The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes
Open accessAbstract
Noncoding RNAs are important components of regulatory networks controlling the epigenetic state of chromatin. We analyzed the role of pRNA (promoter-associated RNA), a noncoding RNA that is complementary to the rDNA promoter, in mediating de novo CpG methylation of rRNA genes (rDNA). We show that pRNA interacts with the target site of the transcription factor TTF-I, forming a DNA:RNA triplex that is specifically recognized by the DNA methyltransferase DNMT3b. The results reveal a compelling new mechanism of RNA-dependent DNA methylation, suggesting that recruitment of DNMT3b by DNA:RNA triplexes may be a common and generally used pathway in epigenetic regulation.
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Cites
Santoro, R., Li, J., & Grummt, I. (2002) · Nature Genetics · doi:10.1038/ng1010 · Cited by 406
Self-citationZhou, Y., Santoro, R., & Grummt, I. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf460 · Cited by 234 · cited 1×
“NoRC silences rRNA genes by recruiting enzymes that mediate heterochromatin formation and silencing (Zhou et al. 2002; Zhou and Grummt 2005).”
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Cited by
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Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Batista, P. J., & Chang, H. Y. (2013) · Cell · doi:10.1016/j.cell.2013.02.012 · Cited by 2,531
The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
Cech, T. R., & Steitz, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.008 · Cited by 2,524
Long noncoding RNAs: past, present, and future
Kung, J. T. Y., Colognori, D., & Lee, J. T. (2013) · Genetics · doi:10.1534/genetics.112.146704 · Cited by 1,874
Metadata
- Authors
- Schmitz, K.-M., Mayer, C., Postepska, A., & Grummt, I.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-10-15
- Volume
- 24
- Issue
- 20
- Pages
- 2264-2269
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2012589963
- Cited by
- 488
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Schmitz, K.-M., Mayer, C., Postepska, A., & Grummt, I. (2010). Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes. Genes & Development. https://doi.org/10.1101/gad.590910
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