The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
Open accessAbstract
Correct establishment of the left/right (L/R) body asymmetry in the mouse embryo requires asymmetric activation of the evolutionarily conserved Nodal signaling cascade in the left lateral plate mesoderm (L-LPM). Furthermore, the presence of Nodal in the node is essential for its own expression in the L-LPM. Here, we have characterized the function of cerl-2 , a novel Nodal antagonist, which displays a unique asymmetric expression on the right side of the mouse node. cerl-2 knockout mice display multiple laterality defects including randomization of the L/R axis. These defects can be partially rescued by removing one nodal allele. Our results demonstrate that Cerl-2 plays a key role in restricting the Nodal signaling pathway toward the left side of the mouse embryo by preventing its activity in the right side.
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Cites
Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759 · cited 1×
“In vitro fertilization, microinjection of Xenopus laevis embryos, and RT–PCR analysis were performed as described previously (Bouwmeester et al. 1996; Belo et al. 2000).”
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Cited by
TGF-β Superfamily Signaling in Embryonic Development and Homeostasis
Wu, M. Y., & Hill, C. S. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.012 · Cited by 746
Bone morphogenetic proteins: a critical review
Bragdon, B., Moseychuk, O., Saldanha, S., King, D., Julian, J., & Nohe, A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.003 · Cited by 691
Secreted and transmembrane wnt inhibitors and activators
Cruciat, C.-M., & Niehrs, C. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015081 · Cited by 646
Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2
Yoshiba, S., Shiratori, H., Kuo, I. Y., Kawasumi, A., Shinohara, K., Nonaka, S., Asai, Y., Sasaki, G., Belo, J. A., Sasaki, H., et al. (2012) · Science · doi:10.1126/science.1222538 · Cited by 306
Self-citationThe left-right axis in the mouse: from origin to morphology
Shiratori, H., & Hamada, H. (2006) · Development · doi:10.1242/dev.02384 · Cited by 301
Metadata
- Authors
- Marques, S., Borges, A. C., Silva, A. C., Freitas, S., Cordenonsi, M., & Belo, J. A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-10-01
- Volume
- 18
- Issue
- 19
- Pages
- 2342-2347
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2100326113
- Cited by
- 180
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Marques, S., Borges, A. C., Silva, A. C., Freitas, S., Cordenonsi, M., & Belo, J. A. (2004). The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes & Development. https://doi.org/10.1101/gad.306504
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