The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Cooperation between C/EBPα TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation
Open accessAbstract
Chromatin remodeling is an important step in promoter activation during cellular lineage commitment and differentiation. We show that the ability of the C/EBPα transcription factor to direct adipocyte differentiation of uncommitted fibroblast precursors and to activate SWI/SNF-dependent myeloid-specific genes depends on a domain, C/EBPα transactivation element III (TE-III), that binds the SWI/SNF chromatin remodeling complex. TE-III collaborates with C/EBPα TBP/TFIIB interaction motifs during induction of adipogenesis and adipocyte-specific gene expression. These results indicate that C/EBPα acts as a lineage-instructive transcription factor through SWI/SNF-dependent modification of the chromatin structure of lineage-specific genes, followed by direct promoter activation via recruitment of the basal transcription–initiation complex, and provide a mechanism by which C/EBPα can mediate differentiation along multiple cellular lineages.
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Cites
Impaired Energy Homeostasis in C/EBPα Knockout Mice
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DNA binding by c‐Ets‐1, but not v‐Ets, is repressed by an intramolecular mechanism.
Lim, F., Kraut, N., Framptom, J., & Graf, T. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05096.x · Cited by 137
Distinct C/EBP functions are required for eosinophil lineage commitment and maturation
Nerlov, C., McNagny, K. M., Döderlein, G., Kowenz-Leutz, E., & Graf, T. (1998) · Genes & Development · doi:10.1101/gad.12.15.2413 · Cited by 119
Self-citation
Cited by
Adipocyte differentiation from the inside out
Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607
Chromatin remodelling during development
Ho, L., & Crabtree, G. R. (2010) · Nature · doi:10.1038/nature08911 · Cited by 1,114
Disruption of differentiation in human cancer: AML shows the way
Tenen, D. G. (2003) · Nature Reviews Cancer · doi:10.1038/nrc989 · Cited by 612
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
Shi, J., Whyte, W. A., Zepeda-Mendoza, C. J., Milazzo, J. P., Shen, C., Roe, J.-S., Minder, J. L., Mercan, F., Wang, E., Eckersley-Maslin, M. A., et al. (2013) · Genes & Development · doi:10.1101/gad.232710.113 · Cited by 463
Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors
Johnson, P. F. (2005) · Journal of Cell Science · doi:10.1242/jcs.02459 · Cited by 288
Metadata
- Authors
- Pedersen, T. Å., Kowenz-Leutz, E., Leutz, A., & Nerlov, C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-12-01
- Volume
- 15
- Issue
- 23
- Pages
- 3208-3216
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2133162368
- Cited by
- 196
- References
- 6
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Pedersen, T. Å., Kowenz-Leutz, E., Leutz, A., & Nerlov, C. (2001). Cooperation between C/EBPα TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation. Genes & Development. https://doi.org/10.1101/gad.209901
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
