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Differential activation of Xenopus homeo box genes by mesoderm-inducing growth factors and retinoic acid.
Open accessAbstract
What is the nature of positional information during embryogenesis? By using Xenopus homeo box genes as anteroposterior (A-P) markers, we confirm the findings of others that mesoderm-inducing growth factors and retinoic acid (RA) can provide positional information along the axis of the body. Xenopus tissue culture-mesoderm-inducing factor (XTC-MIF) selectively activates an anteriorly expressed homeo box gene (XlHbox 1), while basic fibroblast growth factor (bFGF) activates selectively a posteriorly expressed homeo box gene (XlHbox 6). RA activates expression of the posterior gene XlHbox 6, but not of XlHbox 1. This activation, however, requires exposure to growth factors. The data suggest that growth factors and RA may cooperate with each other to provide positional information in vertebrates.
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Cited by
Amaya, E., Musci, T. J., & Kirschner, M. W. (1991) · Cell · doi:10.1016/0092-8674(91)90616-7 · Cited by 1,085
Fibroblast Growth Factor Signaling during Early Vertebrate Development
Böttcher, R. T., & Niehrs, C. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0040 · Cited by 540
Molecular Pathways Controlling Heart Development
Olson, E. N., & Srivastava, D. (1996) · Science · doi:10.1126/science.272.5262.671 · Cited by 478
Retinoid signalling in the development of the central nervous system
Maden, M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn963 · Cited by 428
Fibroblast growth factor (FGF) signaling in development and skeletal diseases
Teven, C. M., Farina, E. M., Rivas, J., & Reid, R. R. (2014) · Genes & Diseases · doi:10.1016/j.gendis.2014.09.005 · Cited by 237
Metadata
- Authors
- Cho, K. W., & De Robertis, E. M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1990-11
- Volume
- 4
- Issue
- 11
- Pages
- 1910-1916
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1981213410
- Cited by
- 199
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Cho, K. W., & De Robertis, E. M. (1990). Differential activation of Xenopus homeo box genes by mesoderm-inducing growth factors and retinoic acid. Genes & Development. https://doi.org/10.1101/gad.4.11.1910
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