The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development
Open accessAbstract
Common lymphoid progenitors (CLPs) clonally produce both B- and T-cell lineages, but have little myeloid potential in vivo. However, some studies claim that the upstream lymphoid-primed multipotent progenitor (LMPP) is the thymic seeding population, and suggest that CLPs are primarily B-cell-restricted. To identify surface proteins that distinguish functional CLPs from B-cell progenitors, we used a new computational method of Mining Developmentally Regulated Genes (MiDReG). We identified Ly6d, which divides CLPs into two distinct populations: one that retains full in vivo lymphoid potential and produces more thymocytes at early timepoints than LMPP, and another that behaves essentially as a B-cell progenitor.
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Cites
Adult T-cell progenitors retain myeloid potential
Wada, H., Masuda, K., Satoh, R., Kakugawa, K., Ikawa, T., Katsura, Y., & Kawamoto, H. (2008) · Nature · doi:10.1038/nature06839 · Cited by 368
Cited by
FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data
Herman, J. S., Sagar, & Grün, D. (2018) · Nature Methods · doi:10.1038/nmeth.4662 · Cited by 363
Norddahl, G. L., Pronk, C. J., Wahlestedt, M., Sten, G., Nygren, J. M., Ugale, A., Sigvardsson, M., & Bryder, D. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.03.009 · Cited by 249
Nechanitzky, R., Akbas, D., Scherer, S., Györy, I., Hoyler, T., Ramamoorthy, S., Diefenbach, A., & Grosschedl, R. (2013) · Nature Immunology · doi:10.1038/ni.2641 · Cited by 218
Signal integration and crosstalk during thymocyte migration and emigration
Love, P. E., & Bhandoola, A. (2011) · Nature Reviews Immunology · doi:10.1038/nri2989 · Cited by 213
Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia
Somasundaram, R., Prasad, M. A. J., Ungerbäck, J., & Sigvardsson, M. (2015) · Blood · doi:10.1182/blood-2014-12-575688 · Cited by 135
Metadata
- Authors
- Inlay, M. A., Bhattacharya, D., Sahoo, D., Serwold, T., Seita, J., Karsunky, H., Plevritis, S. K., Dill, D. L., & Weissman, I. L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-10-15
- Volume
- 23
- Issue
- 20
- Pages
- 2376-2381
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2089500151
- Cited by
- 317
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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