Heterochromatin: Guardian of the Genome

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216 · see citing works

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works

Transposable elements and the epigenetic regulation of the genome

Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044 · see citing works

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009 · see citing works

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

Guelen, L., Pagie, L., Brasset, É., Meuleman, W. R. A., Faza, M. B., Talhout, W., Eussen, B. H. J., de Klein, A., Wessels, L. F. A., de Laat, W. L., et al. (2008) · Nature · doi:10.1038/nature06947 · Cited by 1,959 · see citing works

Phase separation drives heterochromatin domain formation

Strom, A. R., Emelyanov, A. V., Mir, M., Fyodorov, D. V., Darzacq, X., & Karpen, G. H. (2017) · Nature · doi:10.1038/nature22989 · Cited by 1,813 · see citing works

Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

Peters, A. H. F. M., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schöfer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00542-6 · Cited by 1,766 · see citing works

The impact of retrotransposons on human genome evolution

Cordaux, R., & Batzer, M. (2009) · Nature reviews genetics · doi:10.1038/nrg2640 · Cited by 1,691 · see citing works

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Larson, A. G., Elnatan, D., Keenen, M. M., Trnka, M., Johnston, J. B., Burlingame, A., Agard, D., Redding, S., & Narlikar, G. J. (2017) · Nature · doi:10.1038/nature22822 · Cited by 1,554 · see citing works

Epigenetic plasticity and the hallmarks of cancer

Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340 · see citing works

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

Black, J. C., Rechem, C. V., & Whetstine, J. R. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.006 · Cited by 1,318 · see citing works

Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase

Jackson, J. P., Lindroth, A. M., Cao, X.-F., & Jacobsen, S. (2002) · Nature · doi:10.1038/nature731 · Cited by 1,291 · see citing works

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesisPreprint

Tachibana, M., Sugimoto, K., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Kato, H., et al. (2002) · Genes & Development · doi:10.1101/gad.989402 · Cited by 1,261 · see citing works

Suv39h-Mediated Histone H3 Lysine 9 Methylation Directs DNA Methylation to Major Satellite Repeats at Pericentric Heterochromatin

Lehnertz, B., Ueda, Y., Derijck, A. A. H. A., Braunschweig, U., Perez-Burgos, L., Kubicek, S., Chen, T., Li, E., Jenuwein, T., & Peters, A. H. F. M. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00432-9 · Cited by 1,248 · see citing works

DNA breaks and chromosome pulverization from errors in mitosis

Crasta, K., Ganem, N. J., Dagher, R., Lantermann, A. B., Ivanova, E. V., Pan, Y., Nezi, L., Protopopov, A., Chowdhury, D., & Pellman, D. (2012) · Nature · doi:10.1038/nature10802 · Cited by 1,227 · see citing works

Lamin A-Dependent Nuclear Defects in Human Aging

Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,224 · see citing works

Oncogene-induced senescence as an initial barrier in lymphoma development

Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H. F. M., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2005) · Nature · doi:10.1038/nature03841 · Cited by 1,220 · see citing works

Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin

Peters, A. H. F. M., Kubicek, S., Mechtler, K., O’Sullivan, R. J., Derijck, A. A. H. A., Perez-Burgos, L., Kohlmaier, A., Opravil, S., Tachibana, M., Shinkai, Y., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00477-5 · Cited by 1,148 · see citing works

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatinPreprint

Schotta, G., Lachner, M., Sarma, K., Ebert, A., Sengupta, R., Reuter, G., Reinberg, D., & Jenuwein, T. (2004) · Genes & Development · doi:10.1101/gad.300704 · Cited by 1,110 · see citing works

Repetitive Elements May Comprise Over Two-Thirds of the Human Genome

de Koning, A. P. J., Gu, W., Castoe, T. A., Batzer, M. A., & Pollock, D. D. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002384 · Cited by 1,099 · see citing works

A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

Tamaru, H., & Selker, E. U. (2001) · Nature · doi:10.1038/35104508 · Cited by 1,038 · see citing works

Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells

Meshorer, E., Yellajoshyula, D., George, E. M., Scambler, P. J., Brown, D. T., & Misteli, T. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.10.017 · Cited by 1,008 · see citing works

Repeat instability: mechanisms of dynamic mutations

Pearson, C. E., Edamura, K. N., & Cleary, J. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1689 · Cited by 924 · see citing works

Interplay between the Cancer Genome and Epigenome

Shen, H., & Laird, P. W. (2013) · Cell · doi:10.1016/j.cell.2013.03.008 · Cited by 912 · see citing works

Telomere maintenance by recombination in human cells

Dunham, M. A., Neumann, A. A., Fasching, C. L., & Reddel, R. R. (2000) · Nature Genetics · doi:10.1038/82586 · Cited by 879 · see citing works

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

Feinberg, A. P., Koldobskiy, M. A., & Göndör, A. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.13 · Cited by 878 · see citing works

KAP1 controls endogenous retroviruses in embryonic stem cells

Rowe, H. M., Jakobsson, J., Mesnard, D., Rougemont, J., Reynard, S., Aktas, T., Maillard, P. V., Layard-Liesching, H., Verp, S., Marquis, J., et al. (2010) · Nature · doi:10.1038/nature08674 · Cited by 874 · see citing works

Replication stress links structural and numerical cancer chromosomal instability

Burrell, R. A., McClelland, S. E., Endesfelder, D., Groth, P., Weller, M.-C., Shaikh, N., Domingo, E., Kanu, N., Dewhurst, S. M., Gronroos, E. C., et al. (2013) · Nature · doi:10.1038/nature11935 · Cited by 868 · see citing works

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9Preprint

Tachibana, M., Ueda, J., Fukuda, M., Takeda, N., Ohta, T., Iwanari, H., Sakihama, T., Kodama, T., Hamakubo, T., & Shinkai, Y. (2005) · Genes & Development · doi:10.1101/gad.1284005 · Cited by 853 · see citing works

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., & Jeggo, P. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.017 · Cited by 836 · see citing works

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

Lewis, P., Elsaesser, S. J., Noh, K., Stadler, S., & Allis, C. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1008850107 · Cited by 830 · see citing works

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791 · see citing works

Maintaining genome stability at the replication fork

Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786 · see citing works

Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution

Solovei, I. V., Kreysing, M., Lanctôt, C., Kösem, S., Peichl, L., Cremer, T. J., Guck, J. R., & Joffe, B. I. (2009) · Cell · doi:10.1016/j.cell.2009.01.052 · Cited by 785 · see citing works

Ten principles of heterochromatin formation and function

Allshire, R. C., & Madhani, H. D. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.119 · Cited by 783 · see citing works

Landscape of Somatic Retrotransposition in Human Cancers

Lee, E., Iskow, R., Yang, L., Gokcumen, O., Haseley, P., Luquette, L. J., Lohr, J. G., Harris, C. C., Ding, L., Wilson, R. K., et al. (2012) · Science · doi:10.1126/science.1222077 · Cited by 762 · see citing works

Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin

Hirota, T., Lipp, J., Toh, B., & Peters, J. (2005) · Nature · doi:10.1038/nature04254 · Cited by 662 · see citing works

Chromatin organization is a major influence on regional mutation rates in human cancer cells

Schuster-Böckler, B., & Lehner, B. (2012) · Nature · doi:10.1038/nature11273 · Cited by 657 · see citing works

Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component

Maison, C., Bailly, D., Peters, A. H. F. M., Quivy, J., Roche, D. M. J., Taddei, A., Lachner, M., Jenuwein, T., & Almouzni, G. (2002) · Nature Genetics · doi:10.1038/ng843 · Cited by 651 · see citing works

Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene.

