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Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins
Open accessAbstract
The helix-loop-helix (HLH) protein Id lacks the basic DNA-binding domain common to this class of proteins. In vitro experiments suggested that Id could associate tightly with two other HLH proteins encoded by the E2A gene, E12 and E47 (referred to here collectively as E proteins) and prevent their binding to a sequence present in the muscle creatine kinase (MCK) enhancer either as homo-oligomers or hetero-oligomers with MyoD. In this report we present evidence for the in vivo roles of Id and E proteins: (1) Id and E proteins co-fractionate and co-immunoprecipitate in whole-cell extracts prepared from myoblasts; (2) the loss of Id protein observed during the conversion of proliferating myoblasts into mature myotubes correlates with the formation of MyoD/E hetero-oligomeric complexes in whole-cell extracts (these complexes do not form when purified Id protein is added to the extracts); and (3) stable overexpression of Id mRNA and protein in the C2C12 muscle cell line inhibits differentiation in these cells 16 hr post-induction. The myotubes that do eventually form 48 hr post-induction have no detectable Id protein in the nucleus despite the persistence of exogenous Id mRNA. These data support a model in which Id can inhibit muscle cell differentiation by associating with E proteins and preventing them from forming active hetero-oligomeric complexes with the muscle determination gene products.
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“When comparing Pax7+ cells in transcriptional cluster 4 with Pax7− cells in the same cluster, we found that Pax7+ cells showed significant upregulation of Id1, Id2 and Id3, which inhibit differentiation (Jen et al., 1992), and of the cell-cycle gene Ccnd1 (Fig. S3D).”
From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Jen et al., 1992
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Cites
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318
Smith, D. B., & Johnson, K. S. (1988) · Gene · doi:10.1016/0378-1119(88)90005-4 · Cited by 5,844
Expression of a single transfected cDNA converts fibroblasts to myoblasts
Davis, R. L., Weintraub, H. M., & Lassar, A. B. (1987) · Cell · doi:10.1016/0092-8674(87)90585-x · Cited by 3,388
Self-citationMurre, C., Page-McCaw, P., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,713
The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
Benezra, R., Davis, R. L., Lockshon, D., Turner, D. L., & Weintraub, H. M. (1990) · Cell · doi:10.1016/0092-8674(90)90214-y · Cited by 2,202
Self-citationMurre, C., Page-McCaw, P., Vaessin, H., Caudy, M. A., Jan, L. Y., Jan, Y. N., Cabrera, C. V., Buskin, J. N., Hauschka, S. D., Lassar, A. B., et al. (1989) · Cell · doi:10.1016/0092-8674(89)90434-0 · Cited by 1,815
Self-citationFavaloro, J. M., Treisman, R., & Kamen, R. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65070-8 · Cited by 1,292
Ron, D., & Habener, J. F. (1992) · Genes & Development · doi:10.1101/gad.6.3.439 · Cited by 1,156
Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.
Bader, D. M., Masaki, Τ., & Fischman, D. A. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.3.763 · Cited by 919
Blackwell, T. K., & Weintraub, H. M. (1990) · Science · doi:10.1126/science.2174572 · Cited by 912
Self-citation
Research works printed but not linked: 1
- Rosenthal, N. 1992. The myosin light chain ⅓ locus: A model for developmental control of skeletal muscle differentiation. In Gene expression in neuromuscular development (ed. H. Blau, T. Kelly, and B. Paterson). Raven Press, New York. (In press.)
