing works
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons
LeGates, T. A., Altimus, C. M., Wang, H., Lee, H.-K., Yang, S., Zhao, H., Kirkwood, A., Weber, E. T., & Hattar, S. (2012) · Nature · doi:10.1038/nature11673 · Cited by 577 · see citing works
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
Spanagel, R., Pendyala, G., Abarca, C., Zghoul, T., Sanchis-Segura, C., Magnone, M. C., Lascorz, J., Depner, M., Holzberg, D., Soyka, M., et al. (2005) · Nature Medicine · doi:10.1038/nm1163 · Cited by 594 · see citing works
Circadian orchestration of the hepatic proteome
Reddy, A. B., Karp, N. A., Maywood, E. S., Sage, E. A., Deery, M., O'Neill, J. S., Wong, G. K. Y., Chesham, J., Odell, M., Lilley, K. S., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.026 · Cited by 548 · see citing works
Strange vision: ganglion cells as circadian photoreceptors
Berson, D. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00130-9 · Cited by 546 · see citing works
Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis
Shimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502383102 · Cited by 536 · see citing works
Metabolism and Circadian Rhythms—Implications for Obesity
Froy, O. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0014 · Cited by 505 · see citing works
Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation
Haus, E. L., & Smolensky, M. H. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.08.003 · Cited by 499 · see citing works
PER2 controls lipid metabolism by direct regulation of PPARγ
Grimaldi, B., Bellet, M. M., Katada, S., Astarita, G., Hirayama, J., Amin, R. H., Granneman, J. G., Piomelli, D., Leff, T., & Sassone-Corsi, P. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.10.005 · Cited by 489 · see citing works
Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation
Eide, E. J., Woolf, M. F., Kang, H., Woolf, P., Hurst, W., Camacho, F., Vielhaber, E. L., Giovanni, A., & Virshup, D. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2795-2807.2005 · Cited by 495 · see citing works
The circadian clock and pathology of the ageing brain
Kondratova, A. A., & Kondratov, R. V. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3208 · Cited by 482 · see citing works
Linking neural activity and molecular oscillations in the SCN
Colwell, C. S. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3086 · Cited by 474 · see citing works
Obesity in mice with adipocyte-specific deletion of clock component Arntl
Paschos, G. K., Ibrahim, S., Song, W.-L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2979 · Cited by 465 · see citing works
Shift Work and Health: Current Problems and Preventive Actions
Costa, G. (2010) · Safety and Health at Work · doi:10.5491/shaw.2010.1.2.112 · Cited by 443 · see citing works
A clock shock: mouse CLOCK is not required for circadian oscillator function
DeBruyne, J. P., Noton, E., Lambert, C. M., Maywood, E. S., Weaver, D. R., & Reppert, S. M. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.041 · Cited by 430 · see citing works
Self-citation
Synchronization and Maintenance of Timekeeping in Suprachiasmatic Circadian Clock Cells by Neuropeptidergic Signaling
Maywood, E. S., Reddy, A. B., Wong, G. K. Y., O'Neill, J. S., O'Brien, J. A., McMahon, D. G., Harmar, A. J., Okamura, H., & Hastings, M. H. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.023 · Cited by 438 · see citing works
Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6
Doi, M., Takahashi, Y., Komatsu, R., Yamazaki, F., Yamada, H., Haraguchi, S., Emoto, N., Okuno, Y., Tsujimoto, G., Kanematsu, A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2061 · Cited by 431 · see citing works
Glucocorticoid regulation of the circadian clock modulates glucose homeostasis
So, A. Y.-L., Bernal, T. U., Pillsbury, M. L., Yamamoto, K. R., & Feldman, B. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909733106 · Cited by 431 · see citing works
Circadian clocks: regulators of endocrine and metabolic rhythms
Hastings, M., O’Neill, J. S., & Maywood, E. S. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0378 · Cited by 426 · see citing works
Later circadian timing of food intake is associated with increased body fat
McHill, A. W., Phillips, A. J., Czeisler, C. A., Keating, L., Yee, K., Barger, L. K., Garaulet, M., Scheer, F. A., & Klerman, E. B. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.161588 · Cited by 414 · see citing works
Considerations of circadian impact for defining ‘shift work’ in cancer studies: IARC Working Group Report
Stevens, R. G., Hansen, J., Costa, G., Haus, E., Kauppinen, T., Aronson, K. J., Castaño-Vinyals, G., Davis, S., Frings-Dresen, M. H. W., Fritschi, L., et al. (2011) · Occupational and Environmental Medicine · doi:10.1136/oem.2009.053512 · Cited by 421 · see citing works
The HPA â€“ Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain
Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419 · see citing works
cAMP-dependent signaling as a core component of the mammalian circadian pacemaker
O'Neill, J. S., Maywood, E. S., Chesham, J. E., Takahashi, J. S., & Hastings, M. H. (2008) · Science · doi:10.1126/science.1152506 · Cited by 418 · see citing works
Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease
Morton, A. J., Wood, N. I., Hastings, M. H., Hurelbrink, C., Barker, R. A., & Maywood, E. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3842-04.2005 · Cited by 403 · see citing works
The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration
Lightman, S. L., & Conway-Campbell, B. L. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2914 · Cited by 390 · see citing works
Timed high-fat diet resets circadian metabolism and prevents obesity
Sherman, H., Genzer, Y., Cohen, R., Chapnik, N., Madar, Z., & Froy, O. (2012) · The FASEB Journal · doi:10.1096/fj.12-208868 · Cited by 360 · see citing works
Sleep and circadian rhythms: key components in the regulation of energy metabolism
Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.06.079 · Cited by 351 · see citing works
Circadian rhythms govern cardiac repolarization and arrhythmogenesis
Jeyaraj, D., Haldar, S. M., Wan, X., McCauley, M. D., Ripperger, J. A., Hu, K., Lu, Y., Eapen, B. L., Sharma, N., Ficker, E., et al. (2012) · Nature · doi:10.1038/nature10852 · Cited by 343 · see citing works
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., & Schibler, U. (2010) · Cell · doi:10.1016/j.cell.2010.08.016 · Cited by 340 · see citing works
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
Eckle, T., Hartmann, K., Bonney, S., Reithel, S., Mittelbronn, M., Walker, L. A., Lowes, B. D., Han, J., Borchers, C. H., Buttrick, P. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2728 · Cited by 314 · see citing works
Coupling of Human Circadian and Cell Cycles by the Timeless Protein
Ünsal-Kaçmaz, K., Mullen, T. E., Kaufmann, W. K., & Sancar, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.3109-3116.2005 · Cited by 310 · see citing works
Transcriptional oscillation of canonical clock genes in mouse peripheral tissues
Yamamoto, T., Nakahata, Y., Soma, H., Akashi, M., Mamine, T., & Takumi, T. (2004) · BMC Molecular Biology · doi:10.1186/1471-2199-5-18 · Cited by 308 · see citing works
Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?
Jockers, R., Maurice, P., Boutin, J. A., & Delagrange, P. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.184 · Cited by 293 · see citing works
Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice
Lee, S., Donehower, L. A., Herron, A. J., Moore, D. D., & Fu, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010995 · Cited by 286 · see citing works
“The alternating activation and suppression of the BMAL1-driven positive loop and the PER/CRY-controlled negative loop result in a circadian oscillation of the molecular clock [16,17,18].”
Background
Neurophysiology of sleep and wakefulness: basic science and clinical implications
Schwartz, J., & Roth, T. (2008) · Current Neuropharmacology · doi:10.2174/157015908787386050 · Cited by 289 · see citing works
Scheduled exercise phase shifts the circadian clock in skeletal muscle
WOLFF, G., & ESSER, K. A. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318255cf4c · Cited by 291 · see citing works
Circadian Clocks and Metabolism
Marcheva, B., Ramsey, K. M., Peek, C. B., Affinati, A., Maury, E., & Bass, J. (2013) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-25950-0_6 · Cited by 282 · see citing works
Circadian rhythm and the gut microbiome
Voigt, R. M., Forsyth, C. B., Green, S. J., Engen, P. A., & Keshavarzian, A. (2016) · International Review of Neurobiology · doi:10.1016/bs.irn.2016.07.002 · Cited by 274 · see citing works
HPA Axis‐Rhythms
Spiga, F., Walker, J. J., Terry, J. R., & Lightman, S. L. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c140003 · Cited by 267 · see citing works
The role of mPer2 clock gene in glucocorticoid and feeding rhythms
Yang, S., Liu, A., Weidenhammer, A., Cooksey, R. C., McClain, D., Kim, M. K., Aguilera, G., Abel, E. D., & Chung, J. H. (2009) · Endocrinology · doi:10.1210/en.2008-0705 · Cited by 263 · see citing works
Time- and exercise-dependent gene regulation in human skeletal muscle
Zambon, A. C., McDearmon, E. L., Salomonis, N., Vranizan, K. M., Johansen, K. L., Adey, D., Takahashi, J. S., Schambelan, M., & Conklin, B. R. (2003) · Genome Biology · doi:10.1186/gb-2003-4-10-r61 · Cited by 254 · see citing works
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251 · see citing works
Circadian clocks: setting time by food
Mendoza, J. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01510.x · Cited by 257 · see citing works
Disruption of Circadian Rhythms Accelerates Development of Diabetes through Pancreatic Beta-Cell Loss and Dysfunction
Gale, J. E., Cox, H. I., Qian, J., Block, G. D., Colwell, C. S., & Matveyenko, A. V. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730411416341 · Cited by 247 · see citing works
Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei
Hastings, M. H., & Herzog, E. D. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730404268786 · Cited by 246 · see citing works
Circadian mechanisms of 24-hour blood pressure regulation and patterning
Smolensky, M. H., Hermida, R. C., & Portaluppi, F. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.02.003 · Cited by 237 · see citing works
Activation of 5′-AMP-activated Kinase with Diabetes Drug Metformin Induces Casein Kinase Iɛ (CKIɛ)-dependent Degradation of Clock Protein mPer2
Um, J. H., Yang, S., Yamazaki, S., Kang, H., Viollet, B., Foretz, M., & Chung, J. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700070200 · Cited by 244 · see citing works
Origin of ultradian pulsatility in the hypothalamic–pituitary–adrenal axis
Walker, J. J., Terry, J. R., & Lightman, S. L. (2010) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2009.2148 · Cited by 239 · see citing works
“The PVN also receives a major input from the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the body’s circadian rhythms (Reppert & Weaver 2002).”