James, T. C., & Elgin, S. C. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.11.3862 · Cited by 643 · see citing works

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

Lovejoy, C. A., Li, W., Reisenweber, S., Thongthip, S., Bruno, J., de Lange, T., De, S., Petrini, J. H. J., Sung, P. A., Jasin, M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002772 · Cited by 629 · see citing works

Requirement of Heterochromatin for Cohesion at Centromeres

Bernard, P., Maure, J.-F., Partridge, J. F., Genier, S., Javerzat, J., & Allshire, R. C. (2001) · Science · doi:10.1126/science.1064027 · Cited by 617 · see citing works

DNA methyltransferases control telomere length and telomere recombination in mammalian cells

Gonzalo, S., Jaco, I., Fraga, M. F., Chen, T., Li, E., Esteller, M., & Blasco, M. A. (2006) · Nature Cell Biology · doi:10.1038/ncb1386 · Cited by 604 · see citing works

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

Li, F., Mao, G., Tong, D., Huang, J., Gu, L., Yang, W., & Li, G. (2013) · Cell · doi:10.1016/j.cell.2013.03.025 · Cited by 591 · see citing works

Chromatin Remodeling at DNA Double-Strand Breaks

Price, B. D., & D’Andrea, A. D. (2013) · Cell · doi:10.1016/j.cell.2013.02.011 · Cited by 588 · see citing works

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

Janssen, A., van der Burg, M. J., Szuhai, K., Kops, G. J. P. L., & Medema, R. H. (2011) · Science · doi:10.1126/science.1210214 · Cited by 582 · see citing works

Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin

Sullivan, B. A., & Karpen, G. H. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb845 · Cited by 575 · see citing works

Transposable elements in cancer

Burns, K. H. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.35 · Cited by 572 · see citing works

The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.

Paro, R., & Hogness, D. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.263 · Cited by 562 · see citing works

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

García‐Cao, M., O’Sullivan, R. J., Peters, A. H. F. M., Jenuwein, T., & Blasco, M. A. (2003) · Nature Genetics · doi:10.1038/ng1278 · Cited by 557 · see citing works

Cell-of-origin chromatin organization shapes the mutational landscape of cancer

Polak, P., Karlić, R., Koren, A., Thurman, R., Sandstrom, R., Lawrence, M. S., Reynolds, A., Rynes, E., Vlahoviček, K., Stamatoyannopoulos, J. A., et al. (2015) · Nature · doi:10.1038/nature14221 · Cited by 557 · see citing works

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., et al. (2015) · Science · doi:10.1126/science.aaa1356 · Cited by 551 · see citing works

The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology

McStay, B., & Grummt, I. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175259 · Cited by 527 · see citing works

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

Chiolo, I., Minoda, A., Colmenares, S. U., Polyzos, A. A., Costes, S. V., & Karpen, G. H. (2011) · Cell · doi:10.1016/j.cell.2011.02.012 · Cited by 516 · see citing works

Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila

Dorer, D. R. (1994) · Cell · doi:10.1016/0092-8674(94)90439-1 · Cited by 504 · see citing works

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

Zhu, Q., Pao, G. M., Huynh, A. M., Suh, H., Tonnu, N. U., Nederlof, P. M., Gage, F. H., & Verma, I. M. (2011) · Nature · doi:10.1038/nature10371 · Cited by 486 · see citing works

H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes

Becker, J. S., Nicetto, D., & Zaret, K. S. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.11.001 · Cited by 480 · see citing works

Causes of genome instability

Aguilera, A., & García-Muse, T. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133232 · Cited by 476 · see citing works

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

Arora, R., Lee, Y., Wischnewski, H., Brun, C. M., Schwarz, T., & Azzalin, C. M. (2014) · Nature Communications · doi:10.1038/ncomms6220 · Cited by 468 · see citing works

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mousePreprint

Schotta, G., Sengupta, R., Kubicek, S., Malin, S., Kauer, M., Callén, E., Celeste, A., Pagani, M., Opravil, S., Rosa-Velázquez, I. A. D. L., et al. (2008) · Genes & Development · doi:10.1101/gad.476008 · Cited by 455 · see citing works

Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast

Nonaka, N., Kitajima, T. S., Yokobayashi, S., Xiao, G., Yamamoto, M. P., Grewal, S. I. S., & Watanabe, Y. (2001) · Nature Cell Biology · doi:10.1038/ncb739 · Cited by 455 · see citing works

Functional mammalian homologues of the Drosophila PEV‐modifier Su(var)3‐9 encode centromere‐associated proteins which complex with the heterochromatin component M31

Aagaard, L., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P. B., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1923 · Cited by 441 · see citing works

Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

Tubio, J. M. C., Li, Y., Ju, Y. S., Martincorena, I., Cooke, S. L., Tojo, M., Gundem, G., Pipinikas, C. P., Zamora, J., Raine, K., et al. (2014) · Science · doi:10.1126/science.1251343 · Cited by 412 · see citing works

Non-B DNA structure-induced genetic instability and evolution

Zhao, J., Bacolla, A., Wang, G., & Vásquez, K. M. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0131-2 · Cited by 405 · see citing works

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

Ayoub, N., Jeyasekharan, A. D. D., Bernal, J. A., & Venkitaraman, A. R. (2008) · Nature · doi:10.1038/nature06875 · Cited by 404 · see citing works

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

Ayrapetov, M. K., Gursoy-Yuzugullu, O., Xu, C., Xu, Y., & Price, B. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403565111 · Cited by 391 · see citing works

The Smc5–Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus

Torres‐Rosell, J., Šunjevarić, I., Piccoli, G. D., Sacher, M., Eckert‐Boulet, N., Reid, R. J. D., Jentsch, S., Rothstein, R. J., Aragón, L., & Lisby, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1619 · Cited by 379 · see citing works

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cellsPreprint

Fodor, B. D., Kubicek, S., Yonezawa, M., O’Sullivan, R. J., Sengupta, R., Perez-Burgos, L., Opravil, S., Mechtler, K., Schotta, G., & Jenuwein, T. (2006) · Genes & Development · doi:10.1101/gad.388206 · Cited by 376 · see citing works

H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability

Peng, J. C., & Karpen, G. H. (2007) · Nature Cell Biology · doi:10.1038/ncb1514 · Cited by 375 · see citing works

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

Caridi, C. P., D’Agostino, C., Ryu, T., Zapotoczny, G., Delabaere, L., Li, X., Khodaverdian, V. Y., Amaral, N., Lin, E., Rau, A. R., et al. (2018) · Nature · doi:10.1038/s41586-018-0242-8 · Cited by 372 · see citing works

Suv39h-Dependent H3K9me3 Marks Intact Retrotransposons and Silences LINE Elements in Mouse Embryonic Stem Cells

Bulut-Karslioglu, A., De La Rosa-Velázquez, I. A., Ramirez, F., Barenboim, M., Onishi-Seebacher, M., Arand, J., Galán, C., Winter, G. E., Engist, B., Gerle, B., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.029 · Cited by 368 · see citing works

How ageing processes influence cancer

de Magalhães, J. P. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3497 · Cited by 367 · see citing works

Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases

Taddei, A., Maison, C., Roche, D., & Almouzni, G. (2001) · Nature Cell Biology · doi:10.1038/35055010 · Cited by 361 · see citing works

Differential DNA mismatch repair underlies mutation rate variation across the human genome

Supek, F., & Lehner, B. (2015) · Nature · doi:10.1038/nature14173 · Cited by 355 · see citing works

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

Stephens, A. D., Liu, P. Z., Banigan, E. J., Almassalha, L. M., Backman, V., Adam, S. A., Goldman, R. D., & Marko, J. F. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-06-0410 · Cited by 350 · see citing works

Histone H3 variants specify modes of chromatin assembly

Ahmad, K., & Henikoff, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172403699 · Cited by 333 · see citing works

A Strand-Specific Burst in Transcription of Pericentric Satellites Is Required for Chromocenter Formation and Early Mouse Development

Probst, A. V., Okamoto, I., Casanova, M., Marjou, F. E., Baccon, P. L., & Almouzni, G. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.002 · Cited by 323 · see citing works

Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells

Minc, E., Allory, Y., Worman, H. J., Courvalin, J., & Buendia, B. (1999) · Chromosoma · doi:10.1007/s004120050372 · Cited by 322 · see citing works

