The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Age-associated inflammation inhibits epidermal stem cell function
Abstract
Altered stem cell homeostasis is linked to organismal aging. However, the mechanisms involved remain poorly understood. Here we report novel alterations in hair follicle stem cells during skin aging, including increased numbers, decreased function, and an inability to tolerate stress. Performing high-throughput RNA sequencing on aging stem cells, cytokine arrays, and functional assays, we identify an age-associated imbalance in epidermal Jak–Stat signaling that inhibits stem cell function. Collectively, this study reveals a role for the aging epidermis in the disruption of cytokine and stem cell homeostasis, suggesting that stem cell decline during aging may be part of broader tumor-suppressive mechanisms.
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“age-associated inflammation inhibits epidermal stem cell function”
From The Hallmarks of Aging (2013) · cites this paper as Doles et al., 2012
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Cites
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
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Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564
Cell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · cited 3×
“As some stem cell compartments undergo dramatic ageassociated changes (including alterations in cell number, decreased regenerative capacity, and fate change), a decline in stem cell function is suggested to contribute to the aging process (Conboy et al. 2003; Rossi et al. 2005; Molofsky et al. 2006).”
BackgroundNotch-Mediated Restoration of Regenerative Potential to Aged Muscle
Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972 · cited 2×
“As some stem cell compartments undergo dramatic ageassociated changes (including alterations in cell number, decreased regenerative capacity, and fate change), a decline in stem cell function is suggested to contribute to the aging process (Conboy et al. 2003; Rossi et al. 2005; Molofsky et al. 2006).”
BackgroundDecline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis
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“…of tumor initiation and that this Krt-15 stem cell population was recently identified as a target cell of origin in squamous cell carcinoma (Keyes et al. 2011; Lapouge et al. 2011; White et al. 2011), the expansion of this population during aging could significantly increase the chance of…”
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Research works printed but not linked: 25
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Senescence and aging: Causes, consequences, and therapeutic avenues
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Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., & Nishimura, E. K. (2016) · Science · doi:10.1126/science.aad4395 · Cited by 416
STAT3 signaling controls satellite cell expansion and skeletal muscle repair
Tierney, M. T., Aydogdu, T., Sala, D., Malecova, B., Gatto, S., Puri, P. L., Latella, L., & Sacco, A. (2014) · Nature Medicine · doi:10.1038/nm.3656 · Cited by 401
The aging skin microenvironment dictates stem cell behavior
Ge, Y., Miao, Y., Gur-Cohen, S., Gomez, N., Yang, H., Nikolova, M., Polak, L., Hu, Y., Verma, A., Elemento, O., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901720117 · Cited by 190
Metadata
- Authors
- Doles, J., Storer, M., Cozzuto, L., Roma, G., & Keyes, W. M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-09-12
- Volume
- 26
- Issue
- 19
- Pages
- 2144-2153
- ISSN
- 0890-9369
- 1549-5477
- Cited by
- 160
- References
- 8
- Language
- en
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