The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Myomaker is essential for muscle regeneration
Open accessAbstract
Regeneration of injured adult skeletal muscle involves fusion of activated satellite cells to form new myofibers. Myomaker is a muscle-specific membrane protein required for fusion of embryonic myoblasts, but its potential involvement in adult muscle regeneration has not been explored. We show that myogenic basic helix–loop–helix (bHLH) transcription factors induce myomaker expression in satellite cells during acute and chronic muscle regeneration. Moreover, genetic deletion of myomaker in adult satellite cells completely abolishes muscle regeneration, resulting in severe muscle destruction after injury. Myomaker is the only muscle-specific protein known to be absolutely essential for fusion of embryonic and adult myoblasts.
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Cites
A conditional knockout resource for the genome-wide study of mouse gene function
Skarnes, W. C., Rosen, B., West, A. P., Koutsourakis, M., Bushell, W., Iyer, V., Mujica, A. O., Thomas, M., Harrow, J., Cox, T., et al. (2011) · Nature · doi:10.1038/nature10163 · Cited by 1,708
Cited by
Satellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140068 · Cited by 719
Skeletal muscle: A review of molecular structure and function, in health and disease
Mukund, K., & Subramaniam, S. (2020) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1462 · Cited by 664
The microprotein Minion controls cell fusion and muscle formation
Zhang, Q., Vashisht, A. A., O’Rourke, J., Corbel, S. Y., Moran, R., Romero, A., Miraglia, L., Zhang, J., Durrant, E., Schmedt, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15664 · Cited by 267
Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development
Quinn, M. E., Goh, Q., Kurosaka, M., Gamage, D. G., Petrany, M. J., Prasad, V., & Millay, D. P. (2017) · Nature Communications · doi:10.1038/ncomms15665 · Cited by 264
Self-citationIL-15 Promotes Human Myogenesis and Mitigates the Detrimental Effects of TNFα on Myotube Development
O’Leary, M. F., Wallace, G. R., Bennett, A. J., Tsintzas, K., & Jones, S. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-13479-w · Cited by 85
Metadata
- Authors
- Millay, D. P., Sutherland, L. B., Bassel-Duby, R., & Olson, E. N.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-08-01
- Volume
- 28
- Issue
- 15
- Pages
- 1641-1646
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2170191823
- Cited by
- 193
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Myomaker is essential for muscle regeneration. https://app.cochat.ai/papers/10.1101/gad.247205.114
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- Millay, D. P., Sutherland, L. B., Bassel-Duby, R., & Olson, E. N. (2014). Myomaker is essential for muscle regeneration. Genes & Development. https://doi.org/10.1101/gad.247205.114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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