The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells
Open accessAbstract
The homeobox gene Prox1 is crucial for mammalian lymphatic vascular development. In the absence of Prox1, lymphatic endothelial cells (LECs) are not specified. The maintenance of LEC identity also requires the constant expression of Prox1. However, the mechanisms controlling the expression of this gene in LECs remain poorly understood. The SRY-related gene Sox18 is required to induce Prox1 expression in venous LEC progenitors. Although Sox18 is also expressed in embryonic arteries, these vessels do not express Prox1, nor do they give rise to LECs. This finding suggests that some venous endothelial cell-specific factor is required for the activation of Prox1. Here we demonstrate that the nuclear hormone receptor Coup-TFII is necessary for the activation of Prox1 in embryonic veins by directly binding a conserved DNA domain in the regulatory region of Prox1. In addition, we show that the direct interaction between nuclear hormone receptors and Prox1 is also necessary for the maintenance of Prox1 expression during early stages of LEC specification and differentiation.
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Cites
Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T., & Honjo, T. (2002) · Nature Immunology · doi:10.1038/ni793 · Cited by 478
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The lymphatic vasculature in disease
Alitalo, K. (2011) · Nature Medicine · doi:10.1038/nm.2545 · Cited by 962
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Potente, M., & Mäkinen, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.36 · Cited by 653
Lymphatic Vessel Network Structure and Physiology
Breslin, J. W., Yang, Y., Scallan, J. P., Sweat, R. S., Adderley, S. P., & Murfee, W. L. (2018) · Comprehensive Physiology · doi:10.1002/cphy.c180015 · Cited by 341
Self-citationChoi, I., Chung, H. K., Ramu, S., Lee, H. N., Kim, K. E., Lee, S., Yoo, J., Choi, D., Lee, Y. S., Aguilar, B., et al. (2011) · Blood · doi:10.1182/blood-2010-07-298562 · Cited by 255
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor
Zheng, W., Tammela, T., Yamamoto, M., Anisimov, A., Holopainen, T., Kaijalainen, S., Karpanen, T., Lehti, K., Ylä-Herttuala, S., & Alitalo, K. (2011) · Blood · doi:10.1182/blood-2010-11-317800 · Cited by 132
Metadata
- Authors
- Srinivasan, R. S., Geng, X., Yang, Y., Wang, Y., Mukatira, S., Studer, M., Porto, M. P. R., Lagutin, O., & Oliver, G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-04-01
- Volume
- 24
- Issue
- 7
- Pages
- 696-707
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2129768496
- Cited by
- 284
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Srinivasan, R. S., Geng, X., Yang, Y., Wang, Y., Mukatira, S., Studer, M., Porto, M. P. R., Lagutin, O., & Oliver, G. (2010). The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes & Development. https://doi.org/10.1101/gad.1859310
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