The DOI matches its Crossref record; 271 of the 271 references it cites were found in a registry or an index.
PRC2 is high maintenance
Open accessAbstract
As the process that silences gene expression ensues during development, the stage is set for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene profiles. PRC2 catalyzes a specific histone posttranslational modification (hPTM) that fosters chromatin compaction. PRC2 also facilitates the inheritance of this hPTM through its self-contained “write and read” activities, key to preserving cellular identity during cell division. As these changes in gene expression occur without changes in DNA sequence and are inherited, the process is epigenetic in scope. Mutants of mammalian PRC2 or of its histone substrate contribute to the cancer process and other diseases, and research into these aberrant pathways is yielding viable candidates for therapeutic targeting. The effectiveness of PRC2 hinges on its being recruited to the proper chromatin sites; however, resolving the determinants to this process in the mammalian case was not straightforward and thus piqued the interest of many in the field. Here, we chronicle the latest advances toward exposing mammalian PRC2 and its high maintenance.
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Cites
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Self-citationCpG islands and the regulation of transcription
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Cited by
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Li, Y., Chen, X., & Lu, C. (2021) · The EMBO Reports · doi:10.15252/embr.202051803 · Cited by 223
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Uncoupled evolution of the Polycomb system and deep origin of non-canonical PRC1
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Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains
Bryan, E., Valsakumar, D., Idigo, N. J., Warburton, M., Webb, K. M., McLaughlin, K. A., Spanos, C., Lenci, S., Major, V., Ambrosi, C., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2024.12.002 · Cited by 16
Metadata
- Authors
- Yu, J.-R., Lee, C.-H., Oksuz, O., Stafford, J. M., & Reinberg, D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2019-05-23
- Volume
- 33
- Issue
- 15-16
- Pages
- 903-935
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2945156762
- Cited by
- 257
- References
- 271
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Yu, J.-R., Lee, C.-H., Oksuz, O., Stafford, J. M., & Reinberg, D. (2019). PRC2 is high maintenance. Genes & Development. https://doi.org/10.1101/gad.325050.119
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