D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

The biology of VEGF and its receptors

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IDH1 and IDH2 Mutations in Gliomas

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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Rapid intraoperative molecular genetic classification of gliomas using Raman spectroscopy

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A Potent Blood–Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model

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From genomics to the clinic: biological and translational insights of mutant IDH1/2 in glioma

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Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia

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Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma

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Collagen Prolyl Hydroxylases Are Bifunctional Growth Regulators in Melanoma

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Mutant IDH in Gliomas: Role in Cancer and Treatment Options

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D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth

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2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas

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The clinical use of IDH1 and IDH2 mutations in gliomas

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Antagonistic functional duality of cancer genes

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Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinoma

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Glutamate as chemotactic fuel for diffuse glioma cells: Are they glutamate suckers?

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Molecular oncogenesis of chondrosarcoma: impact for targeted treatment

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Navigating redox imbalance: the role of oxidative stress in embryonic development and long-term health outcomes

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Roles of IDH1/2 and TET2 mutations in myeloid disorders

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Epigenetic regulators and their impact on therapy in acute myeloid leukemia

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Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and Elicits Synthetic Lethality in Glioblastoma

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Glial Progenitors as Targets for Transformation in Glioma

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Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies

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Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

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High IDH1 expression is associated with a poor prognosis in cytogenetically normal acute myeloid leukemia

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Modeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system

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Genetically Engineered Mouse Models of Gliomas: Technological Developments for Translational Discoveries

Noorani, I. (2019) · Cancers · doi:10.3390/cancers11091335 · Cited by 45

Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions

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Interrogating the Druggability of the 2-Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics

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Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change

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IDH mutations in liver cell plasticity and biliary cancer

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Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression

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Impact of CDKN2A/B Homozygous Deletion on the Prognosis and Biology of IDH-Mutant Glioma

Huang, L. E. (2022) · Biomedicines · doi:10.3390/biomedicines10020246 · Cited by 43

IDH Mutations in Glioma: Molecular, Cellular, Diagnostic, and Clinical Implications

Choate, K. A., Pratt, E. P. S., Jennings, M. J., Winn, R. J., & Mann, P. B. (2024) · Biology · doi:10.3390/biology13110885 · Cited by 49

Expanding the view of breast cancer metabolism: Promising molecular targets and therapeutic opportunities

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Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron

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SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas

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Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity

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L2hgdh Deficiency Accumulates l -2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration

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Molecular Targets in Glioblastoma

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IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced

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IDH1, lipid metabolism and cancer: Shedding new light on old ideas

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Biological Significance of Mutant Isocitrate Dehydrogenase 1 and 2 in Gliomagenesis

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The Updated World Health Organization Glioma Classification: Cellular and Molecular Origins of Adult Infiltrating Gliomas

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Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells

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IGFBP2 expression predicts IDH-mutant glioma patient survival

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Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP

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Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

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Determining venous thromboembolism risk in patients with adult-type diffuse glioma

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Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective

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Warburg and Krebs and related effects in cancer

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Recent advances in the biology of tumour hypoxia with relevance to diagnostic practice and tissue‐based research

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IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation

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Epigenetic Reprogramming for Targeting IDH-Mutant Malignant Gliomas

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IDH1 Targeting as a New Potential Option for Intrahepatic Cholangiocarcinoma Treatment—Current State and Future Perspectives

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Contemporary murine models in preclinical astrocytoma drug development

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Enigmas of IDH mutations in hematology/oncology

Heuser, M., Cruz, M. M. A., Goparaju, R., & Chaturvedi, A. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.05.005 · Cited by 28

IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53

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Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila

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Dynamic links between mechanical forces and metabolism shape the tumor milieu

Bertolio, R., Napoletano, F., & Sal, G. D. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102218 · Cited by 28

Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia

Sirenko, M., Lee, S., Sun, Z., Chaligne, R., Loghavi, S., Asimomitis, G., Brierley, C. K., Bernard, E., Cai, S. F., Myers, R. M., et al. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.04.012 · Cited by 28

Genetic factors affecting intraoperative 5-aminolevulinic acid-induced fluorescence of diffuse gliomas

Saito, K., Hirai, T., Takeshima, H., Kadota, Y., Yamashita, S., Ivanova, A., & Yokogami, K. (2017) · Radiology and Oncology · doi:10.1515/raon-2017-0019 · Cited by 27

Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish

Shi, X. E., He, A. B.-L., Ma, A. C. H., Guo, Y., Chi, Y., Man, C. H., Zhang, W., Zhang, Y., Wen, Z., Cheng, T., et al. (2015) · Blood · doi:10.1182/blood-2014-09-601187 · Cited by 27

ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells

Wang, L., Mao, B., Fan, K., Sun, R., Zhang, J., Liang, H., & Liu, Y. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00370-8 · Cited by 25

Genome-wide transcriptional analyses of Chinese patients reveal cell migration is attenuated in IDH1-mutant glioblastomas

Hu, H., Wang, Z., Liu, Y., Zhang, C., Li, M., Zhang, W., Wang, K., Cai, J., Cheng, W., Huang, H., et al. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.12.018 · Cited by 26

Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the Mechanisms

Keßler, J., Hohmann, T., Güttler, A., Petrenko, M., Ostheimer, C., Hohmann, U., Bache, M., Dehghani, F., & Vordermark, D. (2019) · Cancers · doi:10.3390/cancers11060889 · Cited by 28

Oncometabolite 2-hydroxyglutarate regulates anti-tumor immunity

Cai, M., Zhao, J., Ding, Q., & Wei, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24454 · Cited by 30

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

Gruber, E., So, J., Lewis, A. C., Franich, R. L., Cole, R., Martelotto, L. G., Rogers, A. J., Vidacs, E., Fraser, P., Stanley, K. L., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111182 · Cited by 28

IDH mutations associated impact on related cancer epidemiology and subsequent effect toward HIF-1α

Semukunzi, H., Roy, D., Li, H., Khan, G. J., Lyu, X., Yuan, S., & Lin, S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.083 · Cited by 25

Extracellular glutamate and IDH1R132H inhibitor promote glioma growth by boosting redox potential

Tiburcio, P. D. B., Gillespie, D. L., Jensen, R. L., & Huang, E. L. (2020) · Journal of Neuro-Oncology · doi:10.1007/s11060-019-03359-w · Cited by 25

Current biomarker-associated procedures of cancer modeling-a reference in the context of IDH1 mutant glioma

Mehrjardi, N. Z., Hänggi, D., & Kahlert, U. D. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03196-0 · Cited by 23

ALKR1275Q perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN

Ueda, T., Nakata, Y., Yamasaki, N., Oda, H., Sentani, K., Kanai, A., Onishi, N., Ikeda, K., Sera, Y., Honda, Z.-I., et al. (2016) · Oncogene · doi:10.1038/onc.2015.519 · Cited by 23

Isocitrate dehydrogenase mutations in chondrosarcoma

Azzi, G., Velez, M., & Mathias-Machado, M. C. (2014) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000092 · Cited by 23

Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM1

Ma, D., Zhan, D., Fu, Y., Wei, S., Lal, B., Wang, J., Li, Y.-Q., López-Bertoni, H., Yalçın, F., Dzaye, O. D. A., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.038 · Cited by 23

PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia

Wang, T., Zhou, Y., Fan, Y., Duan, H., Guo, X., Chang, J., Jiang, Y., Li, C., Zhang, F., Gao, Y., et al. (2023) · Advanced Science · doi:10.1002/advs.202205949 · Cited by 23

Genetically Modeled Mice with Mutations in Mitochondrial Metabolic Enzymes for the Study of Cancer

Piruat, J. I., & Millán‐Uclés, Á. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00200 · Cited by 21

Expanding the Reach of Cancer Metabolomics

Metallo, C. M. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0433 · Cited by 23

Molecular Genetics of Secondary Glioblastoma

Mansouri, A., Karamchandani, J., & Das, S. (2017) · Codon Publications eBooks · doi:10.15586/codon.glioblastoma.2017.ch2 · Cited by 23

Nuclear FABP7 regulates cell proliferation of wild‐type IDH1 glioma through caveolae formation

Kagawa, Y., Umaru, B. A., Kanamori, M., Zama, R., Shil, S. K., Miyazaki, H., Kobayashi, S., Wannakul, T., Yang, S., Tominaga, T., et al. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13130 · Cited by 23

LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL

Ko, A., Hasanain, M., Oh, Y. T., D’Angelo, F., Sommer, D., Frangaj, B., Tran, S., Bielle, F., Pollo, B., Paterra, R., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0376 · Cited by 24

HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma

Garrett, M. C., Albano, R., Carnwath, T., Elahi, L. S., Behrmann, C. A., Pemberton, M., Woo, D., O'Brien, E. J., VanCauwenbergh, B., Perentesis, J. P., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-33889-3 · Cited by 27

IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation

Park, J. W., Kwak, J., Kim, K. W., Jung, S., Nam, C. H., Kim, H. J., Lee, S. M., Choi, C., Ahn, Y., Park, J., et al. (2026) · Science · doi:10.1126/science.adt0559 · Cited by 23

IDH1/2 Mutations in Cancer Stem Cells and Their Implications for Differentiation Therapy

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