Chromatin Remodeling at DNA Double-Strand Breaks

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438 · see citing works

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075 · see citing works

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422 · see citing works

The biology of chromatin remodeling complexes.

Clapier, C. R., & Cairns, B. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.062706.153223 · Cited by 2,384 · see citing works

Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions

Shogren‐Knaak, M. A., Ishii, H., Sun, J.-M., Pazin, M. J., Davie, J., & Peterson, C. L. (2006) · Science · doi:10.1126/science.1124000 · Cited by 1,876 · see citing works

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671 · see citing works

γH2AX and cancer

Bonner, W. M., Redon, C. E., Dickey, J. S., Nakamura, A. J., Sedelnikova, O. A., Solier, S., & Pommier, Y. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2523 · Cited by 1,623 · see citing works

Double-Strand Break End Resection and Repair Pathway Choice

Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,481 · see citing works

Human CtIP promotes DNA end resection

Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature · doi:10.1038/nature06337 · Cited by 1,362 · see citing works

Heterochromatin revisited

Grewal, S. I. S., & Jia, S. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2008 · Cited by 1,263 · see citing works

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

Gibson, B. A., & Kraus, W. L. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3376 · Cited by 1,226 · see citing works

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

Stucki, M., Clapperton, J. A., Mohammad, D. H., Yaffe, M. B., Smerdon, S. J., & Jackson, S. P. (2005) · Cell · doi:10.1016/j.cell.2005.09.038 · Cited by 1,103 · see citing works

Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis

Ikura, T., Ogryzko, V. V., Grigoriev, M., Groisman, R., Wang, J., Horikoshi, M., Scully, R., Qin, J., & Nakatani, Y. (2000) · Cell · doi:10.1016/s0092-8674(00)00051-9 · Cited by 1,029 · see citing works

RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

Huen, M. S. Y., Grant, R. A., Manke, I. A., Minn, K. T., Yu, X., Yaffe, M. B., & Chen, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.041 · Cited by 1,027 · see citing works

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 973 · see citing works

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

Doil, C., Mailand, N., Bekker‐Jensen, S., Ménard, P., Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bártek, J., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.041 · Cited by 938 · see citing works

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

Lavin, M. F. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2514 · Cited by 901 · see citing works

Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

Kolas, N. K., Chapman, J. R., Nakada, S., Ylanko, J., Chahwan, R., Sweeney, F. D., Panier, S., Mendez, M., Wildenhain, J., Thomson, T. M., et al. (2007) · Science · doi:10.1126/science.1150034 · Cited by 900 · see citing works

Histones: annotating chromatin

Campos, E. I., & Reinberg, D. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.032608.103928 · Cited by 852 · see citing works

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., & Jeggo, P. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.017 · Cited by 836 · see citing works

H3.3/H2A.Z double variant–containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions

Jin, C., Zang, C., Wei, G., Cui, K., Peng, W., Zhao, K., & Felsenfeld, G. (2009) · Nature Genetics · doi:10.1038/ng.409 · Cited by 776 · see citing works

Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

Sykes, S. M., Mellert, H. S., Holbert, M. A., Li, K., Marmorstein, R., Lane, W. S., & McMahon, S. B. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.026 · Cited by 752 · see citing works

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

Sun, Y., Jiang, X., Chen, S., Fernandes, N., & Price, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504211102 · Cited by 738 · see citing works

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

Luger, K., Dechassa, M. L., & Tremethick, D. J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3382 · Cited by 738 · see citing works

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D. C., Lukas, J., Bekker-Jensen, S., Bartek, J., & Shiloh, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1446 · Cited by 735 · see citing works

RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

Sobhian, B., Shao, G., Lilli, D. R., Culhane, A. C., Moreau, L. A., Xia, B., Livingston, D. M., & Greenberg, R. A. (2007) · Science · doi:10.1126/science.1139516 · Cited by 672 · see citing works

Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions

Kusch, T., Florens, L. A., McDonald, W. H., Swanson, S. K., Glaser, R. L., Yates, J. R., Abmayr, S. M., Washburn, M. P., & Workman, J. L. (2004) · Science · doi:10.1126/science.1103455 · Cited by 669 · see citing works

Chromatin organization is a major influence on regional mutation rates in human cancer cells