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Cooper, C. L., Brady, G., Bilia, F., Iscove, N. N., & Quesenberry, P. J. (1997) · Blood · doi:10.1182/blood.v89.9.3155 · Cited by 52
Tiainen, M., Pajalunga, D., Ferrantelli, F., Soddu, S., Salvatori, G., Sacchi, A., & Crescenzi, M. (1996) · PubMed · Cited by 51
Morel, C., Cordier–Bussat, M., & Philippé, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.7.3046 · Cited by 51
RAZ, an Epstein-Barr virus transdominant repressor that modulates the viral reactivation mechanism
Furnari, F. B., Zacny, V. L., Quinlivan, E. B., Kenney, S. C., & Pagano, J. S. (1994) · Journal of Virology · doi:10.1128/jvi.68.3.1827-1836.1994 · Cited by 51
DNA-mediated Folding and Assembly of MyoD-E47 Heterodimers
Wendt, H., Thomas, R. M., & Ellenberger, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5735 · Cited by 50
Time course regulatory analysis based on paired expression and chromatin accessibility dataPreprint
Duren, Z., Chen, X. X., Xin, J., Wang, Y., & Wong, W. H. (2020) · Genome Research · doi:10.1101/gr.257063.119 · Cited by 50
Hong, S., Lee, J., Lee, J. B., Ji, J., & Bhatia, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.077511 · Cited by 49
Biederer, C. H., Ries, S. J., Moser, M., Florio, M., Israel, M. A., McCormick, F. P., & Buettner, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001430200 · Cited by 49
Peyton, M., Moss, L. G., & Tsai, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47336-x · Cited by 49
Structural organisation and chromosomal mapping of the human Id-3 gene
Deed, R. W., Hirose, T., Mitchell, E. L. D., Santibanez‐Koref, M., & Norton, J. D. (1994) · Gene · doi:10.1016/0378-1119(94)90676-9 · Cited by 48
Rutherford, M., & LeBrun, D. P. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65557-5 · Cited by 47
Differential Biological Activities of Mammalian Id Proteins in Muscle Cells
Melnikova, I. N., Bounpheng, M. A., Schatteman, G. C., Gilliam, D., & Christy, B. A. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4330 · Cited by 47
Kami, K., Noguchi, K., & Senba, E. (1995) · Cell and Tissue Research · doi:10.1007/bf00304506 · Cited by 47
Einarson, M. B., & Chao, M. V. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4175 · Cited by 47
Gundersen, K., Rabben, I., Klocke, B. J., & Merlie, J. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.7127 · Cited by 47
ID4: a new player in the cancer arena
Dell’Orso, S., Ganci, F., Strano, S., Blandino, G., & Fontemaggi, G. (2010) · Oncotarget · doi:10.18632/oncotarget.108 · Cited by 46
Id gene expression during development and molecular cloning of the human Id-1 gene
Zhu, W., Dahmen, J., Bulfone, A., Rigolet, M., Hernandez, M., Kuo, W.-L., Puelles, L., Rubenstein, J. L. R., & Israel, M. A. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00017-m · Cited by 46
Transcriptional control of globin gene switching during vertebrate development
Baron, M. H. (1997) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(96)00195-9 · Cited by 46
Chaudhary, J., Cupp, A. S., & Skinner, M. K. (1997) · Endocrinology · doi:10.1210/en.138.2.667 · Cited by 46
Expression of the helix‐loop‐helix gene Id3 during murine embryonic development
Ellmeier, W., & Weith, A. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030205 · Cited by 46
Ma, X., Wang, H., Ding, B., Zhong, H., Ghosh, S., & Lengyel, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302105200 · Cited by 45
Cell Cycle Regulation During Proliferation and Differentiation of Mammalian Muscle Precursor Cells
Ciemerych, M. A., Archacka, K., Grabowska, I., & Gawor, M. (2011) · Results and problems in cell differentiation · doi:10.1007/978-3-642-19065-0_20 · Cited by 47
Springhorn, J. P., Singh, K., Kelly, R. A., & Smith, T. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37665-2 · Cited by 44
Reddy, K. L., Wohlwill, A., Dzitoyeva, S., Lin, M., Holbrook, S. D., & Storti, R. V. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9797 · Cited by 44
Cyclosporin A treatment upregulates Id1 and Smad3 expression and delays skeletal muscle regeneration
Sakuma, K., Nakao, R., Aoi, W., Inashima, S., Fujikawa, T., Hirata, M., Sano, M., & Yasuhara, M. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1049-x · Cited by 43
Hlavacek, W. S., & Savageau, M. A. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1995.0257 · Cited by 43
In vivo filtering of in vitro expression data reveals MyoD targets
Zhao, P., Seo, J., Wang, Z., Wang, Y., Shneiderman, B., & Hoffman, E. P. (2003) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2003.09.035 · Cited by 42
Cellular and molecular diversity in skeletal muscle development: News from in vitro and in vivo
Miller, J. B., Everitt, E. A., Smith, T. H., Block, N. E., & Dominov, J. A. (1993) · BioEssays · doi:10.1002/bies.950150308 · Cited by 42
Hasskarl, J., Duensing, S. M., Manuel, E. R., & Münger, K. (2004) · Oncogene · doi:10.1038/sj.onc.1207310 · Cited by 42
Are fibroblast growth factors regulators of myogenesis in vivo?
