The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter.
Open accessAbstract
The Drosophila engrailed gene is expressed in the cells of the posterior developmental compartments. To investigate how the engrailed gene is regulated, chimeric genes consisting of fragments of the engrailed promoter and Escherichia coli lacZ were incorporated into the Drosophila germ line by P-element-mediated recombination. Fusion constructs with 7.5 kb of 5'-flanking sequence contain sufficient information to promote expression in most of the embryonic, larval, and imaginal posterior compartments; transformants with smaller fragments of the 5' region do not. Remarkably, of 20 independent transformants with constructs containing more than 1 kb of 5'-flanking DNA, 7 integrated in or around the engrailed locus. These strains inactivate engrailed function to varying degrees, and some express lacZ with a position- and temporal-specific program that is indistinguishable from the normal engrailed gene. Presumably, in these strains, lacZ is expressed in the context of the engrailed promoter.
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Goto, T., Macdonald, P., & Maniatis, T. (1989) · Cell · doi:10.1016/0092-8674(89)90916-1 · Cited by 277
Coleman, K. G., Poole, S. J., Weir, M. P., Soeller, W. C., & Kornberg, T. (1987) · Genes & Development · doi:10.1101/gad.1.1.19 · Cited by 153
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Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581
Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing
Zecca, M., Basler, K., & Struhl, G. (1995) · Development · doi:10.1242/dev.121.8.2265 · Cited by 494
Targeted Gene Replacement in Drosophila Via P Element-Induced Gap Repair
Gloor, G. B., Nassif, N. A., Johnson-Schlitz, D. M., Preston, C. R., & Engels, W. R. (1991) · Science · doi:10.1126/science.1653452 · Cited by 349
Metadata
- Authors
- Hama, C., Ali, Z., & Kornberg, T. B.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1990-07
- Volume
- 4
- Issue
- 7
- Pages
- 1079-1093
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1995154111
- Cited by
- 244
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Hama, C., Ali, Z., & Kornberg, T. B. (1990). Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter. Genes & Development. https://doi.org/10.1101/gad.4.7.1079
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