Schuster-Böckler, B., & Lehner, B. (2012) · Nature · doi:10.1038/nature11273 · Cited by 657 · see citing works

MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

Lou, Z., Minter‐Dykhouse, K., Franco, S., Gostissa, M., Rivera, M. A., Celeste, A., Manis, J. P., van Deursen, J., Nussenzweig, A., Paull, T. T., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.025 · Cited by 629 · see citing works

Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

Murr, R., Loizou, J. I., Yang, Y.-G., Cuenin, C., Li, H., Wang, Z.-Q., & Herceg, Z. (2006) · Nature Cell Biology · doi:10.1038/ncb1343 · Cited by 613 · cited 9× · see citing works

Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

Ahel, D., Hořejší, Z., Wiechens, N., Polo, S. E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S. C., Jackson, S. P., et al. (2009) · Science · doi:10.1126/science.1177321 · Cited by 588 · see citing works

Binding of Chromatin-Modifying Activities to Phosphorylated Histone H2A at DNA Damage Sites

Downs, J. A., Allard, S., Jobin‐Robitaille, O., Javaheri, A., Auger, A., Bouchard, N., Kron, S. J., Jackson, S. P., & Côté, J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.12.003 · Cited by 583 · see citing works

Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair

Bird, A. W., Yu, D. Y., Pray-Grant, M. G., Qiu, Q., Harmon, K. E., Megee, P. C., Grant, P. A., Smith, M. M., & Christman, M. F. (2002) · Nature · doi:10.1038/nature01035 · Cited by 565 · see citing works

Nucleosome stability mediated by histone variants H3.3 and H2A.ZPreprint

Jin, C., & Felsenfeld, G. (2007) · Genes & Development · doi:10.1101/gad.1547707 · Cited by 544 · see citing works

Crystal structure of a nucleosome core particle containing the variant histone H2A.Z.

Luger, K., Suto, R. K., Clarkson, M. J., & Tremethick, D. J. (2000) · Nature Structural Biology · doi:10.1038/81971 · Cited by 541 · see citing works

Genome-Wide Dynamics of Htz1, a Histone H2A Variant that Poises Repressed/Basal Promoters for Activation through Histone Loss

Zhang, H., Roberts, D. N., & Cairns, B. R. (2005) · Cell · doi:10.1016/j.cell.2005.08.036 · Cited by 537 · see citing works

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

Chou, D. M., Adamson, B., Dephoure, N. E., Tan, X., Nottke, A. C., Hurov, K. E., Gygi, S. P., Colaiácovo, M. P., & Elledge, S. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012946107 · Cited by 529 · see citing works

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

Kruhlak, M. J., Celeste, A., Dellaire, G., Fernandez-Capetillo, O., Müller, W. G., McNally, J. G., Bazett-Jones, D. P., & Nussenzweig, A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510015 · Cited by 518 · see citing works

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

Chiolo, I., Minoda, A., Colmenares, S. U., Polyzos, A. A., Costes, S. V., & Karpen, G. H. (2011) · Cell · doi:10.1016/j.cell.2011.02.012 · Cited by 516 · see citing works

High‐resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

Iacovoni, J. S., Caron, P., Lassadi, I., Nicolas, E., Massip, L., Trouche, D., & Legube, G. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.38 · Cited by 515 · see citing works

Positional stability of single double-strand breaks in mammalian cells

Soutoglou, E., Dorn, J. F., Sengupta, K., Jasin, M., Nussenzweig, A., Ried, T., Danuser, G., & Misteli, T. (2007) · Nature Cell Biology · doi:10.1038/ncb1591 · Cited by 509 · see citing works

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mousePreprint

Schotta, G., Sengupta, R., Kubicek, S., Malin, S., Kauer, M., Callén, E., Celeste, A., Pagani, M., Opravil, S., Rosa-Velázquez, I. A. D. L., et al. (2008) · Genes & Development · doi:10.1101/gad.476008 · Cited by 455 · see citing works

Global Regulation of H2A.Z Localization by the INO80 Chromatin-Remodeling Enzyme Is Essential for Genome Integrity

Papamichos‐Chronakis, M., Watanabe, S., Rando, O. J., & Peterson, C. L. (2011) · Cell · doi:10.1016/j.cell.2010.12.021 · Cited by 455 · see citing works