The Nucleation and Maintenance of Heterochromatin by a Histone Deacetylase in Fission Yeast

Yamada, T., Fischle, W., Sugiyama, T., Allis, C. D., & Grewal, S. I. S. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.002 · Cited by 313 · see citing works

Isolation and Characterization of Suv39h2 , a Second Histone H3 Methyltransferase Gene That Displays Testis-Specific Expression

O’Carroll, D., Scherthan, H., Peters, A. H. F. M., Opravil, S., Haynes, A. R., Laible, G., Rea, S., Schmid, M., Lebersorger, A., Jerratsch, M., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.24.9423-9433.2000 · Cited by 304 · see citing works

The Chromodomain Protein Swi6: A Key Component at Fission Yeast Centromeres

Ekwall, K., Javerzat, J., Lorentz, A., Schmidt, H., Cranston, G., & Allshire, R. C. (1995) · Science · doi:10.1126/science.7660126 · Cited by 299 · see citing works

Phosphatases: providing safe passage through mitotic exit

Wurzenberger, C., & Gerlich, D. W. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3149 · Cited by 293 · see citing works

Marked for death: Targeting epigenetic changes in cancer

Pfister, S. X., & Ashworth, A. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.256 · Cited by 288 · see citing works

Impact of transposable elements on polyploid plant genomes

Vicient, C. M., & Casacuberta, J. (2017) · Annals of Botany · doi:10.1093/aob/mcx078 · Cited by 288 · see citing works

Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure

Guler, G. D., Tindell, C. A., Pitti, R., Wilson, C., Nichols, K., KaiWai Cheung, T., Kim, H.-J., Wongchenko, M., Yan, Y., Haley, B., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.002 · Cited by 277 · see citing works

Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres

Folco, H. D., Pidoux, A. L., Urano, T., & Allshire, R. C. (2008) · Science · doi:10.1126/science.1150944 · Cited by 275 · see citing works

Extensive somatic L1 retrotransposition in colorectal tumorsPreprint

Sólyom, S., Ewing, A. D., Rahrmann, E. P., Doucet-O’Hare, T. T., Nelson, H. H., Burns, M. B., Harris, R. S., Sigmon, D. F., Casella, A. M., Avigdor, B. E., et al. (2012) · Genome Research · doi:10.1101/gr.145235.112 · Cited by 273 · see citing works

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

Iwase, S., Xiang, B., Ghosh, S., Ren, T., Lewis, P. W., Cochrane, J. C., Allis, C. D., Picketts, D. J., Patel, D. J., Li, H., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2062 · Cited by 272 · see citing works

Semi-conservative DNA replication through telomeres requires Taz1

Miller, K. M., Rog, O., & Cooper, J. P. (2006) · Nature · doi:10.1038/nature04638 · Cited by 268 · see citing works

Late DNA Synthesis in Heterochromatin

Lima-de-Faria, A., & Jaworska, H. (1968) · Nature · doi:10.1038/217138a0 · Cited by 267 · see citing works

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

Tsouroula, K., Furst, A., Rogier, M., Heyer, V., Maglott, A., Ferrand, A., Reina‐San‐Martin, B., & Soutoglou, E. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.06.002 · Cited by 250 · see citing works

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

Ryu, T., Spatola, B. N., Delabaere, L., Bowlin, K., Hopp, H., Kunitake, R. C., Karpen, G. H., & Chiolo, I. (2015) · Nature Cell Biology · doi:10.1038/ncb3258 · Cited by 248 · see citing works

The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1

Assland, R., & stewart, F. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.16.3168 · Cited by 245 · see citing works

RNA Interference Guides Histone Modification during the S Phase of Chromosomal Replication

Kloc, A., Zaratiegui, M., Nora, E. P., & Martienssen, R. A. (2008) · Current Biology · doi:10.1016/j.cub.2008.03.016 · Cited by 242 · see citing works

Mutations in the fission yeast silencing factors clr4 + and rik1 + disrupt the localisation of the chromo domain protein Swi6p and impair centromere function

Ekwall, K., Nimmo, E. R., Javerzat, J., Borgstrøm, B., Egel, R., Cranston, G., & Allshire, R. C. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.11.2637 · Cited by 241 · see citing works

Common themes and cell type specific variations of higher order chromatin arrangements in the mouse

Mayer, R., Brero, A., Hase, J. V., Schroeder, T., Cremer, T. J., & Dietzel, S. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-44 · Cited by 234 · see citing works

Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation

Saksouk, N., Barth, T. K., Ziegler-Birling, C., Olova, N. N., Nowak, A. J., Rey, E., Langerak, J. M., Urbach, S., Reik, W., Torres‐Padilla, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.10.001 · Cited by 231 · see citing works

Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia

Cuellar, T. L., Herzner, A., Zhang, X., Goyal, Y., Watanabe, C. K., Friedman, B. A., Janakiraman, V., Durinck, S., Stinson, J., Arnott, D. P., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201612160 · Cited by 229 · see citing works

Accumulation of small murine minor satellite transcripts leads to impaired centromeric architecture and function

Bouzinba-Ségard, H., Guais, A., & Francastel, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508006103 · Cited by 229 · see citing works

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin

Eustermann, S., Yang, J., Law, M. J., Amos, R., Chapman, L., Jelinska, C., Garrick, D., Clynes, D., Gibbons, R. J., Rhodes, D., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2070 · Cited by 223 · see citing works

Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency

Sridharan, R., Gonzales-Cope, M., Chronis, C., Bonora, G., McKee, R., Huang, C., Patel, S., Lopez, D., Mishra, N., Pellegrini, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2768 · Cited by 220 · see citing works

HP1 Proteins Form Distinct Complexes and Mediate Heterochromatic Gene Silencing by Nonoverlapping Mechanisms

Motamedi, M. R., Hong, E.-J. E., Li, X., Gerber, S. A., Denison, C., Gygi, S. P., & Moazed, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.026 · Cited by 218 · see citing works

INCENP Centromere and Spindle Targeting: Identification of Essential Conserved Motifs and Involvement of Heterochromatin Protein HP1

Ainsztein, A. M., Kandels-Lewis, S. E., Mackay, A. M., & Earnshaw, W. C. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.7.1763 · Cited by 215 · see citing works

KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors

Black, J. C., Manning, A. L., Rechem, C. V., Kim, J., Ladd, B., Cho, J., Pineda, C. M., Murphy, N., Daniels, D. L., Montagna, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.051 · Cited by 214 · see citing works

Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors

Timp, W., Bravo, H. C., McDonald, O. G., Goggins, M., Umbricht, C. B., Zeiger, M. A., Feinberg, A. P., & Irizarry, R. A. (2014) · Genome Medicine · doi:10.1186/s13073-014-0061-y · Cited by 204 · see citing works

Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability

Zeller, P., Padeken, J., van Schendel, R., Kalck, V., Tijsterman, M., & Gasser, S. M. (2016) · Nature Genetics · doi:10.1038/ng.3672 · Cited by 204 · see citing works

HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

Baldeyron, C., Soria, G., Roche, D., Cook, A. J. L., & Almouzni, G. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201101030 · Cited by 200 · see citing works

Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution

Hu, J., Lieb, J. D., Sancar, A., & Adar, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614430113 · Cited by 198 · see citing works

Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis

Adar, S., Hu, J., Lieb, J. D., & Sancar, A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603388113 · Cited by 193 · see citing works

Heterochromatin links to centromeric protection by recruiting shugoshin

Yamagishi, Y., Sakuno, T., Shimura, M., & Watanabe, Y. (2008) · Nature · doi:10.1038/nature07217 · Cited by 187 · see citing works

Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation

Peng, J. C., & Karpen, G. H. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000435 · Cited by 183 · see citing works

