The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.
Adaptive thermogenesis in adipocytes: Is beige the new brown?
Open accessAbstract
One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat. In addition to classical brown adipose tissue, the last few years have seen great advances in our understanding of inducible thermogenic adipose tissue, also referred to as beige fat. A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases.
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“Brite adipocytes can express UCP1 and, as such, can participate in the maintenance of body temperature 90.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [90]
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“This process is characterized by the appearance of brite (from brown‐in‐white) adipocytes, also called beige adipocytes, mainly in subcutaneous WAT.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [90]
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2 retracted
Wenz, T., Rossi, S. G., Rotundo, R. L., Spiegelman, B. M., & Moraes, C. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911570106 · Cited by 600
Self-citationRetractedRomanatto, T., Roman, E. A., Arruda, A. P., Denis, R., Solon, C., Milanski, M., Moraes, J. C., Bonfleur, M. L., Degasperi, G. R., Picardi, P. K., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.030874 · Cited by 156
RetractedBrown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Self-citationIdentification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Self-citationCold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406
Self-citationFunctional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
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Research works printed but not linked: 2
- 1902, On the presence in human embryos of an interscapular gland corresponding to the so-called hibernating gland of lower mammals, Anat Anz, 21, 369
- 10.1172/JCI200421752 · DOI · Paper page
Cited by
Sorted by citations
Brown and beige fat: Development, function and therapeutic potential
Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328
González‐Muniesa, P., Martínez‐González, M. Á., Hu, F. B., Després, J., Matsuzawa, Y., Loos, R. J. F., Moreno, L. A., Bray, G. A., & Martínez, J. A. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.34 · Cited by 1,184
Brown and Beige Fat: Physiological Roles beyond Heat Generation
Kajimura, S., Spiegelman, B. M., & Seale, P. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.007 · Cited by 1,028
Self-citationCohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D., Svensson, K. J., Lo, J. C., Zeng, X., Ye, L., Khandekar, M. J., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.021 · Cited by 889
Self-citationQiu, Y., Nguyen, K. D., Odegaard, J. I., Cui, X., Tian, X., Locksley, R. M., Palmiter, R. D., & Chawla, A. (2014) · Cell · doi:10.1016/j.cell.2014.03.066 · Cited by 888
Metadata
- Authors
- Wu, J., Cohen, P., & Spiegelman, B. M.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-02-01
- Volume
- 27
- Issue
- 3
- Pages
- 234-250
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3576510
- OpenAlex
- W2170874580
- Cited by
- 828
- References
- 204
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 34 · 2023: 37 · 2022: 46 · 2021: 64 · 2020: 64 · 2019: 72 · 2018: 56 · 2017: 91 · 2016: 73 · 2015: 98 · 2014: 91 · 2013: 46
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Foundation for the National Institutes of Health
- American Heart Association
- JPB Foundation
- National Institutes of Health (DK31405)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031405, DK-31405, K01DK094824, RC4DK090861, DK90861, R37DK031405)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- beige adipocytes, brown adipose tissue, thermogenesis, energy expenditure, adaptive thermogenesis, obesity, diabetes mellitus, metabolic disorders, adipogenesis
- MeSH terms
- Uncoupling Protein 1, Adaptation, Physiological, Animals, Adipose Tissue, Brown, Humans, Ion Channels, Obesity, Adipocytes, Gene Expression Regulation, Developmental, Thermogenesis, Mitochondrial Proteins
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