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

Sun, Y., Jiang, X., Xu, Y., Ayrapetov, M. K., Moreau, L. A., Whetstine, J. R., & Price, B. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1982 · Cited by 454 · see citing works

Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae

Tsukuda, T., Fleming, A. B., Nickoloff, J. A., & Osley, M. A. (2005) · Nature · doi:10.1038/nature04148 · Cited by 426 · see citing works

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Pei, H., Zhang, L. M., Luo, K., Qin, Y., Chesi, M., Fei, Y. F., Bergsagel, P. L., Wang, L., You, Z., & Lou, Z. (2011) · Nature · doi:10.1038/nature09658 · Cited by 412 · see citing works

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

Ayoub, N., Jeyasekharan, A. D. D., Bernal, J. A., & Venkitaraman, A. R. (2008) · Nature · doi:10.1038/nature06875 · Cited by 404 · see citing works

DNA resection in eukaryotes: deciding how to fix the break

Huertas, P. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1710 · Cited by 398 · see citing works

The highly conserved and multifunctional NuA4 HAT complex

Doyon, Y., & Côté, J. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.02.009 · Cited by 386 · see citing works

DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N. K., Amunugama, R., Yoder, K. E., Izumi, S., Kuraoka, I., Tanaka, K., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00579-07 · Cited by 376 · see citing works

Regulation of DNA‐damage responses and cell‐cycle progression by the chromatin remodelling factor CHD4

Polo, S. E., Kaidi, A., Baskcomb, L., Galanty, Y., & Jackson, S. P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.188 · Cited by 374 · cited 5× · see citing works

KAP1 Protein: An Enigmatic Master Regulator of the Genome

Iyengar, S., & Farnham, P. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.252569 · Cited by 367 · see citing works

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

Gottschalk, A. J., Timinszky, G., Kong, S. E., Jin, J., Cai, Y., Swanson, S. K., Washburn, M. P., Florens, L. A., Ladurner, A. G., Conaway, J. W., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906920106 · Cited by 358 · see citing works

Prime, Repair, Restore: The Active Role of Chromatin in the DNA Damage Response

Soria, G., Polo, S. E., & Almouzni, G. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.002 · Cited by 342 · see citing works

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

Gorrini, C., Squatrito, M., Luise, C., Syed, N., Perna, D., Wark, L., Martinato, F., Sardella, D., Verrecchia, A., Bennett, S., et al. (2007) · Nature · doi:10.1038/nature06055 · Cited by 341 · see citing works

Chromosome-wide Rad51 Spreading and SUMO-H2A.Z-Dependent Chromosome Fixation in Response to a Persistent DNA Double-Strand Break

Kalocsay, M., Hiller, N. J., & Jentsch, S. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.016 · Cited by 340 · see citing works

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

Noon, A. T., Shibata, A., Rief, N., Löbrich, M., Stewart, G. S., Jeggo, P. A., & Goodarzi, A. A. (2010) · Nature Cell Biology · doi:10.1038/ncb2017 · Cited by 339 · see citing works

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

Guðjόnsson, Þ., Altmeyer, M., Savic, V., Toledo, L. I., Dinant, C., Grøfte, M., Bártková, J., Poulsen, M., Oka, Y., Bekker‐Jensen, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.039 · Cited by 338 · see citing works

Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair

Xu, Y., Ayrapetov, M. K., Xu, C., Gursoy-Yuzugullu, O., Hu, Y., & Price, B. D. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.026 · Cited by 336 · see citing works

Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double‐strand breaks

van Attikum, H., Fritsch, O., & Gasser, S. M. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601835 · Cited by 333 · see citing works

The p400 Complex Is an Essential E1A Transformation Target

Fuchs, M., Gerber, J. D., Drapkin, R., Sif, S., Ikura, T., Ogryzko, V. V., Lane, W. S., Nakatani, Y., & Livingston, D. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00450-0 · Cited by 328 · see citing works

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

Jakob, B., Splinter, J., Conrad, S., Voss, K., Zink, D., Durante, M., Löbrich, M., & Taucher-Scholz, G. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr230 · Cited by 312 · see citing works

30 nm Chromatin Fibre Decompaction Requires both H4-K16 Acetylation and Linker Histone Eviction