In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation

Verschure, P. J., van der Kraan, I., de Leeuw, W., van der Vlag, J., Carpenter, A. E., Belmont, A. S., & van Driel, R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.11.4552-4564.2005 · Cited by 183 · see citing works

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation

Camacho, O. V., Galan, C., Świst-Rosowska, K. M., Ching, R. W., Gamalinda, M., Karabiber, F., Rosa-Velázquez, I. A. D. L., Engist, B., Koschorz, B., Shukeir, N., et al. (2017) · eLife · doi:10.7554/elife.25293 · Cited by 182 · see citing works

A transcription factor–based mechanism for mouse heterochromatin formation

Bulut-Karslıoğlu, A., Perrera, V., Scaranaro, M., Rosa-Velázquez, I. A. D. L., van de Nobelen, S., Shukeir, N., Popow, J., Mifsud, B., Opravil, S., Pagani, M., et al. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2382 · Cited by 180 · see citing works

Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells

Garcia-Perez, J. L., Morell, M. H., Scheys, J. O., Kulpa, D. A., Morell, S., Carter, C. C., Hammer, G. D., Collins, K. L., O’Shea, K. S., Menéndez, P. R., et al. (2010) · Nature · doi:10.1038/nature09209 · Cited by 175 · see citing works

A CAF‐1 dependent pool of HP1 during heterochromatin duplication

Quivy, J., Roche, D. M. J., Kirschner, D. B., Tagami, H., Nakatani, Y., & Almouzni, G. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600362 · Cited by 174 · see citing works

RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin

Johnson, W. L., Yewdell, W. T., Bell, J. C., McNulty, S. M., Duda, Z., O'Neill, R. J. W., Sullivan, B. A., & Straight, A. F. (2017) · eLife · doi:10.7554/elife.25299 · Cited by 162 · see citing works

Human heterochromatin proteins form large domains containing KRAB-ZNF genesPreprint

Vogel, M. J., Guelen, L., de Wit, E., Peric‐Hupkes, D., Lodén, M., Talhout, W., Feenstra, M., Abbas, B., Classen, A.-K., & van Steensel, B. (2006) · Genome Research · doi:10.1101/gr.5391806 · Cited by 150 · see citing works

A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly

Canzio, D., Liao, M., Naber, N. I., Pate, E., Larson, A. G., Wu, S., Marina, D. B., Garcia, J. F., Madhani, H. D., Cooke, R., et al. (2013) · Nature · doi:10.1038/nature12032 · Cited by 149 · see citing works

The HP1–p150/CAF-1 interaction is required for pericentric heterochromatin replication and S-phase progression in mouse cells

Quivy, J.-P., Gérard, A., Cook, A. J. L., Roche, D., & Almouzni, G. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1470 · Cited by 148 · see citing works

Proliferation-dependent and cell cycle–regulated transcription of mouse pericentric heterochromatin

Lu, J., & Gilbert, D. M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706176 · Cited by 145 · see citing works

Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast

Fischer, T., Cui, B., Dhakshnamoorthy, J., Zhou, M., Rubin, C., Zofall, M., Veenstra, T. D., & Grewal, S. I. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813063106 · Cited by 142 · see citing works

HP1 Binding to Chromatin Methylated at H3K9 Is Enhanced by Auxiliary Factors

Eskeland, R., Eberharter, A., & Imhof, A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01576-06 · Cited by 136 · see citing works

Linking Heterochromatin Protein 1 (HP1) to cancer progression

Dialynas, G. K., Vitalini, M. W., & Wallrath, L. L. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.09.007 · Cited by 131 · see citing works

Effects of tethering HP1 to euchromatic regions of the Drosophila genome

Li, Y., Danzer, J. R., Alvarez, P., Belmont, A. S., & Wallrath, L. L. (2003) · Development · doi:10.1242/dev.00405 · Cited by 129 · see citing works

DNA replication timing and selection shape the landscape of nucleotide variation in cancer genomes

Woo, Y., & Li, W. (2012) · Nature Communications · doi:10.1038/ncomms1982 · Cited by 127 · see citing works

The Emerging Role of HP1 in the DNA Damage Response

Dinant, C., & Luijsterburg, M. S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01048-09 · Cited by 122 · see citing works

The secret message of heterochromatin: new insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription.

Eymery, A., Callanan, M., & Vourc'h, C. (2009) · International Journal of Developmental Biology · doi:10.1387/ijdb.082673ae · Cited by 120 · see citing works

The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading inDrosophila

Zhang, W., Deng, H., Bao, X., Lerach, S., Girton, J. R., Johansen, J., & Johansen, K. M. (2005) · Development · doi:10.1242/dev.02199 · Cited by 117 · see citing works

Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair

Nair, N., Shoaib, M., & Sørensen, C. S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071486 · Cited by 110 · see citing works

Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability

Slee, R. B., Steiner, C. M., Herbert, B.-S., Vance, G. H., Hickey, R. J., Schwarz, T., Christan, S., Radovich, M., Schneider, B. P., Schindelhauer, D., et al. (2011) · Oncogene · doi:10.1038/onc.2011.502 · Cited by 110 · see citing works

Transcription Restores DNA Repair to Heterochromatin, Determining Regional Mutation Rates in Cancer Genomes

ZHENG, C. L., Wang, N. J., Chung, J., Moslehi, H., Sanborn, Z., Hur, J., Collisson, E. A., Vemula, S. S., Naujokas, A., Chiotti, K., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.031 · Cited by 109 · see citing works

A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatinPreprint

Janssen, A., Breuer, G. A., Brinkman, E. K., van der Meulen, A. I., Borden, S. V., van Steensel, B., Bindra, R. S., LaRocque, J. R., & Karpen, G. H. (2016) · Genes & Development · doi:10.1101/gad.283028.116 · Cited by 109 · see citing works

The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells

Kim, T., Shin, S., Berry, W. L., Oh, S., & Janknecht, R. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24009 · Cited by 108 · see citing works

Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

Wu, W., Nishikawa, H., Fukuda, T., Vittal, V., Asano, M., Miyoshi, Y., Klevit, R. E., & Ohta, T. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2796 · Cited by 104 · see citing works

Repeat DNA in genome organization and stability

Padeken, J., Zeller, P. J., & Gasser, S. M. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.03.009 · Cited by 102 · see citing works

Genetic instability: tipping the balance

Janssen, A., & Medema, R. H. (2012) · Oncogene · doi:10.1038/onc.2012.576 · Cited by 97 · see citing works

The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin

Trewick, S. C., Minc, E., Antonelli, R., Urano, T., & Allshire, R. C. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601892 · Cited by 95 · see citing works

Common fragile sites are characterized by histone hypoacetylation

Jiang, Y., Lucas, I., Young, D. J., Davis, E. M., Karrison, T. G., Rest, J. S., & Beau, M. M. L. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp410 · Cited by 94 · see citing works

M32, a murine homologue of Drosophila heterochromatin protein 1 (HP1), localises to euchromatin within interphase nuclei and is largely excluded from constitutive heterochromatin

Horsley, D., Hutchings, A., Butcher, G. W., & Singh, P. B. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134363 · Cited by 90 · see citing works

The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryos

Eymery, A., Liu, Z., Ozonov, E. A., Stadler, M. B., & Peters, A. H. F. M. (2016) · Development · doi:10.1242/dev.132746 · Cited by 88 · see citing works

Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly

Shirai, A., Kawaguchi, T., Shimojo, H., Muramatsu, D., Ishida-Yonetani, M., Nishimura, Y., Kimurâ, H., Nakayama, J., & Shinkai, Y. (2017) · eLife · doi:10.7554/elife.25317 · Cited by 88 · see citing works

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells

Kang, J., Chaudhary, J., Dong, H., Kim, S., Brautigam, C. A., & Yu, H. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-01-0009 · Cited by 88 · see citing works

Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis

García-Nieto, P. E., Schwartz, E. K., King, D. A., Paulsen, J., Collas, P., Herrera, R. E., & Morrison, A. J. (2017) · The EMBO Journal · doi:10.15252/embj.201796717 · Cited by 85 · see citing works

