Secreted and transmembrane wnt inhibitors and activators

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204 · see citing works

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235 · see citing works

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

Firth, S. M., & Baxter, R. C. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0033 · Cited by 1,754 · see citing works

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608 · see citing works

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591 · see citing works

Secreted antagonists of the Wnt signalling pathway

Kawano, Y., & Kypta, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00623 · Cited by 1,584 · see citing works

Regulation of bone mass by Wnt signaling

Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407 · see citing works

Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366 · cited 1× · see citing works

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

Little, R. D., Folz, C., Manning, S. P., Swain, P. M., Zhao, S.-C., Eustace, B., Lappe, M. M., Spitzer, L., Zweier, S., Braunschweiger, K., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/338450 · Cited by 1,282 · see citing works

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

de Lau, W., Barker, N., Low, T. Y., Koo, B., Li, V. S. W., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P. J., van de Wetering, M., et al. (2011) · Nature · doi:10.1038/nature10337 · Cited by 1,267 · see citing works

Female development in mammals is regulated by Wnt-4 signalling

Vainio, S. J., Heikkilä, M. M., Kispert, A., Chin, N., & McMahon, A. P. (1999) · Nature · doi:10.1038/17068 · Cited by 1,263 · see citing works

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · see citing works

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

Winkler, D. G., Sutherland, M. K., Geoghegan, J. C., Yu, C., Hayes, T., Skonier, J. E., Shpektor, D., Jonas, M., Kovacevich, B. R., Staehling‐Hampton, K., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg599 · Cited by 1,114 · see citing works

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042 · see citing works

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038 · see citing works

Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein

Brunkow, M. E., Gardner, J. C., Van Ness, J., Paeper, B. W., Kovacevich, B. R., Proll, S., Skonier, J. E., Zhao, L., Sabo, P. J., Fu, Y.-H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/318811 · Cited by 1,011 · see citing works

Function and biological roles of the Dickkopf family of Wnt modulators

Niehrs, C. (2006) · Oncogene · doi:10.1038/sj.onc.1210054 · Cited by 995 · see citing works

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Hao, H.-X., Xie, Y., Zhang, Y., Charlat, O., Oster, E., Avello, M., Lei, H., Mickanin, C., Liu, D., Ruffner, H., et al. (2012) · Nature · doi:10.1038/nature11019 · Cited by 962 · see citing works

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

Li, X., Ominsky, M. S., Niu, Q., Sun, N., Daugherty, B., D’Agostin, D. M., Kurahara, C., Gao, Y., Cao, J., Gong, J., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080216 · Cited by 938 · see citing works

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

Ootani, A., Li, X., Sangiorgi, E., Ho, Q. T., Ueno, H., Toda, S., Sugihara, H., Fujimoto, K., Weissman, I. L., Capecchi, M. R., et al. (2009) · Nature Medicine · doi:10.1038/nm.1951 · Cited by 906 · see citing works

Vascular Development in the Retina and Inner Ear

Xu, Q., Wang, Y., Dabdoub, A., Smallwood, P. M., Williams, J., Woods, C., Kelley, M. W., Jiang, L., Tasman, W., Zhang, K., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00216-8 · Cited by 875 · see citing works

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling

Carmon, K. S., Gong, X. W., Lin, Q., Thomas, A., & Liu, Q. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106083108 · Cited by 857 · see citing works

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, T., & Robertis, E. M. D. (1999) · Nature · doi:10.1038/17820 · Cited by 832 · see citing works

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

Padhi, D., Jang, G. R., Stouch, B., Fang, L., & Posvar, E. L. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.173 · Cited by 786 · see citing works

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772 · see citing works

SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

Semënov, M., Tamai, K., & He, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504308200 · Cited by 771 · see citing works

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O. A., Jenny, A., et al. (2005) · Nature Genetics · doi:10.1038/ng1552 · Cited by 767 · see citing works

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759 · see citing works

R-spondin1 is essential in sex determination, skin differentiation and malignancy

Parma, P., Radi, O., Vidal, V., Chaboissier, M., Dellambra, E., Valentini, S., Guerra, L., Schedl, A., & Camerino, G. (2006) · Nature Genetics · doi:10.1038/ng1907 · Cited by 757 · see citing works

