The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis
Open accessAbstract
Pattern-recognition receptors (PRRs) trigger innate immune responses in animals and plants. One such PRR is the flagellin receptor FLS2 in Arabidopsis . Here, we demonstrate that a functional fusion of FLS2 to the green fluorescent protein (GFP) resides in cell membranes of most tissues. Stimulation with the flagellin epitope flg22 induces its transfer into intracellular mobile vesicles, followed by degradation. FLS2 internalization depends on cytoskeleton and proteasome functions, and receptor activation. A variant FLS2 mutated in Thr 867, a potential phosphorylation site, binds flg22 normally, but is impaired in flg22 responses and FLS2 endocytosis. We propose that plant cells regulate pathogen-associated molecular pattern (PAMP)-mediated PRR activities by subcellular compartmentalization.
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Cites
Negative regulation of Toll-like receptor-mediated immune responses
Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509
Actin Assembly and Endocytosis: From Yeast to Mammals
Engqvist-Goldstein, Å. E. Y., & Drubin, D. G. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.093127 · Cited by 572
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
Chuang, T.-H., & Ulevitch, R. J. (2004) · Nature Immunology · doi:10.1038/ni1066 · Cited by 374
Cited by
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Boller, T., & Felix, G. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105346 · Cited by 3,387
Self-citationA flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence
Chinchilla, D., Zipfel, C., Robatzek, S., Kemmerling, B., Nürnberger, T., Jones, J. D. G., Felix, G., & Boller, T. (2007) · Nature · doi:10.1038/nature05999 · Cited by 1,923
Self-citationPlant PRRs and the Activation of Innate Immune Signaling
Macho, A. P., & Zipfel, C. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.028 · Cited by 989
Elicitors, Effectors, and R Genes: The New Paradigm and a Lifetime Supply of Questions
Bent, A. F., & Mackey, D. (2007) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.45.062806.094427 · Cited by 773
Metadata
- Authors
- Robatzek, S., Chinchilla, D., & Boller, T.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-03-01
- Volume
- 20
- Issue
- 5
- Pages
- 537-542
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2072425598
- Cited by
- 751
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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