Heterochromatin protein 1α: a hallmark of cell proliferation relevant to clinical oncology

de Koning, L., Savignoni, A., Boumendil, C., Rehman, H., Asselain, B. J. R., Sastre‐Garau, X., & Almouzni, G. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900022 · Cited by 80 · see citing works

Completing the human genome: the progress and challenge of satellite DNA assembly

Miga, K. H. (2015) · Chromosome Research · doi:10.1007/s10577-015-9488-2 · Cited by 80 · see citing works

In Vivo Dynamics of Swi6 in Yeast: Evidence for a Stochastic Model of Heterochromatin

Cheutin, T., Gorski, S. A., May, K., Singh, P. B., & Misteli, T. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3157-3167.2004 · Cited by 79 · see citing works

Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer

Rondinelli, B., Rosano, D., Antonini, E., Frenquelli, M., Montanini, L., Huang, D., Segalla, S., Yoshihara, K., Amin, S. B., Lazarević, D., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81040 · Cited by 78 · see citing works

CHROMOSOME CONSTITUTION AND BEHAVIOR IN EVERSPORTING AND MOTTLING IN DROSOPHILA MELANOGASTER

Gowen, J. W., & Gay, E. H. (1934) · Genetics · doi:10.1093/genetics/19.3.189 · Cited by 76 · see citing works

H3K56me3 Is a Novel, Conserved Heterochromatic Mark That Largely but Not Completely Overlaps with H3K9me3 in Both Regulation and Localization

Jack, A. P. M., Bussemer, S., Hahn, M., Pünzeler, S., Snyder, M., Wells, M. B., Csankovszki, G., Solovei, I. V., Schotta, G., & Hake, S. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0051765 · Cited by 73 · see citing works

Wip1 Controls Global Heterochromatin Silencing via ATM/BRCA1-Dependent DNA Methylation

Filipponi, D., Müller, J., Emelyanov, A., & Bulavin, D. V. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.08.022 · Cited by 67 · see citing works

HP1-Assisted Aurora B Kinase Activity Prevents Chromosome Segregation Errors

Abe, Y., Sako, K., Takagaki, K., Hirayama, Y., Uchida, K. S. K., Herman, J., DeLuca, J. G., & Hirota, T. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.02.008 · Cited by 66 · see citing works

RNA interference is essential for cellular quiescence

Roche, B., Arcangioli, B., & Martienssen, R. A. (2016) · Science · doi:10.1126/science.aah5651 · Cited by 66 · see citing works

Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis

Papazyan, R., Voronina, E., Chapman, J. R., Luperchio, T. R., Gilbert, T. M., Meier, E. L., Mackintosh, S. G., Shabanowitz, J., Tackett, A. J., Reddy, K. L., et al. (2014) · eLife · doi:10.7554/elife.02996 · Cited by 66 · see citing works

The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic

Swenson, J. M., Colmenares, S. U., Strom, A. R., Costes, S. V., & Karpen, G. H. (2016) · eLife · doi:10.7554/elife.16096 · Cited by 65 · see citing works

Differential contribution of HP1 proteins to DNA end resection and homology-directed repair

Soria, G., & Almouzni, G. (2013) · Cell Cycle · doi:10.4161/cc.23215 · Cited by 63 · see citing works

Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast

Alper, B. J., Job, G., Yadav, R. K., Shanker, S., Lowe, B. R., & Partridge, J. F. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.143 · Cited by 62 · see citing works

Major role for a 3p21 region and lack of involvement of the t(3;8) breakpoint region in the development of renal cell carcinoma suggested by loss of heterozygosity analysis

van den Berg, A., Hulsbeek, M. M. F., de Jong, D., Kok, K., Veldhuis, P. M. J. F., Roche, J., & Buys, C. H. C. M. (1996) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199601)15:1 · Cited by 59 · see citing works

Drosophila Histone Demethylase KDM4A Has Enzymatic and Non-enzymatic Roles in Controlling Heterochromatin Integrity

Colmenares, S. U., Swenson, J. M., Langley, S. A., Kennedy, C., Costes, S. V., & Karpen, G. H. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.06.014 · Cited by 50 · see citing works

Deacetylation of H4-K16Ac and heterochromatin assembly in senescence

Contrepois, K., Thuret, J., Courbeyrette, R., Fenaille, F., & Mann, C. (2012) · Epigenetics & Chromatin · doi:10.1186/1756-8935-5-15 · Cited by 49 · see citing works

Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs

Joh, R. I., Khanduja, J. S., Calvo, I. A., Mistry, M., Palmieri, C. M., Savol, A. J., Sui, S. J. H., Sadreyev, R. I., Aryee, M. J., & Motamedi, M. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.11.020 · Cited by 48 · see citing works

And yet, it moves: nuclear and chromatin dynamics of a heterochromatic double-strand break

Caridi, P. C., Delabaere, L., Zapotoczny, G., & Chiolo, I. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0291 · Cited by 47 · see citing works

Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells

Oka, Y., Suzuki, K., Yamauchi, M., Mitsutake, N., & Yamashita, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.07.021 · Cited by 44 · see citing works

Sgo1 establishes the centromeric cohesion protection mechanism in G2 before subsequent Bub1-dependent recruitment in mitosis

Perera, D., & Taylor, S. S. (2010) · Journal of Cell Science · doi:10.1242/jcs.059501 · Cited by 42 · see citing works

Dissecting the role of H3K64me3 in mouse pericentromeric heterochromatin

Lange, U. C., Siebert, S., Wossidlo, M., Weiss, T., Ziegler-Birling, C., Walter, J., Torres‐Padilla, M., Daujat, S., & Schneider, R. (2013) · Nature Communications · doi:10.1038/ncomms3233 · Cited by 37 · see citing works

Epigenetic Inheritance and Reprogramming in Plants and Fission YeastPreprint

Martienssen, R. A., Kloc, A., Slotkin, R. K., & Tanurdžić, M. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.062 · Cited by 36 · see citing works

Dynamics of Setdb1 expression in early mouse development

Cho, S., Park, J. S., Kwon, S., & Kang, Y. (2012) · Gene Expression Patterns · doi:10.1016/j.gep.2012.03.005 · Cited by 32 · see citing works

DNA mismatch repair efficiency and fidelity are elevated during DNA synthesis in human cells

Edelbrock, M. A., Kaliyaperumal, S., & Williams, K. J. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.12.006 · Cited by 26 · see citing works

Centromere cleavage is a mechanism underlying isochromosome formation in skin and head and neck carcinomas

Jin, Y., Jin, C., Salemark, L., Martins, C., Wennerberg, J., & Mertens, F. (2000) · Chromosoma · doi:10.1007/s004120000107 · Cited by 25 · see citing works

Regulatory dissection of the CBX5 and hnRNPA1 bi-directional promoter in human breast cancer cells reveals novel transcript variants differentially associated with HP1α down-regulation in metastatic cells

Vad‐Nielsen, J., Jakobsen, K. R., Daugaard, T. F., Thomsen, R., Brügmann, A. H., Sørensen, B. S., & Nielsen, A. L. (2016) · BMC Cancer · doi:10.1186/s12885-016-2059-x · Cited by 18 · see citing works

Variability in Chromatin Architecture and Associated DNA Repair at Genomic Positions Containing Somatic Mutations

Lim, B., Mun, J., Kim, S., & Kim, S. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3033 · Cited by 15 · see citing works

A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference

Cramer, D., Serrano, L. G., & Schaefer, M. H. (2016) · eLife · doi:10.7554/elife.16519 · Cited by 9 · see citing works

Liquid–liquid phase separation in human health and diseases

Wang, B., Zhang, L., Dai, T., Qin, Z., Lu, H., Zhang, L., & Zhou, F. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00678-1 · Cited by 741 · see citing works

Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes

Roach, R. J., Garavís, M., González, C., Jameson, G. B., Filichev, V. V., & Hale, T. K. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1138 · Cited by 520 · see citing works

Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism

Wang, L., Gao, Y., Zheng, X., Liu, C., Dong, S., Li, R., Zhang, G., Wei, Y., Qu, H., Li, Y., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.08.019 · Cited by 372 · see citing works

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

Zhang, H., Ji, X., Li, P., Liu, C., Lou, J., Wang, Z., Wen, W., Xiao, Y., Zhang, M., & Zhu, X. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1702-x · Cited by 350 · see citing works

The relationship between genome structure and function

Oudelaar, A. M., & Higgs, D. R. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-020-00303-x · Cited by 304 · see citing works

Role of H3K9me3 heterochromatin in cell identity establishment and maintenance

Nicetto, D., & Zaret, K. S. (2019) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2019.04.013 · Cited by 312 · see citing works

Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation

Kan, R. L., Chen, J., & Sallam, T. (2022) · Trends in Genetics · doi:10.1016/j.tig.2021.06.014 · Cited by 308 · see citing works

Epigenetic patterns in a complete human genome

Gershman, A., Sauria, M. E. G., Guitart, X., Vollger, M. R., Hook, P. W., Hoyt, S. J., Jain, M., Shumate, A., Razaghi, R., Koren, S., et al. (2022) · Science · doi:10.1126/science.abj5089 · Cited by 297 · see citing works

On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability

Khristich, A. N., & Mirkin, S. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007678 · Cited by 289 · see citing works

Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin

Montgomery, S. A., Tanizawa, Y., Gálik, B., Wang, N., Ito, T., Mochizuki, T., Akimcheva, S., Bowman, J. L., Cognat, V., Maréchal‐Drouard, L., et al. (2020) · Current Biology · doi:10.1016/j.cub.2019.12.015 · Cited by 247 · see citing works

Transcription-mediated replication hindrance: a major driver of genome instabilityPreprint

Gómez‐González, B., & Aguilera, A. (2019) · Genes & Development · doi:10.1101/gad.324517.119 · Cited by 224 · see citing works

The molecular basis of heterochromatin assembly and epigenetic inheritance

Grewal, S. I. S. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.04.020 · Cited by 210 · see citing works

Endogenous Retroelements and the Viral Mimicry Response in Cancer Therapy and Cellular Homeostasis

Chen, R. E., Ishak, C. A., & Carvalho, D. D. D. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0506 · Cited by 206 · see citing works

MeCP2 links heterochromatin condensates and neurodevelopmental disease

Li, C. H., Coffey, E. L., Dall’Agnese, A., Hannett, N. M., Tang, X., Henninger, J. E., Platt, J. M., Oksuz, O., Zamudio, A. V., Afeyan, L. K., et al. (2020) · Nature · doi:10.1038/s41586-020-2574-4 · Cited by 197 · see citing works

Anticancer Therapy with HDAC Inhibitors: Mechanism-Based Combination Strategies and Future Perspectives

Jenke, R., Reßing, N., Hansen, F. K., Aigner, A. M., & Büch, T. (2021) · Cancers · doi:10.3390/cancers13040634 · Cited by 194 · see citing works

The control of gene expression and cell identity by H3K9 trimethylation

Ninova, M., Tóth, K. F., & Aravin, A. A. (2019) · Development · doi:10.1242/dev.181180 · Cited by 162 · see citing works

Losing DNA methylation at repetitive elements and breaking bad

Pappalardo, X. G., & Barra, V. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-021-00400-z · Cited by 153 · see citing works

Taming transposable elements in vertebrates: from epigenetic silencing to domestication

Almeida, M. V., Vernaz, G., Putman, A. L. K., & Miska, E. A. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.02.009 · Cited by 145 · see citing works

Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

Vilarrasa‐Blasi, R., Soler-Vila, P., Verdaguer-Dot, N., Russiñol, N., Stefano, M. D., Chapaprieta, V., Clot, G., Farabella, I., Cuscó, P., Kulis, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20849-y · Cited by 146 · see citing works

Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers

Spracklin, G., Abdennur, N. A., Imakaev, M., Chowdhury, N., Pradhan, S., Mirny, L. A., & Dekker, J. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00892-7 · Cited by 139 · see citing works

Liquid–Liquid Phase Separation in ChromatinPreprint

Rippe, K. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040683 · Cited by 140 · see citing works

Paradoxical association of TET loss of function with genome-wide DNA hypomethylation

López-Moyado, I. F., Tsagaratou, A., Yuita, H., Seo, H., Delatte, B., Heinz, S., Benner, C. W., & Rao, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903059116 · Cited by 125 · see citing works

Double-edged sword: The evolutionary consequences of the epigenetic silencing of transposable elements

Choi, J. Y., & Lee, Y. C. G. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008872 · Cited by 127 · see citing works

Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex- and age-related functional regulation

Lu, R. J., Taylor, S., Contrepois, K., Kim, M., Bravo, J. I., Ellenberger, M., Sampathkumar, N. K., & Benayoun, B. A. (2021) · Nature Aging · doi:10.1038/s43587-021-00086-8 · Cited by 128 · see citing works

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

Xu, J., Ma, H., Ma, H., Jiang, W., Mela, C. A., Duan, M.-H., Zhao, S., Gao, C., Hahm, E., Lardo, S. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15718-7 · Cited by 120 · see citing works

Single-cell nuclear architecture across cell types in the mouse brain

Takei, Y., Zheng, S., Yun, J., Shah, S., Pierson, N. G., White, J. A., Schindler, S., Tischbirek, C. H., Yuan, G., & Cai, L. (2021) · Science · doi:10.1126/science.abj1966 · Cited by 111 · see citing works

Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases

Wu, Z., Qu, J., & Liu, G.-H. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00775-3 · Cited by 118 · see citing works

Transposable elements in mammalian chromatin organization

Lawson, H. A., Liang, Y., & Wang, T. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00609-6 · Cited by 121 · see citing works

TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer

López-Moyado, I. F., Ko, M., Hogan, P. G., & Rao, A. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-080223-044610 · Cited by 116 · see citing works

In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.

Rodríguez-Matellán, A., Alcazar, N., Hernández, F., Serrano, M., & Ávila, J. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.09.010 · Cited by 116 · see citing works

Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration

Liang, C., Liu, Z., Song, M., Li, W., Wu, Z., Wang, Z., Wang, Q., Wang, S., Yan, K., Sun, L., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0385-7 · Cited by 117 · see citing works

Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

Montavon, T., Shukeir, N., Erikson, G. A., Engist, B., Onishi‐Seebacher, M., Ryan, D. P., Musa, Y., Mittler, G., Meyer, A. G., Genoud, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24532-8 · Cited by 111 · see citing works

Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries

Bizhanova, A., & Kaufman, P. D. (2020) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2020.194666 · Cited by 107 · see citing works

Confined migration induces heterochromatin formation and alters chromatin accessibility

Hsia, C.-R., McAllister, J., Hasan, O., Judd, J., Lee, S. Y., Agrawal, R., Chang, C., Soloway, P. D., & Lammerding, J. (2022) · iScience · doi:10.1016/j.isci.2022.104978 · Cited by 106 · see citing works

53BP1 regulates heterochromatin through liquid phase separation

Zhang, L., Geng, X., Wang, F., Tang, J., Ichida, Y., Sharma, A., Jin, S., Chen, M., Tang, M., Pozo, F. M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28019-y · Cited by 104 · see citing works

Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains

Gopi, L. K., & Kidder, B. L. (2021) · Nature Communications · doi:10.1038/s41467-021-21707-1 · Cited by 95 · see citing works

Contributions of Histone Variants in Nucleosome Structure and Function

Kurumizaka, H., Kujirai, T., & Takizawa, Y. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.10.012 · Cited by 97 · see citing works

The American lobster genome reveals insights on longevity, neural, and immune adaptations