Olwin, B. B., Hannon, K., & Kudla, A. J. (1994) · Progress in Growth Factor Research · doi:10.1016/0955-2235(94)90002-7 · Cited by 42
Id proteins in the vasculature: from molecular biology to cardiopulmonary medicine
Yang, J. H., Li, X., & Morrell, N. W. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu215 · Cited by 41
Kuratani, S., Matsuo, I., & Aizawa, S. (1997) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199706)209:2 · Cited by 116
Chen, B. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.2.423 · Cited by 41
Takeda, S., North, D. L., Diagana, T. T., Miyagoe, Y., Lakich, M. M., & Whalen, R. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15664 · Cited by 41
Torres‐Machorro, A. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312855 · Cited by 42
Luan, Y., Yu, X., Yang, N., Frenkel, S. R., Chen, L., & Liu, C.-J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1057 · Cited by 40
Markus, M., & Benezra, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1040 · Cited by 41
Self-citationLymphoid-specific Expression of the Id3 Gene in Hematopoietic Cells
Deed, R. W., Jasiok, M., & Norton, J. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8278 · Cited by 40
Members of the bHLH-PAS family regulateShhtranscription in forebrain regions of the mouse CNS
Epstein, D. J., Martinu, L., Michaud, J. L., Losos, K., Fan, C., & Joyner, A. L. (2000) · Development · doi:10.1242/dev.127.21.4701 · Cited by 40
Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis
Tanaka, A., Itoh, F., Nishiyama, K., Takezawa, T., Kurihara, H., Itoh, S., & Kato, M. (2010) · Blood · doi:10.1182/blood-2009-05-223057 · Cited by 39
Myogenin Protein Stability Is Decreased by BMP-2 through a Mechanism Implicating Id1
Viñals, F., & Ventura, F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408059200 · Cited by 39
XIdx, A dominant negative regulator of bHLH function in early Xenopus embryos
Wilson, R. J., & Mohun, T. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(94)00319-i · Cited by 39
Pagliuca, A., Bartoli, P. C., & Lania, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7668 · Cited by 39
Mukund, K., Mathewson, M. A., Minamoto, V. B., Ward, S. R., Subramaniam, S., & Lieber, R. L. (2014) · Muscle & Nerve · doi:10.1002/mus.24211 · Cited by 39
Inhibitors of DNA Binding in Neural Cell Proliferation and Differentiation
Tzeng, S. (2003) · Neurochemical Research · doi:10.1023/a:1021691911011 · Cited by 38
Trichinella spiralis: Subversion of differentiated mammalian skeletal muscle cells
Jasmer, D. P. (1995) · Parasitology Today · doi:10.1016/0169-4758(95)80155-3 · Cited by 38
Zhang, L., & Wang, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209958 · Cited by 37
Rollin, J., Bléchet, C., Régina, S., Tenenhaus, A., Guyétant, S., & Gidrol, X. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004158 · Cited by 35
Wice, B. M., Bernal‐Mizrachi, E., & Permutt, M. A. (2001) · Diabetologia · doi:10.1007/s001250051643 · Cited by 35
Genomic Organization, Sequence, and Chromosomal Localization of the Human Helix–Loop–Helix Id1 Gene
Nehlin, J. O., Hara, E., Kuo, W.-L., Collins, C. C., & Campisi, J. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6152 · Cited by 35
Progression through G1 and S phases of adult rat hepatocytes
Loyer, P., Ilyin, G. P., Cariou, S., Glaise, D., Corlu, A., & Guguen‐Guillouzo, C. (1996) · Springer eBooks · doi:10.1007/978-1-4615-5873-6_4 · Cited by 37
Robinson, G. L. W. G., Henderson, E., Massari, M. E., Murre, C., & Stein, R. W. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.3.1398 · Cited by 35
Iavarone, A. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00455-5 · Cited by 34
Kobayashi, I., Ono, H., Moritomo, T., Kano, K., Nakanishi, T., & Suda, T. (2009) · Blood · doi:10.1182/blood-2009-07-232322 · Cited by 34
Jossic-Corcos, C. L., Ilyin, G. P., Loyer, P., Glaise, D., Cariou, S., & Guguen‐Guillouzo, C. (1994) · PubMed · Cited by 34
Id Family of Transcription Factors and Vascular Lesion Formation
Forrest, S. T., & McNamara, C. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000143932.03151.ad · Cited by 33
