The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
RB1: a prototype tumor suppressor and an enigma
Open accessAbstract
The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene to be molecularly defined.RB1 mutations occur in almost all familial and sporadic forms of retinoblastoma, and this gene is mutated at variable frequencies in a variety of other human cancers. Because of its early discovery, the recessive nature of RB1 mutations, and its frequency of inactivation,RB1 is often described as a prototype for the class of tumor suppressor genes. Its gene product (pRB) regulates transcription and is a negative regulator of cell proliferation. Although these general features are well established, a precise description of pRB's mechanism of action has remained elusive. Indeed, in many regards, pRB remains an enigma. This review summarizes some recent developments in pRB research and focuses on progress toward answers for the three fundamental questions that sit at the heart of the pRB literature: What does pRB do? How does the inactivation of RB change the cell? How can our knowledge of RB function be exploited to provide better treatment for cancer patients?
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2 retracted
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The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
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“These tumors develop from progenitor cells that are dependent on Mdm2 (Xu et al. 2009), and, as they also often express high levels of Mdm4 (Laurie et al. 2006), they may be targetable by agents such as Nutlin that activate p53 signaling (Elison et al. 2006; Laurie et al. 2006, 2007).”
BackgroundA human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
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“The development of effective inhibitors for Cdk4/6 kinases has been one of the most impactful applications of pRB research (Fry et al. 2004; for review, see Sherr et al. 2016).”
BackgroundMethodSystematic identification of genomic markers of drug sensitivity in cancer cells
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Cited by
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622
Regulating tumor suppressor genes: post-translational modifications
Chen, L., Liu, S., & Tao, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0196-9 · Cited by 449
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.
Fischer, M., & Müller, G. A. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1360836 · Cited by 255
Biphasic cell cycle defect causes impaired neurogenesis in down syndrome
Sharma, V., Nehra, S., Do, L. H., Ghosh, A., Deshpande, A. J., & Singhal, N. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1007519 · Cited by 14
Metadata
- Authors
- Dyson, N. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-07-01
- Volume
- 30
- Issue
- 13
- Pages
- 1492-1502
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2471978271
- Cited by
- 435
- References
- 151
- Type
- posted content
- Language
- en
- Open access
- diamond
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