Polinski, J. M., Zimin, A. V., Clark, K. F., Kohn, A. B., Sadowski, N., Timp, W., Ptitsyn, A. A., Khanna, P., Romanova, D. Y., Williams, P., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe8290 · Cited by 90 · see citing works

Phase separation drives decision making in cell division

Liu, X., Liu, X., Wang, H., Dou, Z., Ruan, K., Hill, D. L., Li, L., Shi, Y., & Yao, X. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011746 · Cited by 89 · see citing works

Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in DrosophilaPreprint

Seller, C. A., Cho, C.-Y., & O’Farrell, P. H. (2019) · Genes & Development · doi:10.1101/gad.321646.118 · Cited by 88 · see citing works

Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus

Habig, M., Lorrain, C., Feurtey, A., Komluski, J., & Stukenbrock, E. H. (2021) · Nature Communications · doi:10.1038/s41467-021-26108-y · Cited by 85 · see citing works

Role of Polycomb in the control of transposable elements

Deleris, A., Berger, F., & Duharcourt, S. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.06.003 · Cited by 84 · see citing works

Phase separation of DNA: From past to present

King, J. T., & Shakya, A. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.01.033 · Cited by 77 · see citing works

Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding

Her, C., Phan, T. M., Jovic, N., Kapoor, U., Ackermann, B. E., Rizuan, A., Kim, Y. C., Mittal, J., & Debelouchina, G. T. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac1194 · Cited by 72 · see citing works

Transposable elements as new players in neurodegenerative diseases

Ravel‐Godreuil, C., Znaidi, R., Bonnifet, T., Joshi, R. L., & Fuchs, J. (2021) · FEBS Letters · doi:10.1002/1873-3468.14205 · Cited by 67 · see citing works

DNA methylation in disease: Immunodeficiency, Centromeric instability, Facial anomalies syndrome

Vukić, M., & Daxinger, L. (2019) · Essays in Biochemistry · doi:10.1042/ebc20190035 · Cited by 64 · see citing works

Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNA

Langley, S. A., Miga, K. H., Karpen, G. H., & Langley, C. H. (2019) · eLife · doi:10.7554/elife.42989 · Cited by 63 · see citing works

Physical Chemistry of Cellular Liquid‐Phase Separation

Bentley, E. P., Frey, B. B., & Deniz, A. A. (2018) · Chemistry - A European Journal · doi:10.1002/chem.201805093 · Cited by 66 · see citing works

Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?

Janic, A., Abad, E., & Amelio, I. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01259-9 · Cited by 66 · see citing works

Establishment and evolution of heterochromatin

Liu, J., Ali, M., & Zhou, Q. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14303 · Cited by 65 · see citing works

The Polycomb repressive complex 2 deposits H3K27me3 and represses transposable elements in a broad range of eukaryotes

Hisanaga, T., Romani, F., Wu, S., Kowar, T., Wu, Y., Lintermann, R., Fridrich, A., Cho, C. H., Chaumier, T., Jamge, B., et al. (2023) · Current Biology · doi:10.1016/j.cub.2023.08.073 · Cited by 60 · see citing works

Imaging the response to DNA damage in heterochromatin domains reveals core principles of heterochromatin maintenance

Fortuny, A., Chansard, A., Caron, P., Chevallier, O., Leroy, O., Renaud, O., & Polo, S. (2021) · Nature Communications · doi:10.1038/s41467-021-22575-5 · Cited by 48 · see citing works

Nuclear cGAS: guard or prisoner?

Mann, C. C. D. O., & Hopfner, K. (2021) · The EMBO Journal · doi:10.15252/embj.2021108293 · Cited by 65 · see citing works

Is euchromatin really open in the cell?

Maeshima, K., Iida, S., Shimazoe, M. A., Tamura, S., & Ide, S. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.05.007 · Cited by 65 · see citing works

Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells

Novo, C. L., Wong, E. V., Hockings, C., Poudel, C., Sheekey, E., Wiese, M., Okkenhaug, H., Boulton, S. J., Basu, S., Walker, S. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31198-3 · Cited by 61 · see citing works

Metabolic regulation by p53 prevents R-loop-associated genomic instability

Panatta, E., Butera, A., Mammarella, E., Pitolli, C., Mauriello, A., Leist, M., Knight, R. A., Melino, G., & Amelio, I. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111568 · Cited by 59 · see citing works

The SUMO Ligase Su(var)2-10 Controls Hetero- and Euchromatic Gene Expression via Establishing H3K9 Trimethylation and Negative Feedback Regulation

Ninova, M., Godneeva, B. K., Chen, Y.-C. A., Luo, Y., Prakash, S. J., Jankovics, F., Erdélyi, M., Aravin, A. A., & Tóth, K. F. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.033 · Cited by 61 · see citing works

Non-complementary strand commutation as a fundamental alternative for information processing by DNA and gene regulation

Nikitin, M. P. (2023) · Nature Chemistry · doi:10.1038/s41557-022-01111-y · Cited by 59 · see citing works

Transposable Elements as a Source of Novel Repetitive DNA in the Eukaryote Genome

Zattera, M. L., & Bruschi, D. P. (2022) · Cells · doi:10.3390/cells11213373 · Cited by 52 · see citing works

A unique chromatin profile defines adaptive genomic regions in a fungal plant pathogen

Cook, D. E., Kramer, H. M., Torres, D. E., Seidl, M. F., & Thomma, B. P. H. J. (2020) · eLife · doi:10.7554/elife.62208 · Cited by 50 · see citing works

Alzheimer’s disease and related tauopathies: disorders of disrupted neuronal identity

Frost, B. E. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.07.006 · Cited by 56 · see citing works

The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins

Saint‐Leandre, B., & Levine, M. T. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.01.007 · Cited by 51 · see citing works

Nematode chromosomes

Carlton, P. M., Davis, R. E., & Ahmed, S. C. (2022) · Genetics · doi:10.1093/genetics/iyac014 · Cited by 46 · see citing works

Multifunctional histone variants in genome function

Wong, L. H., & Tremethick, D. J. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00759-1 · Cited by 53 · see citing works

DNA sequence-dependent formation of heterochromatin nanodomains

Thorn, G. J., Clarkson, C. T., Rademacher, A., Mamayusupova, H., Schotta, G., Rippe, K., & Teif, V. B. (2022) · Nature Communications · doi:10.1038/s41467-022-29360-y · Cited by 49 · see citing works

Aberrant liquid-liquid phase separation and amyloid aggregation of proteins related to neurodegenerative diseases

Ahmad, A., Uversky, V. N., & Khan, R. H. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.132 · Cited by 52 · see citing works

Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin

Lee, Y. C. G., Ogiyama, Y., Martins, N. M. C., Beliveau, B. J., Acevedo, D., Wu, C.-T., Cavalli, G., & Karpen, G. H. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008673 · Cited by 47 · see citing works

Emerging Implications of Phase Separation in Cancer

Ren, J., Zhang, Z., Zong, Z., Zhang, L., & Zhou, F. (2022) · Advanced Science · doi:10.1002/advs.202202855 · Cited by 47 · see citing works

Diverse heterochromatin states restricting cell identity and reprogramming

McCarthy, R. L., Zhang, J., & Zaret, K. S. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.02.007 · Cited by 46 · see citing works

Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4APreprint

Janssen, A., Colmenares, S. U., Lee, T., & Karpen, G. H. (2018) · Genes & Development · doi:10.1101/gad.317537.118 · Cited by 47 · see citing works

Mechanical regulation of histone modifications and cell plasticity

Song, Y., Soto, J., & Li, S. (2020) · Current Opinion in Solid State and Materials Science · doi:10.1016/j.cossms.2020.100872 · Cited by 47 · see citing works

Heterochromatin-dependent transcription of satellite DNAs in the Drosophila melanogaster female germline

Wei, X., Eickbush, D. G., Speece, I., & Larracuente, A. M. (2021) · eLife · doi:10.7554/elife.62375 · Cited by 44 · see citing works

Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery

Andreev, V. I., Yu, C., Wang, J., Schnabl, J., Tirián, L., Gehre, M., Handler, D., Duchek, P., Novatchkova, M., Baumgartner, L., et al. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00721-x · Cited by 47 · see citing works

Emerging roles of telomeric chromatin alterations in cancer

Cacchione, S., Biroccio, A., & Rizzo, A. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1030-5 · Cited by 46 · see citing works

Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing

Osumi, K., Sato, K., Murano, K., Siomi, H., & Siomi, M. C. (2019) · EMBO Reports · doi:10.15252/embr.201948296 · Cited by 46 · see citing works

Role of Connexins 30, 36, and 43 in Brain Tumors, Neurodegenerative Diseases, and Neuroprotection

Sánchez, O. F., Rodríguez, A. V., Velasco-España, J. M., Murillo, L. C., Sutachan, J. J., & Albarracin, S.-L. (2020) · Cells · doi:10.3390/cells9040846 · Cited by 46 · see citing works

OUP accepted manuscript

Liang, C., Ke, Q., Liu, Z., Ren, J., Zhang, W., Hu, J., Wang, Z., Chen, H., Xia, K., Lai, X., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac146 · Cited by 49 · see citing works

The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders

Frost, B., & Dubnau, J. (2024) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-082823-020615 · Cited by 45 · see citing works

Euchromatin Activity Enhances Segregation and Compaction of Heterochromatin in the Cell Nucleus

Mahajan, A., Yan, W., Zidovska, A., Saintillan, D., & Shelley, M. (2022) · Physical Review X · doi:10.1103/physrevx.12.041033 · Cited by 44 · see citing works

Heterochromatin organization and phase separation

Zhang, H., Qin, W., Romero, H., Leonhardt, H., & Cardoso, M. C. (2023) · Nucleus · doi:10.1080/19491034.2022.2159142 · Cited by 45 · see citing works

The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks

Pereira, Q. C., dos Santos, T. W., Fortunato, I. M., & Ribeiro, M. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065508 · Cited by 49 · see citing works

Toward a Unified Theory of Aging and Regeneration

West, M. D., Sternberg, H., Labat, I., Janus, J., Chapman, K. B., Malik, N. N., de Grey, A. D., & Larocca, D. (2019) · Regenerative Medicine · doi:10.2217/rme-2019-0062 · Cited by 47 · see citing works

The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways

Chen, Z., & Tyler, J. K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.909696 · Cited by 42 · see citing works

Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review

Bui, T. A., Jickling, G. C., & Winship, I. R. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1041333 · Cited by 44 · see citing works

Targeting pericentric non-consecutive motifs for heterochromatin initiation

Ma, R., Zhang, Y., Zhang, J., Zhang, P., Liu, Z., Fan, Y., Wang, H., Zhang, Z., & Zhu, B. (2024) · Nature · doi:10.1038/s41586-024-07640-5 · Cited by 43 · see citing works

SUV39 SET domains mediate crosstalk of heterochromatic histone marks

Stirpe, A., Guidotti, N., Northall, S. J., Kilic, S., Hainard, A., Vadas, O., Fierz, B., & Schalch, T. (2021) · eLife · doi:10.7554/elife.62682 · Cited by 41 · see citing works

Karyotype variation, spontaneous genome rearrangements affecting chemical insensitivity, and expression level polymorphisms in the plant pathogen Phytophthora infestans revealed using its first chromosome-scale assembly

Matson, M. E. H., Liang, Q., Lonardi, S., & Judelson, H. S. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010869 · Cited by 42 · see citing works

DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain

Zhang, J., Bellani, M., James, R., Pokharel, D., Zhang, Y.-Q., Reynolds, J., McNee, G. S., Jackson, A., Stewart, G., & Seidman, M. (2020) · Nature Communications · doi:10.1038/s41467-020-17449-1 · Cited by 39 · see citing works

The Stochastic Genome and Its Role in Gene ExpressionPreprint

Bohrer, C. H., & Larson, D. R. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040386 · Cited by 42 · see citing works

Histone H1 facilitates restoration of H3K27me3 during DNA replication by chromatin compaction

Liu, C., Yu, J., Song, A., Wang, M., Hu, J., Chen, P., Zhao, J., & Li, G. (2023) · Nature Communications · doi:10.1038/s41467-023-39846-y · Cited by 42 · see citing works

Genome-Protecting Compounds as Potential Geroprotectors

Proshkina, E., Shaposhnikov, M. V., & Moskalev, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124484 · Cited by 42 · see citing works

Hydrostatic pressure prevents chondrocyte differentiation through heterochromatin remodeling

Maki, K., Nava, M. M., Villeneuve, C., Chang, M., Furukawa, K. S., Ushida, T., & Wickström, S. A. (2020) · Journal of Cell Science · doi:10.1242/jcs.247643 · Cited by 38 · see citing works

TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells

Hong, T., Li, J., Guo, L., Cavalier, M., Wang, T., Dou, Y., de-la-Fuente, A. L. C., Fang, S., Guzman, A. G., Wohlan, K., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00505-y · Cited by 41 · see citing works

Transgenerational Self-Reconstruction of Disrupted Chromatin Organization After Exposure To An Environmental Stressor in Mice

Díaz-Castillo, C., Chamorro-García, R., Shioda, T., & Blumberg, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-49440-2 · Cited by 40 · see citing works

Epigenetics and genome stability

Feng, J. X., & Riddle, N. C. (2020) · Mammalian Genome · doi:10.1007/s00335-020-09836-2 · Cited by 42 · see citing works

The Force is Strong with This Epigenome: Chromatin Structure and Mechanobiology

Hsia, C.-R., Melters, D. P., & Dalal, Y. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168019 · Cited by 40 · see citing works

Linker histone H1 drives heterochromatin condensation via phase separation in Arabidopsis

He, S.-B., Yu, Y., Wang, L., Zhang, J., Bai, Z.-Y., Li, G.-H., Li, P.-L., & Feng, X.-Q. (2024) · The Plant Cell · doi:10.1093/plcell/koae034 · Cited by 33 · see citing works

The impact of epigenetic information on genome evolution

Yi, S. V., & Goodisman, M. A. D. (2021) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2020.0114 · Cited by 39 · see citing works

Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complexPreprint

Schnabl, J., Wang, J., Hohmann, U., Gehre, M., Batki, J., Andreev, V. I., Purkhauser, K., Fasching, N., Duchek, P., Novatchkova, M., et al. (2021) · Genes & Development · doi:10.1101/gad.347989.120 · Cited by 39 · see citing works

DDM1-mediated R-loop resolution and H2A.Z exclusion facilitates heterochromatin formation in Arabidopsis

Zhou, J., Lei, X., Shafiq, S., Zhang, W., Li, Q., Li, K., Zhu, J., Dong, Z., He, X., & Sun, Q. (2023) · Science Advances · doi:10.1126/sciadv.adg2699 · Cited by 38 · see citing works

Heterochromatin: A Critical Part of the Genome

Wallrath, L. L., Vitalini, M. W., & Elgin, S. C. R. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8624-4_13 · Cited by 6 · see citing works

Epigenetic regulation of heterochromatic DNA stability

Peng, J. C., & Karpen, G. H. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.01.021 · Cited by 209 · see citing works

L’hétérochromatine constitutive dans tous ses états

Terranova, R. (2008) · médecine/sciences · doi:10.1051/medsci/20082489720 · Cited by 5 · see citing works

Heterochromatin and Euchromatin-Organization, Boundaries, and Gene Regulation

Strålfors, A., & Ekwall, K. (2011) · Encyclopedia of Molecular Cell Biology and Molecular Medicine · doi:10.1002/3527600906.mcb.200400018.pub2 · Cited by 8 · see citing works

Drosophila heterochromatin: structure and function

Mteirek, R., Gueguen, N., Jensen, S., Brasset, É., & Vaury, C. (2014) · Current Opinion in Insect Science · doi:10.1016/j.cois.2014.04.003 · Cited by 7 · see citing works