Vascular heterogeneity and specialization in development and disease
Open accessAbstract
Blood and lymphatic vessels pervade almost all body tissues and have numerous essential roles in physiology and disease. The inner lining of these networks is formed by a single layer of endothelial cells, which is specialized according to the needs of the tissue that it supplies. Whereas the general mechanisms of blood and lymphatic vessel development are being defined with increasing molecular precision, studies of the processes of endothelial specialization remain mostly descriptive. Recent insights from genetic animal models illuminate how endothelial cells interact with each other and with their tissue environment, providing paradigms for vessel type- and organ-specific endothelial differentiation. Delineating these governing principles will be crucial for understanding how tissues develop and maintain, and how their function becomes abnormal in disease.
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The neurovasculature is highly heterogeneous, so much so that population-level landmark detection is infeasible.
“The neurovasculature in particular is highly heterogeneous, so much so that population-level landmark detection is infeasible [40].”
From Rapid patient-specific neural networks for intraoperative X-ray to volume registration (2025) · cites this paper as [40]
The Online summary and ‘Heterogeneity in vessel morphology’ section describe vascular heterogeneity, including differences within vessel networks, and Table 1 describes specialization of blood–brain-barrier vessels. The paper does not establish that neurovascular anatomy varies so much across people that population-level landmark detection is infeasible. Page numbers were unavailable in our copy. (LLM, conf=0.86)
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The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926 · see citing works
Structural and functional features of central nervous system lymphatic vessels
Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413 · see citing works
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142290 · Cited by 2,198 · see citing works
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
Kusumbe, A. P., Ramasamy, S. K., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13145 · Cited by 2,155 · see citing works
Mechanisms and regulation of endothelial VEGF receptor signalling
Simons, M., Gordon, E., & Claesson-Welsh, L. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.87 · Cited by 1,498 · see citing works
Végran, F., Boidot, R., Michiels, C., Sonveaux, P., & Feron, O. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2828 · Cited by 816 · see citing works
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
Winkler, E. A., Nishida, Y., Sagare, A. P., Rege, S. V., Bell, R. D., Perlmutter, D., Sengillo, J. D., Hillman, S., Kong, P., Nelson, A. R., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3966 · Cited by 689 · see citing works
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674 · see citing works
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Schoors, S., Bruning, U., Missiaen, R., Queiroz, K. C. S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A. R., Christen, S., Goveia, J., et al. (2015) · Nature · doi:10.1038/nature14362 · Cited by 646 · see citing works
Sabine, A., Agalarov, Y., Maby-El Hajjami, H., Jaquet, M., Hägerling, R., Pollmann, C., Bebber, D., Pfenniger, A., Miura, N., Dormond, O., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.020 · Cited by 411 · see citing works
Self-citationALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway
Larrivée, B., Prahst, C., Gordon, E., del Toro, R., Mathivet, T., Duarte, A., Simons, M., & Eichmann, A. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.02.005 · Cited by 359 · see citing works
Chronic DLL4 blockade induces vascular neoplasms
Yan, M., Callahan, C. A., Beyer, J. C., Allamneni, K. P., Zhang, G., Ridgway, J. B., Niessen, K., & Plowman, G. D. (2010) · Nature · doi:10.1038/nature08751 · Cited by 280 · see citing works
Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis
Fischer, A., Zalvide, J., Faurobert, E., Albiges-Rizo, C., & Tournier-Lasserve, E. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.02.004 · Cited by 199 · see citing works
Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions
Zheng, W., Nurmi, H., Appak, S., Sabine, A., Bovay, E., Korhonen, E. A., Orsenigo, F., Lohela, M., D’Amico, G., Holopainen, T., et al. (2014) · Genes & Development · doi:10.1101/gad.237677.114 · Cited by 134 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- 81 Wiley, D. M. et al. Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nature cell biology 13 , 686-692, (2011).
- 87 Potente, M. & Carmeliet, P. M. The Link Between Angiogenesis and Endothelial Metabolism. Annual Review of Physiology 79 , null, (2017).
