Cited by 339RNA modifications and cancerRNA regulation and diseaseEpigenetics and DNA Methylation

The m6A epitranscriptome: transcriptome plasticity in brain development and function

Livneh, Ido, Moshitch-Moshkovitz, Sharon, Amariglio, Ninette, Rechavi, Gideon, Dominissini, Dan·2020·Nature Reviews Neuroscience

Abstract

The field of epitranscriptomics examines the recently deciphered form of gene expression regulation that is mediated by type- and site-specific RNA modifications. Similarly to the role played by epigenetic mechanisms - which operate via DNA and histone modifications - epitranscriptomic modifications are involved in the control of the delicate gene expression patterns that are needed for the development and activity of the nervous system and are essential for basic and higher brain functions. Here we describe the mechanisms that are involved in the writing, erasing and reading of N 6-methyladenosine, the most prevalent internal mRNA modification, and the emerging roles played by N 6-methyladenosine in the nervous system.

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Crossref · 10.1038/s41583-019-0244-z

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Authors
Livneh, I., Moshitch-Moshkovitz, S., Amariglio, N., Rechavi, G., & Dominissini, D.
Affiliations
  • Technion – Israel Institute of Technology (IL)
  • Tel Aviv University (IL)
  • Bar-Ilan University (IL)
Corresponding author
Dominissini, Dan
Venue
Nature Reviews Neuroscience
Published
2019-12-05
Volume
21
Issue
1
Pages
36-51
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2992866845
Cited by
330
References
134
Citations by year
2026: 38 · 2025: 50 · 2024: 49 · 2023: 57 · 2022: 45 · 2021: 70 · 2020: 20
FWCI
3.18
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
N6-methyladenosine, m6A epitranscriptome, RNA methylation, RNA modification, epitranscriptomic regulation, brain development, nervous system function, gene expression regulation, RNA demethylation, RNA demethylase, RNA methyltransferase, RNA-binding proteins
MeSH terms
Axon Guidance, Adenosine, Animals, Brain, Gene Expression Regulation, Humans, Neuroglia, RNA, Messenger, Epigenesis, Genetic, Neurogenesis, Transcriptome

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