A new secreted protein that binds to Wnt proteins and inhibits their activites

Hsieh, J.-C., Kodjabachian, L., Rebbert, M. L., Rattner, A., Smallwood, P. M., Samos, C. H., Nusse, R., Dawid, I. B., & Nathans, J. (1999) · Nature · doi:10.1038/18899 · Cited by 750 · see citing works

Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer

Leyns, L., Bouwmeester, T., Kim, S., Piccolo, S., & Robertis, E. M. D. (1997) · Cell · doi:10.1016/s0092-8674(00)81921-2 · Cited by 736 · see citing works

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

Semënov, M. V., Tamai, K., Brott, B. K., Kühl, M., Sokol, S. Y., & He, X. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00290-1 · Cited by 700 · see citing works

Identification of a 52 kb deletion downstream of the <i>SOST</i> gene in patients with van Buchem disease

Balemans, W., Patel, N., Ebeling, M., Van Hul, E., Wuyts, W., Lacza, C., Dioszegi, M., Dikkers, F. G., Hildering, P., Willems, P. J., et al. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.2.91 · Cited by 698 · see citing works

DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN <i>XENOPUS</i> EMBRYOS

De Robertis, E. M., & Kuroda, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.011403.154124 · Cited by 671 · see citing works

Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

Bovolenta, P., Esteve, P., Ruiz, J. M., Cisneros, E., & López-Rı́os, J. (2008) · Journal of Cell Science · doi:10.1242/jcs.026096 · Cited by 655 · see citing works

Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse

Mukhopadhyay, M., Shtrom, S., Rodrı́guez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D. W., Glinka, A., Grinberg, A., Huang, S.-P., et al. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00041-7 · Cited by 634 · see citing works

Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium

Kim, K., Kakitani, M., Zhao, J., Oshima, T., Tang, T., Binnerts, M. E., Liu, Y., Boyle, B., Park, E., Emtage, P. C. R., et al. (2005) · Science · doi:10.1126/science.1112521 · Cited by 587 · see citing works

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

Rattner, A., Hsieh, J.-C., Smallwood, P. M., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2859 · Cited by 574 · see citing works

LGR4 and LGR5 are R‐spondin receptors mediating Wnt/β‐catenin and Wnt/PCP signalling

Glinka, A., Dolde, C. E., Kirsch, N., Huang, Y., Kazanskaya, O., Ingelfinger, D., Boutros, M., Cruciat, C., & Niehrs, C. (2011) · EMBO Reports · doi:10.1038/embor.2011.175 · Cited by 565 · see citing works

Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass

Morvan, F., Boulukos, K. E., Clément-Lacroix, P., Roman‐Roman, S., Suc-Royer, I., Vayssière, B., Ammann, P., Martin, P., Pinho, S., Pognonec, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060311 · Cited by 521 · see citing works

Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8

Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518 · cited 2× · see citing works

Activation of -catenin signaling by Rspo1 controls differentiation of the mammalian ovary

Chassot, A., Ranc, F., Gregoire, E. P., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn016 · Cited by 508 · see citing works

Functional and structural diversity of the human Dickkopf gene family

Krupnik, V. E., Sharp, J., Jiang, C., Robison, K. E., Chickering, T. W., Amaravadi, L. S., Brown, D. E., Guyot, D. J., Mays, G. G., Leiby, K. R., et al. (1999) · Gene · doi:10.1016/s0378-1119(99)00365-0 · Cited by 490 · see citing works

Wnt antagonism initiates cardiogenesis in Xenopus laevisPreprint

Schneider, V., & Mercola, M. A. (2001) · Genes & Development · doi:10.1101/gad.855601 · Cited by 483 · see citing works

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

Robitaille, J. M., MacDonald, M. L. E., Kaykas, A., Sheldahl, L. C., Zeisler, J., Dubé, M., Zhang, L., Singaraja, R. R., Guernsey, D. L., Zheng, B., et al. (2002) · Nature Genetics · doi:10.1038/ng957 · Cited by 482 · see citing works

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

Dann, C. E., Hsieh, J.-C., Rattner, A., Sharma, D., Nathans, J., & Leahy, D. J. (2001) · Nature · doi:10.1038/35083601 · Cited by 473 · see citing works

