The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Dwarf mice produced by genetic ablation of growth hormone-expressing cells.
Open accessAbstract
Fusion of the 310 bp located 5' of the rat growth hormone (GH) gene to the human GH structural gene resulted in somatotrope-specific expression in transgenic mice. Human GH transcripts were detected only in pituitaries of these mice, and immunocytochemical analyses revealed that this expression was limited to GH-expressing cell types. The rat GH 5' sequences were then used to direct the expression of diphtheria toxin to the GH-expressing cells of transgenic mice. A line of mice was established which lacks detectable levels of circulating GH. This deficiency resulted in dwarfism; transgenic animals grew only to half the size of nontransgenic littermates. Nearly all somatotropes were absent, as shown by GH immunostaining in the transgenic pituitaries. Prolactin (PRL)-producing lactotropes, thought to share a common cellular origin with somatotropes, were also reduced in numbers. A model for the lineal relationships between GH- and PRL-synthesizing cells is proposed.
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Cites
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C., & Evans, R. M. (1982) · Nature · doi:10.1038/300611a0 · Cited by 1,340
Self-citationD'Ercole, A. J., Stiles, A. D., & Underwood, L. E. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.3.935 · Cited by 1,186
Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.
Brinster, R. L., Chen, H. Y., Trumbauer, M. E., Yagle, M. K., & Palmiter, R. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4438 · Cited by 1,027
Self-citationIntrons increase transcriptional efficiency in transgenic mice.
Brinster, R. L., Allen, J. M., Behringer, R. R., Gelinas, R. E., & Palmiter, R. D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.3.836 · Cited by 722
Self-citationMetallothionein-Human GH Fusion Genes Stimulate Growth of Mice
Palmiter, R. D., Norstedt, G., Gelinas, R. E., Hammer, R. E., & Brinster, R. L. (1983) · Science · doi:10.1126/science.6356363 · Cited by 676
Self-citationRegulation of insulin-like growth factor I gene expression by growth hormone.
Mathews, L. S., Norstedt, G., & Palmiter, R. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9343 · Cited by 553
Self-citationAge- and Sex-Related Differences in Episodic Growth Hormone Secretion in the Rat*
EDÉN, S. (1979) · Endocrinology · doi:10.1210/endo-105-2-555 · Cited by 536
Fate map for the 32-cell stage of Xenopus laevis
Dale, L., & Slack, J. M. W. (1987) · Development · doi:10.1242/dev.99.4.527 · Cited by 507
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene
Palmiter, R. D., Behringer, R. R., Quaife, C. J., Maxwell, F., Maxwell, I. H., & Brinster, R. L. (1987) · Cell · doi:10.1016/0092-8674(87)90497-1 · Cited by 472
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Cited by
Ohlsson, C., Bengtsson, B.-A., Isaksson, O. G. P., Andreassen, T. T., & Slootweg, M. C. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.1.0324 · Cited by 855
Roles of Growth Hormone and Insulin-like Growth Factor 1 in Mouse Postnatal Growth
Lupu, F., Terwilliger, J. D., Lee, K., Segre, G. V., & Efstratiadis, A. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9975 · Cited by 771
Opposing LSD1 complexes function in developmental gene activation and repression programmes
Wang, J., Scully, K., Zhu, X., Cai, L., Zhang, J., Prefontaine, G. G., Krones, A., Ohgi, K. A., Zhu, P., Garcia-Bassets, I., et al. (2007) · Nature · doi:10.1038/nature05671 · Cited by 579
Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice
Saito, M., Iwawaki, T., Taya, C., Yonekawa, H., Noda, M., Inui, Y., Mekada, E., Kimata, Y., Tsuru, A., & Kohno, K. (2001) · Nature Biotechnology · doi:10.1038/90795 · Cited by 512
The Cytogenesis and Pathogenesis of Pituitary Adenomas*
Asa, S. L., & Ezzat, S. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0350 · Cited by 388
Metadata
- Authors
- Behringer, R. R., Mathews, L. S., Palmiter, R. D., & Brinster, R. L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1988-04
- Volume
- 2
- Issue
- 4
- Pages
- 453-461
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2091607263
- Cited by
- 317
- References
- 35
- Type
- posted content
- Language
- en
- Open access
- diamond
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