The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Interactions between Hedgehog proteins and their binding partners come into view
Open accessAbstract
Hedgehog (Hh) proteins are secreted signaling molecules that mediate essential tissue-patterning events during embryonic development and function in tissue homeostasis and regeneration throughout life. Hh signaling is regulated by multiple mechanisms, including covalent lipid modification of the Hh protein and interactions with multiple protein and glycan partners. Unraveling the nature and effects of these interactions has proven challenging, but recent structural and biophysical studies of Hh proteins and active fragments of heparin, Ihog, Cdo, Boc, Hedgehog-interacting protein (Hhip), Patched (Ptc), and the monoclonal antibody 5E1 have added a new level of molecular detail to our understanding of how Hh signal response and distribution are regulated within tissues. We review these results and discuss their implications for understanding Hh signaling in normal and disease states.
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Citations
Cites
Vertebrate Smoothened functions at the primary cilium
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
Rohatgi, R., Milenkovic, L., & Scott, M. P. (2007) · Science · doi:10.1126/science.1139740 · Cited by 1,426
Patched acts catalytically to suppress the activity of Smoothened
Taipale, J., Cooper, M. K., Maiti, T., & Beachy, P. A. (2002) · Nature · doi:10.1038/nature00989 · Cited by 794 · cited 2×
“Ptc normally inhibits the activity of Smo, a positive regulator of Hedgehog pathway activation (Denef et al. 2000; Taipale et al. 2002).”
BackgroundSelf-citationLee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581
Self-citation
Cited by
The mechanisms of Hedgehog signalling and its roles in development and disease
Briscoe, J., & Thérond, P. P. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3598 · Cited by 1,751
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
Takebe, N., Miele, L., Harris, P. J., Jeong, W., Bando, H., Kahn, M., Yang, S. X., & Ivy, S. P. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.61 · Cited by 1,298
Mechanisms and functions of Hedgehog signalling across the metazoa
Ingham, P. W., Nakano, Y., & Seger, C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2984 · Cited by 605
The Hedgehog Signal Transduction Network
Robbins, D. J., Fei, D. L., & Riobo, N. A. (2012) · Science Signaling · doi:10.1126/scisignal.2002906 · Cited by 419
Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration
Hsu, Y.-C., Li, L., & Fuchs, E. (2014) · Cell · doi:10.1016/j.cell.2014.02.057 · Cited by 379
Metadata
- Authors
- Beachy, P. A., Hymowitz, S. G., Lazarus, R. A., Leahy, D. J., & Siebold, C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-09-15
- Volume
- 24
- Issue
- 18
- Pages
- 2001-2012
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2124079918
- Cited by
- 212
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Beachy, P. A., Hymowitz, S. G., Lazarus, R. A., Leahy, D. J., & Siebold, C. (2010). Interactions between Hedgehog proteins and their binding partners come into view. Genes & Development. https://doi.org/10.1101/gad.1951710
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