The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Functional microdomains in bacterial membranes
Open accessAbstract
The membranes of eukaryotic cells harbor microdomains known as lipid rafts that contain a variety of signaling and transport proteins. Here we show that bacterial membranes contain microdomains functionally similar to those of eukaryotic cells. These membrane microdomains from diverse bacteria harbor homologs of Flotillin-1, a eukaryotic protein found exclusively in lipid rafts, along with proteins involved in signaling and transport. Inhibition of lipid raft formation through the action of zaragozic acid—a known inhibitor of squalene synthases—impaired biofilm formation and protein secretion but not cell viability. The orchestration of physiological processes in microdomains may be a more widespread feature of membranes than previously appreciated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lipid rafts as a membrane-organizing principle
Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417
Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains
Ritter, M., Schmidt, S., Jakab, M., Paulmichl, M., & Henderson, R. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350122 · Cited by 3,923
SMART, a simple modular architecture research tool: Identification of signaling domains
Schultz, J., Milpetz, F., Bork, P., & Ponting, C. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.5857 · Cited by 3,599
O'Toole, G. A., & Kolter, R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00797.x · Cited by 2,537
Self-citationRafts defined: a report on the Keystone symposium on lipid rafts and cell function
Pike, L. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.e600002-jlr200 · Cited by 1,500
Molecular biological methods for Bacillus
Harwood, C. R., & Cutting, S. M. (1990) · Cited by 1,430
Essential Bacillus subtilis genes
Kobayashi, K., Ehrlich, S. D., Albertini, A., Amati, G., Andersen, K. K., Arnaud, M., Asai, K., Ashikaga, S., Aymerich, S., Bessieres, P., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730515100 · Cited by 1,328
Fruiting body formation by Bacillus subtilis
Branda, S. S., González-Pastor, J. E., Ben-Yehuda, S., Losick, R., & Kolter, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191384198 · Cited by 1,129
Self-citationSMART 6: recent updates and new developments
Letunic, I., Doerks, T., & Bork, P. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn808 · Cited by 956
Arnaud, M., Chastanet, A., & Débarbouillé, M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6887-6891.2004 · Cited by 944
Cited by
Fleitas Martínez, O., Cardoso, M. H., Ribeiro, S. M., & Franco, O. L. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00074 · Cited by 304
Functional convergence of hopanoids and sterols in membrane ordering
Sáenz, J. P., Sezgin, E., Schwille, P., & Simons, K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212141109 · Cited by 181
Rexroth, S., Mullineaux, C. W., Ellinger, D., Sendtko, E., Rögner, M., & Koenig, F. (2011) · The Plant Cell · doi:10.1105/tpc.111.085779 · Cited by 136
Cardiolipin binding in bacterial respiratory complexes: Structural and functional implications
Arias-Cartin, R., Grimaldi, S., Arnoux, P., Guigliarelli, B., & Magalon, A. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.04.005 · Cited by 117
WELANDER, P. V., DOUGHTY, D. M., WU, C. ‐., MEHAY, S., SUMMONS, R. E., & NEWMAN, D. K. (2012) · Geobiology · doi:10.1111/j.1472-4669.2011.00314.x · Cited by 101
Metadata
- Authors
- López, D., & Kolter, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-08-16
- Volume
- 24
- Issue
- 17
- Pages
- 1893-1902
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2121462614
- Cited by
- 346
- References
- 54
- Type
- posted content
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Functional microdomains in bacterial membranes. https://app.cochat.ai/papers/10.1101/gad.1945010
- The paper
- López, D., & Kolter, R. (2010). Functional microdomains in bacterial membranes. Genes & Development. https://doi.org/10.1101/gad.1945010
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
