The m6A epitranscriptome: transcriptome plasticity in brain development and function
Abstract
The field of epitranscriptomics examines the recently deciphered form of gene expression regulation that is mediated by type- and site-specific RNA modifications. Similarly to the role played by epigenetic mechanisms - which operate via DNA and histone modifications - epitranscriptomic modifications are involved in the control of the delicate gene expression patterns that are needed for the development and activity of the nervous system and are essential for basic and higher brain functions. Here we describe the mechanisms that are involved in the writing, erasing and reading of N 6-methyladenosine, the most prevalent internal mRNA modification, and the emerging roles played by N 6-methyladenosine in the nervous system.
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m6A accounts for two-thirds of all RNA modifications that can be written, read, and erased via the actions of a complex network of proteins.
“To date, among all RNA modifications, N6-methyladenosine (m6A) accounts for two-thirds of all RNA modifications that can be “written”, “read”, and “erased” via the actions of a complex network of proteins348,349”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [349]
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- Authors
- Livneh, I., Moshitch-Moshkovitz, S., Amariglio, N., Rechavi, G., & Dominissini, D.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Tel Aviv University (IL)
- Bar-Ilan University (IL)
- Corresponding author
- Dominissini, Dan
- Venue
- Nature Reviews Neuroscience
- Published
- 2019-12-05
- Volume
- 21
- Issue
- 1
- Pages
- 36-51
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2992866845
- Cited by
- 330
- References
- 134
- Citations by year
- 2026: 38 · 2025: 50 · 2024: 49 · 2023: 57 · 2022: 45 · 2021: 70 · 2020: 20
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- N6-methyladenosine, m6A epitranscriptome, RNA methylation, RNA modification, epitranscriptomic regulation, brain development, nervous system function, gene expression regulation, RNA demethylation, RNA demethylase, RNA methyltransferase, RNA-binding proteins
- MeSH terms
- Axon Guidance, Adenosine, Animals, Brain, Gene Expression Regulation, Humans, Neuroglia, RNA, Messenger, Epigenesis, Genetic, Neurogenesis, Transcriptome
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