Robinson, P. J. J., An, W., Routh, A. L., Martino, F., Chapman, L., Roeder, R. G., & Rhodes, D. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.04.050 · Cited by 311 · see citing works

H2A.Z Alters the Nucleosome Surface to Promote HP1α-Mediated Chromatin Fiber Folding

Fan, J. Y., Rangasamy, D., Luger, K., & Tremethick, D. J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.023 · Cited by 305 · see citing works

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

Difilippantonio, S., Gapud, E. J., Wong, N., Huang, C., Mahowald, G. K., Chen, H. T., Kruhlak, M. J., Callén, E., Livák, F., Nussenzweig, M. C., et al. (2008) · Nature · doi:10.1038/nature07476 · Cited by 302 · see citing works

Phospho‐dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

Chapman, J. R., & Jackson, S. P. (2008) · EMBO Reports · doi:10.1038/embor.2008.103 · Cited by 285 · see citing works

DNA Repair Pathways in Clinical Practice: Lessons From Pediatric Cancer Susceptibility Syndromes

Kennedy, R. D., & D’Andrea, A. D. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.4171 · Cited by 283 · see citing works

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

Bothmer, A., Robbiani, D. F., Feldhahn, N., Gazumyan, A., Nussenzweig, A., & Nussenzweig, M. C. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100244 · Cited by 283 · see citing works

H2A.Z: View from the Top

Zlatanova, J. S., & Thakar, A. (2008) · Structure · doi:10.1016/j.str.2007.12.008 · Cited by 267 · see citing works

p21 transcription is regulated by differential localization of histone H2A.ZPreprint

Gévry, N. Y., Chan, H. M., Laflamme, L., Livingston, D. M., & Gaudreau, L. R. (2007) · Genes & Development · doi:10.1101/gad.1545707 · Cited by 267 · see citing works

Heterochromatin protein 1 is recruited to various types of DNA damage

Luijsterburg, M. S., Dinant, C., Lans, H., Stap, J., Wiernasz, E., Lagerwerf, S., Warmerdam, D. O., Lindh, M., Brink, M. C., Dobrucki, J. W., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200810035 · Cited by 264 · see citing works

Heterochromatin is refractory to γ-H2AX modification in yeast and mammals

Kim, J., Kruhlak, M. J., Dotiwala, F., Nussenzweig, A., & Haber, J. E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612031 · Cited by 260 · see citing works

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

Goodarzi, A. A., Kurka, T., & Jeggo, P. A. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2077 · Cited by 255 · see citing works

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

Smeenk, G., Wiegant, W. W., Vrolijk, H., Solari, A. P., Pastink, A., & van Attikum, H. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001048 · Cited by 243 · see citing works

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

Larsen, D. H., Poinsignon, C., Guðjόnsson, Þ., Dinant, C., Payne, M., Hari, F. J., Danielsen, J. M. R., Ménard, P., Sand, J. C., Stucki, M., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200912135 · Cited by 241 · see citing works

Global chromatin compaction limits the strength of the DNA damage response

Murga, M., Jaco, I., Fan, Y., Soria, R., Martínez-Pastor, B., Cuadrado, M., Yang, S.-M., Blasco, M. A., Skoultchi, A. I., & Fernández-Capetillo, Ó. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704140 · Cited by 236 · see citing works

A New Fluorescence Resonance Energy Transfer Approach Demonstrates That the Histone Variant H2AZ Stabilizes the Histone Octamer within the Nucleosome

Park, Y., Dyer, P. N., Tremethick, D. J., & Luger, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313152200 · Cited by 231 · see citing works

Tip60: Connecting chromatin to DNA damage signaling

Sun, Y., Jiang, X., & Price, B. D. (2010) · Cell Cycle · doi:10.4161/cc.9.5.10931 · Cited by 230 · see citing works

DNA repair and the role of chromatin structure

Smerdon, M. J. (1991) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(91)90069-b · Cited by 227 · see citing works

Genome-wide profiling of salt fractions maps physical properties of chromatinPreprint

Henikoff, S., Henikoff, J. G., Sakai, A., Loeb, G. B., & Ahmad, K. (2008) · Genome Research · doi:10.1101/gr.087619.108 · Cited by 227 · see citing works