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

Li, J., Sarosi, I., Cattley, R. C., Pretorius, J. K., Asuncion, F., Grisanti, M. S., Morony, S., Adamu, S., Geng, Z., Qiu, W., et al. (2006) · Bone · doi:10.1016/j.bone.2006.03.017 · Cited by 441 · see citing works

R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis

Kazanskaya, O., Glinka, A., del Barco Barrantes, I., Stannek, P., Niehrs, C., & Wu, W. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.019 · Cited by 431 · see citing works

Secreted Frizzled‐related proteins: searching for relationships and patterns

Jones, S. E., & Jomary, C. (2002) · BioEssays · doi:10.1002/bies.10136 · Cited by 427 · see citing works

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

Finch, P. W., He, X., Kelley, M. J., Üren, A., Schaudies, R. P., Popescu, N. C., Rudikoff, S., Aaronson, S. A., VARMUS, H. E., & Rubin, J. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6770 · Cited by 417 · see citing works

Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling

Üren, A., Reichsman, F., Anest, V., Taylor, W. G., Muraiso, K., Bottaro, D. P., Cumberledge, S., & Rubin, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4374 · Cited by 408 · see citing works

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

Fulciniti, M., Tassone, P., Hideshima, T., Vallet, S., Nanjappa, P., Ettenberg, S. A., Shen, Z., Patel, N., Tai, Y., Chauhan, D., et al. (2009) · Blood · doi:10.1182/blood-2008-11-191577 · Cited by 400 · see citing works

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemüller, A. J. M., Caruso, A., Storto, M., Gaviraghi, G., Terstappen, G. C., & Nicoletti, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1381-04.2004 · Cited by 394 · see citing works

TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling

Junge, H. J., Yang, S. C., Burton, J. B., Paes, K., Shu, X., French, D. M., Costa, M., Rice, D. S., & Ye, W. (2009) · Cell · doi:10.1016/j.cell.2009.07.048 · Cited by 391 · see citing works

Mutations in LRP5 or FZD4 Underlie the Common Familial Exudative Vitreoretinopathy Locus on Chromosome 11q

Toomes, C., Bottomley, H. M., Jackson, R. M., Towns, K. V., Scott, S., Mackey, D. A., Craig, J. E., Jiang, L., Yang, Z., Trembath, R. C., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/383202 · Cited by 381 · see citing works

A Wnt Survival Guide: From Flies to Human Disease

Chien, A. J., Conrad, W. H., & Moon, R. T. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.445 · Cited by 377 · see citing works

The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer

González‐Sancho, J. M., Aguilera, Ó., García, J. M., Pendás-Franco, N., Peña, C., Cal, S., de Herreros, A. G., Bonilla, F., & Múñoz, A. (2004) · Oncogene · doi:10.1038/sj.onc.1208303 · Cited by 366 · see citing works

A mutation in the Norrie disease gene (NDP) associated with X–linked familial exudative vitreoretinopathy

Chen, Z.-Y., Battinelli, E. M., Fielder, A. R., et al. (1993) · Nature Genetics · doi:10.1038/ng1093-180 · Cited by 360 · see citing works

Interaction of Frizzled Related Protein (FRP) with Wnt Ligands and the Frizzled Receptor Suggests Alternative Mechanisms for FRP Inhibition of Wnt Signaling

Bafico, A., Gazit, A., Tata, P., Finch, P. W., Yaniv, A., & Aaronson, S. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16180 · Cited by 353 · see citing works

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

Glinka, A., Wu, W., Onichtchouk, D., Blumenstock, C., & Niehrs, C. (1997) · Nature · doi:10.1038/39092 · Cited by 350 · see citing works

Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity

Ellies, D. L., Viviano, B. L., McCarthy, J. J., Rey, J., Itasaki, N., Saunders, S., & Krumlauf, R. K. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060810 · Cited by 350 · see citing works

A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer

Starr, T. K., Allaei, R., Silverstein, K. A. T., Staggs, R. A., Sarver, A. L., Bergemann, T. L., Gupta, M., O’Sullivan, M. G., Matise, I., Dupuy, A. J., et al. (2009) · Science · doi:10.1126/science.1163040 · Cited by 344 · see citing works

