The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse
Open accessAbstract
Although the blood vessel-specific fluorescent transgenic mouse has been an excellent tool to study vasculogenesis and angiogenesis, a lymphatic-specific fluorescent mouse model has not been established to date. Here we report a transgenic animal model that expresses the green fluorescent protein under the promoter of Prox1, a master control gene in lymphatic development. Generated using an approximately 200-kb-long bacterial artificial chromosome harboring the entire Prox1 gene, this Prox1-green fluorescent protein mouse was found to faithfully recapitulate the expression pattern of the Prox1 gene in lymphatic endothelial cells and other Prox1-expressing organs, and enabled us to conveniently visualize detailed structure and morphology of lymphatic vessels and networks throughout development. Our data demonstrate that this novel transgenic mouse can be extremely useful for detection, imaging, and isolation of lymphatic vessels and monitoring wound-associated lymphangiogenesis. Together, this Prox1-green fluorescent protein transgenic mouse will be a great tool for the lymphatic research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Prox1 Function Is Required for the Development of the Murine Lymphatic System
Wigle, J. T., & Oliver, G. (1999) · Cell · doi:10.1016/s0092-8674(00)81511-1 · Cited by 1,579
Functionally specialized junctions between endothelial cells of lymphatic vessels
Baluk, P., Fuxe, J., Hashizume, H., Romano, T., Lashnits, E., Butz, S., Vestweber, D., Corada, M., Molendini, C., Dejana, E., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062596 · Cited by 1,006
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Wigle, J. T., Harvey, N., Detmar, M., Lagutina, I., Grosveld, G., Gunn, M. D., Jackson, D. G., & Oliver, G. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1505 · Cited by 943
Sox18 induces development of the lymphatic vasculature in mice
François, M., Caprini, A., Hosking, B., Orsenigo, F., Wilhelm, D., Browne, C., Paavonen, K., Karnezis, T., Shayan, R., Downes, M., et al. (2008) · Nature · doi:10.1038/nature07391 · Cited by 555
Schlaeger, T. M., Bartunkova, S., Lawitts, J. A., Teichmann, G., Risau, W., Deutsch, U., & Sato, T. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3058 · Cited by 473
Universal GFP reporter for the study of vascular development
Motoike, T., Loughna, S., Perens, E., Roman, B. L., Liao, W., Chau, T. C., Richardson, C. D., Kawate, T., Kuno, J., Weinstein, B. M., et al. (2000) · genesis · doi:10.1002/1526-968x(200010)28:2<75::aid-gene50>3.0.co;2-s · Cited by 451
Prox1 function is crucial for mouse lens-fibre elongation
Wigle, J. T., Chowdhury, K., Gruss, P., & Oliver, G. (1999) · Nature Genetics · doi:10.1038/6844 · Cited by 432
Dyer, M. A., Livesey, F. J., Cepko, C. L., & Oliver, G. (2003) · Nature Genetics · doi:10.1038/ng1144 · Cited by 405
Hepatocyte migration during liver development requires Prox1
Sosa-Pineda, B., Wigle, J. T., & Oliver, G. (2000) · Nature Genetics · doi:10.1038/76996 · Cited by 381
Cited by
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142290 · Cited by 2,198
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
Ahn, J. H., Cho, H., Kim, J.-H., Kim, S. H., Ham, J.-S., Park, I., Suh, S. H., Hong, S. P., Song, J.-H., Hong, Y.-K., et al. (2019) · Nature · doi:10.1038/s41586-019-1419-5 · Cited by 811
Self-citationMa, Q., Ineichen, B. V., Detmar, M., & Proulx, S. T. (2017) · Nature Communications · doi:10.1038/s41467-017-01484-6 · Cited by 690
Cai, R., Pan, C., Ghasemigharagoz, A., Todorov, M. I., Förstera, B., Zhao, S., Bhatia, H. S., Parra-Damas, A., Mrowka, L., Theodorou, D., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0301-3 · Cited by 470
Development and plasticity of meningeal lymphatic vessels
Antila, S., Karaman, S., Nurmi, H., Airavaara, M., Voutilainen, M. H., Mathivet, T., Chilov, D., Li, Z., Koppinen, T., Park, J.-H., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20170391 · Cited by 466
Metadata
- Authors
- Choi, I., Chung, H. K., Ramu, S., Lee, H. N., Kim, K. E., Lee, S., Yoo, J., Choi, D., Lee, Y. S., Aguilar, B., & Hong, Y.-K.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-01-06
- Volume
- 117
- Issue
- 1
- Pages
- 362-365
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2059164493
- Cited by
- 255
- References
- 23
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse. https://app.cochat.ai/papers/10.1182/blood-2010-07-298562
- The paper
- Choi, I., Chung, H. K., Ramu, S., Lee, H. N., Kim, K. E., Lee, S., Yoo, J., Choi, D., Lee, Y. S., Aguilar, B., & Hong, Y.-K. (2011). Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse. Blood. https://doi.org/10.1182/blood-2010-07-298562
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
