The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration
Open accessAbstract
SUMMARY Transit-amplifying cells (TACs) are an early intermediate in tissue regeneration. Here, using hair follicles (HFs) as paradigm, we show that emerging TACs constitute a signaling center that orchestrates tissue growth. While primed stem cells (SCs) generate TACs, quiescent-SCs only proliferate after TACs form and begin expressing Sonic Hedgehog (SHH). TAC generation is independent of autocrine SHH, but their pool wanes if they can’t produce it. We trace this paradox to two direct actions of SHH: promoting quiescent-SC proliferation and regulating dermal factors that stoke TAC expansion. Ingrained within quiescent-SC’s special sensitivity to SHH signaling is their high expression of GAS1. Without sufficient input from quiescent-SCs, replenishment of primed-SCs for the next hair cycle is compromised, delaying regeneration and eventually leading to regeneration failure. Our findings unveil TACs as transient but indispensable integrator of SC niche components and reveal an intriguing interdependency of primed and quiescent SC populations on tissue regeneration.
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Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
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Identification of the haematopoietic stem cell niche and control of the niche size
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Self-citationPaneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
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Defining the Epithelial Stem Cell Niche in Skin
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Self-citationStem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life
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Self-citationPioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice
Adam, R. C., Yang, H., Rockowitz, S., Larsen, S. B., Nikolova, M., Oristian, D. S., Polak, L., Kadaja, M., Asare, A., Zheng, D., et al. (2015) · Nature · doi:10.1038/nature14289 · Cited by 375
Self-citationTissue Stem Cells: Architects of Their Niches
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Metadata
- Authors
- Hsu, Y.-C., Li, L., & Fuchs, E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 157
- Issue
- 4
- Pages
- 935-949
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2048135890
- Cited by
- 379
- References
- 68
- FWCI
- 40.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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