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin

Melander, F., Bekker‐Jensen, S., Falck, J., Bártek, J., Mailand, N., & Lukas, J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708210 · Cited by 226 · see citing works

Epigenetic regulation of heterochromatic DNA stability

Peng, J. C., & Karpen, G. H. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.01.021 · Cited by 209 · see citing works

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

Savic, V., Yin, B., Maas, N. L., Bredemeyer, A. L., Carpenter, A. C., Helmink, B. A., Yang-Iott, K. S., Sleckman, B. P., & Bassing, C. H. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.012 · Cited by 204 · see citing works

HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

Baldeyron, C., Soria, G., Roche, D., Cook, A. J. L., & Almouzni, G. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201101030 · Cited by 200 · see citing works

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

Xu, Y., Sun, Y., Jiang, X., Ayrapetov, M. K., Moskwa, P., Yang, S., Weinstock, D. M., & Price, B. D. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001160 · Cited by 194 · see citing works

Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptationin response to DNA damagePreprint

Papamichos-Chronakis, M., Krebs, J. E., & Peterson, C. L. (2006) · Genes & Development · doi:10.1101/gad.1440206 · Cited by 191 · see citing works

Chromatin remodeling complexes: strength in diversity, precision through specialization

Cairns, B. R. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.01.003 · Cited by 174 · see citing works

Chromatin dynamics and the repair of DNA double strand breaks

Xu, Y., & Price, B. D. (2011) · Cell Cycle · doi:10.4161/cc.10.2.14543 · Cited by 166 · see citing works

Orchestration of chromatin-based processes: mind the TRRAP

Murr, R., Vaissière, T., Sawan, C., Shukla, V., & Herceg, Z. (2007) · Oncogene · doi:10.1038/sj.onc.1210605 · Cited by 163 · see citing works

Human Rvb1/Tip49 Is Required for the Histone Acetyltransferase Activity of Tip60/NuA4 and for the Downregulation of Phosphorylation on H2AX after DNA Damage

Jha, S., Shibata, E., & Dutta, A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01983-07 · Cited by 163 · see citing works

Chromatin mobility is increased at sites of DNA double-strand breaks

Krawczyk, P. M., Borovski, T., Stap, J., Cijsouw, T., ten Cate, R., Medema, J. P., Kanaar, R., Franken, N. A. P., & Aten, J. A. (2012) · Journal of Cell Science · doi:10.1242/jcs.089847 · Cited by 152 · see citing works

H2A.Z nucleosomes enriched over active genes are homotypic

Weber, C. M., Henikoff, J. G., & Henikoff, S. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1926 · Cited by 130 · see citing works

Chromatin-Associated Periodicity in Genetic Variation Downstream of Transcriptional Start Sites

Sasaki, S., Mello, C. C., Shimada, A., Nakatani, Y., Hashimoto, S., Ogawa, M., Matsushima, K., Gu, S. G., Kasahara, M., Ahsan, B., et al. (2008) · Science · doi:10.1126/science.1163183 · Cited by 127 · see citing works

H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy

Bewersdorf, J., Bennett, B. T., & Knight, K. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608709103 · Cited by 121 · see citing works

Distribution of ultraviolet-induced DNA repair synthesis in nuclease sensitive and resistant regions of human chromatin

Smerdon, M. J., Tlsty, T. D., & Lieberman, M. W. (1978) · Biochemistry · doi:10.1021/bi00605a020 · Cited by 117 · see citing works

Precise deposition of histone H2A.Z in chromatin for genome expression and maintenance

Billon, P., & Côté, J. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.10.004 · Cited by 111 · see citing works

The SWR1 Histone Replacement Complex Causes Genetic Instability and Genome-Wide Transcription Misregulation in the Absence of H2A.Z

Morillo‐Huesca, M., Clemente‐Ruiz, M., Andújar, E., & Prado, F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012143 · Cited by 109 · see citing works

Nucleosomes Suppress Spontaneous Mutations Base-Specifically in Eukaryotes

Chen, X., Chen, Z., Chen, H., Su, Z., Yang, J., Lin, F., Shi, S., & He, X. (2012) · Science · doi:10.1126/science.1217580 · Cited by 103 · see citing works