Background
Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro
Yagita, K., Horie, K., Koinuma, S., Nakamura, W., Yamanaka, I., Urasaki, A., Shigeyoshi, Y., Kawakami, K., Shimada, S., Takeda, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913256107 · Cited by 241 · see citing works
Shift work and cancer – considerations on rationale, mechanisms, and epidemiology
Costa, G., Haus, E., & Stevens, R. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2899 · Cited by 241 · see citing works
The two CRYs of the butterfly
Zhu, H., Yuan, Q., Froy, O., Casselman, A., & Reppert, S. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.11.030 · Cited by 238 · see citing works
Self-citation
Sleep and circadian functioning: critical mechanisms in the mood disorders?
Harvey, A. G. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032210-104550 · Cited by 237 · see citing works
Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals
Kumar Jha, P., Challet, E., & Kalsbeek, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.024 · Cited by 235 · see citing works
SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket
Xing, W., Busino, L., Hinds, T. R., Marionni, S. T., Saifee, N. H., Bush, M. F., Pagano, M., & Zheng, N. (2013) · Nature · doi:10.1038/nature11964 · Cited by 234 · see citing works
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
Kang, T.-H., Lindsey-Boltz, L. A., Reardon, J. T., & Sancar, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915085107 · Cited by 250 · see citing works
Hippocampal-dependent learning requires a functional circadian system
Ruby, N. F., Hwang, C. E., Wessells, C., Fernandez, F., Zhang, P., Sapolsky, R., & Heller, H. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808259105 · Cited by 234 · see citing works
Effects of circadian disruption on the cardiometabolic system
Rüger, M., & Scheer, F. A. J. L. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9122-8 · Cited by 232 · see citing works
Circadian regulation of hippocampal long-term potentiation
Chaudhury, D., Wang, L. M., & Colwell, C. S. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405276352 · Cited by 231 · see citing works
Impact of nutrients on circadian rhythmicity
Oosterman, J. E., Kalsbeek, A., la Fleur, S. E., & Belsham, D. D. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00322.2014 · Cited by 221 · see citing works
Systematic review of sleep disturbances and circadian sleep desynchronization in autism spectrum disorder: toward an integrative model of a self-reinforcing loop
Carmassi, C., Palagini, L., Caruso, D., Masci, I., Nobili, L., Vita, A., & Dell’Osso, L. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00366 · Cited by 220 · see citing works
A clinical approach to circadian rhythm sleep disorders
Barion, A., & Zee, P. C. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.017 · Cited by 214 · see citing works
The impact of the circadian timing system on cardiovascular and metabolic function
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Authors: Reppert, S. M., & Weaver, D. R.
Affiliations: University of Massachusetts Chan Medical School (US)
Corresponding author: Reppert, Steven M.
ORCID: Reppert, Steven M.
Weaver, David R.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-08
Volume: 418
Issue: 6901
Pages: 935-941
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature00965
OpenAlex: W2003302378
Cited by: 4,379
References: 83
Citations by year: 2026: 139 · 2025: 152 · 2024: 162 · 2023: 193 · 2022: 198 · 2021: 182 · 2020: 197 · 2019: 162 · 2018: 172 · 2017: 210 · 2016: 196 · 2015: 204 · 2014: 216 · 2013: 212 · 2012: 218
FWCI: 14.96
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
eScholarship@UMassChan (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Advanced Frequency and Time Standards
Keywords: circadian rhythm, circadian clock, circadian pacemaker, suprachiasmatic nucleus, light input, molecular clock mechanisms, biological timing, mammals
MeSH terms: Animals, Circadian Rhythm, Gene Expression Regulation, Light, Mammals, Models, Biological, Phosphorylation, Suprachiasmatic Nucleus, Visual Pathways, Photoreceptor Cells, Vertebrate, Active Transport, Cell Nucleus, Feedback, Physiological

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