R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism

Kim, K.-A., Wagle, M.-C., Tran, K., Zhan, X., Dixon, M., Liu, S., Gros, D., Korver, W., Yonkovich, S., Tomašević, N., et al. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0187 · Cited by 343 · see citing works

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

Li, X., Liu, P., Liu, W., Maye, P. F., Zhang, J., Zhang, Y., Hurley, M. M., Guo, C., Boskey, A. L., Sun, L., et al. (2005) · Nature Genetics · doi:10.1038/ng1614 · Cited by 341 · see citing works

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

Tomizuka, K., Horikoshi, K., Kitada, R., Sugawara, Y., Iba, Y., Kojima, A., Yoshitome, A., Yamawaki, K., Amagai, M., Inoue, A., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn036 · Cited by 340 · see citing works

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

Aguilera, Ó., Fraga, M. F., Ballestar, E., Paz, M. F., Herranz, M., Espada, J., García, J. M., Múñoz, A., Esteller, M., & González‐Sancho, J. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209439 · Cited by 338 · see citing works

Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

Barker, N., & Clevers, H. C. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.002 · Cited by 338 · see citing works

Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling

Houart, C., Caneparo, L., Heisenberg, C., Barth, K. A., Takeuchi, M., & Wilson, S. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00751-1 · Cited by 326 · see citing works

Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signaling

Mao, B., & Niehrs, C. (2003) · Gene · doi:10.1016/s0378-1119(02)01106-x · Cited by 325 · see citing works

SARPs: A family of secreted apoptosis-related proteins

Melkonyan, H. S., Chang, W. C., Shapiro, J. P., Mahadevappa, M., Fitzpatrick, P., Kiefer, M. C., Tomei, L., & Umansky, S. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13636 · Cited by 322 · see citing works

Wise, a context-dependent activator and inhibitor of Wnt signalling

Itasaki, N., Jones, C. M., Mercurio, S., Rowe, A., Domingos, P. M., Smith, J. C., & Krumlauf, R. (2003) · Development · doi:10.1242/dev.00674 · Cited by 321 · see citing works

EctodermalWnt3/β-cateninsignaling is required for the establishment and maintenance of the apical ectodermal ridgePreprint

Barrow, J. R., Thomas, K. R., Boussadia, O., Moore, R. H., Kemler, R., Capecchi, M. R., & McMahon, A. P. (2003) · Genes & Development · doi:10.1101/gad.1044903 · Cited by 299 · see citing works

Regulation of Mammalian Tooth Cusp Patterning by Ectodin

Kassai, Y., Munne, P., Hotta, Y., Penttilä, E., Kavanagh, K. D., Ohbayashi, N., Takada, S., Thesleff, I., Jernvall, J., & Itoh, N. (2005) · Science · doi:10.1126/science.1116848 · Cited by 298 · see citing works

A 52‐kb deletion in the SOST‐MEOX1 intergenic region on 17q12‐q21 is associated with van Buchem disease in the Dutch population

Staehling‐Hampton, K., Proll, S. C., Paeper, B. W., Zhao, L., Charmley, P., Brown, A., Gardner, J. C., Galas, D. J., Schatzman, R. C., Beighton, P., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10401 · Cited by 294 · see citing works

Regionally specific induction by the Spemann–Mangold organizer

Niehrs, C. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1347 · Cited by 294 · see citing works

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

Kelly, O., Pinson, K. I., & Skarnes, W. C. (2004) · Development · doi:10.1242/dev.01137 · Cited by 291 · see citing works

Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression

Nam, J., Turcotte, T. J., Smith, P. F., Choi, S., & Yoon, J. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508324200 · Cited by 288 · see citing works

On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes

Niehrs, C. (2010) · Development · doi:10.1242/dev.039651 · Cited by 283 · see citing works

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

Binnerts, M. E., Kim, K.-A., Bright, J. M., Patel, S. M., Tran, K., Zhou, M., Leung, J., Liu, Y., Lomas, W. E., Dixon, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702305104 · Cited by 282 · see citing works

Syndromic true hermaphroditism due to an R-spondin1 ( RSPO1 ) homozygous mutation

Tomaselli, S., Megiorni, F., Bernardo, C. D., et al. (2007) · Human Mutation · doi:10.1002/humu.20665 · Cited by 280 · see citing works

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

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Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

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