Spreading of mammalian DNA‐damage response factors studied by ChIP‐chip at damaged telomeres

Meier, A., Fiegler, H., Muñoz, P., Ellis, P., Rigler, D., Langford, C., Blasco, M. A., Carter, N., & Jackson, S. P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601719 · Cited by 95 · see citing works

The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks

Courilleau, C., Chailleux, C., Jauneau, A., Grimal, F., Briois, S., Boutet-Robinet, E. A., Boudsocq, F., Trouche, D., & Canitrot, Y. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201205059 · Cited by 79 · see citing works

Impact of chromatin structure on sequence variability in the human genome

Tolstorukov, M. Y., Volfovsky, N., Stephens, R. M., & Park, P. J. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2012 · Cited by 71 · see citing works

Chromatin domains in higher eukaryotes: insights from genome-wide mapping studies

de Wit, E., & van Steensel, B. (2008) · Chromosoma · doi:10.1007/s00412-008-0186-0 · Cited by 55 · see citing works

Mechanisms of DNA damage, repair, and mutagenesis

Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039 · see citing works

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

Ray Chaudhuri, A., & Nussenzweig, A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.53 · Cited by 1,786 · see citing works

DNA damage and its links to neurodegeneration

Madabhushi, R., Pan, L., & Tsai, L.-H. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.034 · Cited by 654 · see citing works

Heterochromatin: Guardian of the Genome

Janssen, A., Colmenares, S. U., & Karpen, G. H. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062653 · Cited by 500 · see citing works

mRNA-based cancer therapeutics

Liu, C., Shi, Q., Huang, X., Koo, S., Kong, N., & Tao, W. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-023-00586-2 · Cited by 500 · see citing works

Non-histone protein methylation as a regulator of cellular signalling and function

Biggar, K. K., & Li, S. S.-C. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3915 · Cited by 479 · see citing works

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

Ayrapetov, M. K., Gursoy-Yuzugullu, O., Xu, C., Xu, Y., & Price, B. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403565111 · Cited by 391 · see citing works

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

Wan, D., Jiang, W., & Hao, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00615 · Cited by 270 · see citing works

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

Gong, F., Chiu, L.-Y., Cox, B., Aymard, F., Clouaire, T., Leung, J. W., Cammarata, M., Perez, M., Agarwal, P., Brodbelt, J. S., et al. (2015) · Genes & Development · doi:10.1101/gad.252189.114 · Cited by 247 · see citing works

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

Khurana, S., Kruhlak, M. J., Kim, J., Tran, A. D., Liu, J., Nyswaner, K., Shi, L., Jailwala, P., Sung, M.-H., Hakim, O., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.024 · Cited by 220 · see citing works

Activation of DNA Damage Response Signaling by Condensed Chromatin

Burgess, R. C., Burman, B., Kruhlak, M. J., & Misteli, T. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.060 · Cited by 198 · see citing works

Regulation of DNA Repair Mechanisms: How the Chromatin Environment Regulates the DNA Damage Response

Stadler, J., & Richly, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081715 · Cited by 110 · see citing works

Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway.

Dar, A., Shibata, E., & Dutta, A. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00358-13 · Cited by 83 · see citing works

Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence

Isermann, A., Mann, C., & Rübe, C. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239130 · Cited by 54 · see citing works

Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability

Zhang, Y., Chang, J.-F., Sun, J., Chen, L., Yang, X.-M., Tang, H.-Y., Jing, Y.-Y., Kang, X., He, Z.-M., Wu, J.-Y., et al. (2018) · Journal of Cell Science · doi:10.1242/jcs.215525 · Cited by 45 · see citing works

The role of progesterone-induced blocking factor (PIBF) in invasion of primary ovarian tumour cells

Balassa, T., Berta, G., Bohonyi, N., et al. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.07.027

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

Cellular Responses to DNA Damage

Klapacz, J., & Gollapudi, B. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95611-3 · Cited by 2 · see citing works

DNA damage repair and cardiovascular diseases

Shukla, P. C., Singh, K. K., Yanagawa, B., Teoh, H., & Verma, S. (2010) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(10)71055-2 · Cited by 45 · see citing works

Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging

Akbari, M., & Krokan, H. E. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.01.007 · Cited by 41 · see citing works