The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d
Open accessAbstract
N6-methyladenosine (m 6 A) is the most abundant mRNA modification in eukaryotes, playing crucial roles in multiple biological processes. m 6 A is catalyzed by the activity of methyltransferase-like 3 (Mettl3), which depends on additional proteins whose precise functions remain poorly understood. Here we identified Zc3h13 (zinc finger CCCH domain-containing protein 13)/Flacc [Fl(2)d-associated complex component] as a novel interactor of m 6 A methyltransferase complex components in Drosophila and mice. Like other components of this complex, Flacc controls m 6 A levels and is involved in sex determination in Drosophila. We demonstrate that Flacc promotes m 6 A deposition by bridging Fl(2)d to the mRNA-binding factor Nito. Altogether, our work advances the molecular understanding of conservation and regulation of the m 6 A machinery.
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Cites
In silico prediction of protein-protein interactions in human macrophages
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Significance analysis of microarrays applied to the ionizing radiation response
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“All MS raw data were deposited in ProteomeXchange (data set PXD00811). iBAQ analysis iBAQ was performed as described in Schwanhausser et al. (2011) to evaluate protein abundances in the MAC and the MACOM in Mettl3 TAP-LC-MS experiments. m6A-RIP Total RNA from mESCs was isolated using Absolutely RNA…”
MethodAndromeda: A Peptide Search Engine Integrated into the MaxQuant Environment
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Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
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Research works printed but not linked: 1
- 10.1073/pnas.1515891112 · doi:10.1073/pnas.1515891112
Cited by
Reading, writing and erasing mRNA methylation
Zaccara, S., Ries, R. J., & Jaffrey, S. R. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0168-5 · Cited by 2,597
The m6A epitranscriptome: transcriptome plasticity in brain development and function
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m6A RNA Methylation Controls Neural Development and Is Involved in Human Diseases
Du, K., Zhang, L., Lee, T., & Sun, T. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1138-1 · Cited by 153
(2023) · doi:10.1101/2023.02.10.528004 · Cited by 2
(2023) · doi:10.7554/elife.87860.2 · Cited by 1
Metadata
- Authors
- Knuckles, P., Lence, T., Haussmann, I. U., Jacob, D., Kreim, N., Carl, S. H., Masiello, I., Hares, T., Villaseñor, R., Hess, D., Andrade-Navarro, M. A., Biggiogera, M., Helm, M., Soller, M., Bühler, M., & Roignant, J.-Y.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2018-03-01
- Volume
- 32
- Issue
- 5-6
- Pages
- 415-429
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2790194840
- Cited by
- 580
- References
- 48
- Type
- posted content
- Language
- en
- Open access
- diamond
- Funders
- Deutsche Forschungsgemeinschaft (RO 4681/5-1)
- Epitran COST action (CA16120)
- Novartis Research Foundation
- Swiss Science Foundation National Centre of Competence in Research RNA and Disease (141735)
- Biotechnology and Biological Sciences Research Council
- DFG (SPP1784)
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- CoChat. (2026). Citation check: Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d. https://app.cochat.ai/papers/10.1101/gad.309146.117
- The paper
- Knuckles, P., Lence, T., Haussmann, I. U., Jacob, D., Kreim, N., Carl, S. H., Masiello, I., Hares, T., Villaseñor, R., Hess, D., Andrade-Navarro, M. A., Biggiogera, M., Helm, M., Soller, M., Bühler, M., & Roignant, J.-Y. (2018). Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d. Genes & Development. https://doi.org/10.1101/gad.309146.117
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