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Shetty, S., Lalor, P. F., & Adams, D. H. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0020-y · Cited by 523 · see citing works
Engineering the multiscale complexity of vascular networks
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Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
Sabbagh, M. F., Heng, J. S., Luo, C., Castanon, R. G., Nery, J. R., Rattner, A., Goff, L. A., Ecker, J. R., & Nathans, J. (2018) · eLife · doi:10.7554/elife.36187 · Cited by 245 · see citing works
The endothelium–bone axis in development, homeostasis and bone and joint disease
Tuckermann, J., & Adams, R. H. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00682-3 · Cited by 258 · see citing works
The perivascular origin of pathological fibroblasts
Di Carlo, S. E., & Peduto, L. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93558 · Cited by 164 · see citing works
Vion, A.-C., Perovic, T., Petit, C., Hollfinger, I., Bartels-Klein, E., Frampton, E., Gordon, E., Claesson-Welsh, L., & Gerhardt, H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.623769 · Cited by 103 · see citing works
Wang, X., Sun, Q., & Pei, J. (2018) · Micromachines · doi:10.3390/mi9100493 · Cited by 106 · see citing works
Endothelial sensing of AHR ligands regulates intestinal homeostasis
Wiggins, B. G., Wang, Y.-F., Burke, A., Grunberg, N., Vlachaki Walker, J. M., Dore, M., Chahrour, C., Pennycook, B. R., Sanchez-Garrido, J., Vernia, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06508-4 · Cited by 89 · see citing works
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Gao, Y., & Galis, Z. S. (2021) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.120.314346 · Cited by 62 · see citing works
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Adler, M., Chavan, A. R., & Medzhitov, R. (2023) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120420-113830 · Cited by 40 · see citing works
Nath, K. A., O’Brien, D. R., Croatt, A. J., Grande, J. P., Ackerman, A. W., Nath, M. C., Yamada, S., Terzic, A., Tchkonia, T., Kirkland, J. L., et al. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00308.2018 · Cited by 40 · see citing works
Squidiff: predicting cellular development and responses to perturbations using a diffusion model
He, S., Zhu, Y., Tavakol, D. N., Ye, H., Lao, Y.-H., Zhu, Z., Xu, C., Chauhan, S., Garty, G., Tomer, R., et al. (2026) · Nature Methods · doi:10.1038/s41592-025-02877-y · Cited by 38 · see citing works
Rapid patient-specific neural networks for intraoperative X-ray to volume registration
Gopalakrishnan, V., Chlorogiannis, D.-D., Abumoussa, A., Larson, A. M., Haouchine, N., Orbach, D. B., Frisken, S., Dey, N., & Golland, P. (2025) · arXiv · doi:10.48550/arxiv.2503.16309 · Cited by 2 · see citing works
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Sipilä, T., Ponna, S. K., Venkatesha Murthy, A., Pink, A., Enkavi, G., Bohra, S. K., Lewna, K., Ganesh, K., Liu, Q., Korhonen, M., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci190552
Self-citation
- Authors
- Potente, M., & Mäkinen, T.
- Affiliations
- Max Planck Institute for Heart and Lung Research (DE)
- Uppsala University (SE)
- Corresponding author
- Potente, Michael
- Mäkinen, Taija
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2017-05-24
- Volume
- 18
- Issue
- 8
- Pages
- 477-494
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2618307797
- Cited by
- 653
- References
- 14
- Citations by year
- 2026: 75 · 2025: 94 · 2024: 83 · 2023: 73 · 2022: 75 · 2021: 71 · 2020: 64 · 2019: 53 · 2018: 53 · 2017: 10 · 2015: 1 · 2012: 1
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- green
- urn.kb.se
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- vascular heterogeneity, endothelial differentiation, blood vessels, lymphatic vessels, endothelial cell interaction, vascular disease, histogenesis
- MeSH terms
- Animals, Blood Vessels, Cell Differentiation, Humans, Lymphatic Vessels, Endothelial Cells
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