The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Targeted Gene Replacement in Drosophila Via P Element-Induced Gap Repair
Abstract
Transposable elements of the P family in Drosophila are thought to transpose by a cut-and-paste process that leaves a double-strand gap. The repair of such gaps resulted in the transfer of up to several kilobase pairs of information from a homologous template sequence to the site of P element excision by a process similar to gene conversion. The template was an in vitro-modified sequence that was tested at various genomic positions. Characterization of 123 conversion tracts provided a detailed description of their length and distribution. Most events were continuous conversion tracts that overlapped the P insertion site without concomitant conversion of the template. The average conversion tract was 1379 base pairs, and the distribution of tract lengths fit a simple model of gap enlargement. The conversion events occurred at sufficiently high frequencies to form the basis of an efficient means of directed gene replacement.
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Cited by
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
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Self-citationChemoreceptor co-expression in Drosophila melanogaster olfactory neurons
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Metadata
- Authors
- Gloor, G. B., Nassif, N. A., Johnson-Schlitz, D. M., Preston, C. R., & Engels, W. R.
- Venue
- Science
- Published
- 1991-09-06
- Volume
- 253
- Issue
- 5024
- Pages
- 1110-1117
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965769301
- Cited by
- 349
- References
- 34
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gloor, G. B., Nassif, N. A., Johnson-Schlitz, D. M., Preston, C. R., & Engels, W. R. (1991). Targeted Gene Replacement in Drosophila Via P Element-Induced Gap Repair. Science. https://doi.org/10.1126/science.1653452
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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