Muir, T., Sadler‐Riggleman, I., & Skinner, M. K. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0473 · Cited by 33
Kim, H., Hong, J. M., Yoon, K., Kim, N., Cho, D., Choi, J., Lee, I. K., & Kim, S. (2012) · Bone · doi:10.1016/j.bone.2012.07.015 · Cited by 33
Alternative Splicing of Transcription Factors Genes in Muscle Physiology and Pathology
Imbriano, C., & Molinari, S. (2018) · Genes · doi:10.3390/genes9020107 · Cited by 35
Ding, B., Liu, C.-J., Huang, Y., Yu, J. H., Kong, W., & Lengyel, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511748200 · Cited by 33
Calcium regulation of basic helix-loop-helix transcription factors
Hermann, S., Saarikettu, J., Onions, J., Hughes, K. A., & Grundström, T. (1998) · Cell Calcium · doi:10.1016/s0143-4160(98)90112-9 · Cited by 33
Cubas, P., Modolell, J., & Ruiz‐Gómez, M. (1994) · Development · doi:10.1242/dev.120.9.2555 · Cited by 33
Muscle‐specific gene expression during myogensis in the mouse
Ontell, M., Ontell, M. P., & BUCKINGHAM, M. E. (1995) · Microscopy Research and Technique · doi:10.1002/jemt.1070300503 · Cited by 33
Salvador-Warts-Hippo Pathway in a Developmental Checkpoint Monitoring Helix-Loop-Helix Proteins
Wang, L.-H., & Baker, N. E. (2015) · Developmental Cell · doi:10.1016/j.devcel.2014.12.002 · Cited by 32
Goldfarb, A., & Lewandowska, K. (1995) · Blood · doi:10.1182/blood.v85.2.465.465 · Cited by 32
Fatigue and its impact on patients with myasthenia gravis
Paul, R. H., Cohen, R. A., Goldstein, J. M., & Gilchrist, J. M. (2000) · Muscle & Nerve · doi:10.1002/1097-4598(200009)23:9 · Cited by 95
Novel Regulation of the Helix-Loop-Helix Protein Id1 by S5a, a Subunit of the 26 S Proteasome
Anand, G., Yin, X., Shahidi, A. K., Grove, L., & Prochownik, E. V. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19140 · Cited by 32
Regulation of the Pro-B-Cell-Specific Enhancer of the Id1 Gene Involves the C/EBP Family of Proteins
Saisanit, S., & Sun, X.-H. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.844 · Cited by 32
Li, Y., Zhang, P., Jiao, K., & Zou, Y. (2009) · Microvascular Research · doi:10.1016/j.mvr.2009.06.011 · Cited by 31
Song, Y. J., Choi, J. H., & Lee, H. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.2291 · Cited by 31
Edhayan, G., Ohara, R. A., Stinson, W. A., Amin, M. A., Isozaki, T., Ha, C. M., Haines, G. K., Morgan, R. L., Campbell, P. L., Arbab, A. S., et al. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-0984-3 · Cited by 31
Uittenbogaard, M. N., Martinka, D. L., & Chiaramello, A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01572.x · Cited by 31
XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence
Innes, A. J., Sun, B., Wagner, V., Brookes, S., McHugh, D., Pombo, J., Porreca, R. M., Dharmalingam, G., Vernia, S., Zuber, J., et al. (2021) · Genes & Development · doi:10.1101/gad.343269.120 · Cited by 30
2 Drosophila Myogenesis and insights into the Role of nautilus
Abmayr, S. M., & Keller, C. A. (1997) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60244-6 · Cited by 30
Helix‐loop‐helix transcription factors regulate Id2 gene promoter activity
Neuman, K., Nornes, H. O., & Neuman, T. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01128-2 · Cited by 30
ID gene activity during Xenopus embryogenesis
Zhang, H., Reynaud-Deonauth, S., Kloc, M., Etkin, L. D., & Spohr, G. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(94)00329-l · Cited by 30
Lingbeck, J. M., Trausch‐Azar, J. S., Ciechanover, A. J., & Schwartz, A. L. (2008) · The FASEB Journal · doi:10.1096/fj.07-095000 · Cited by 29
Inhibitor of DNA binding in heart development and cardiovascular diseases
Hu, W., Xin, Y., Hu, J. J., Sun, Y., & Zhao, Y. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0365-z · Cited by 29
Zhang, Y., Mu, Q., Zhou, H., Vrijens, K., Roussel, M. F., Jiang, G., & Yan, B. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.48 · Cited by 29
Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche
Suh, H. C., Ji, M., Gooya, J. M., Lee, M. K., Klarmann, K. D., & Keller, J. R. (2009) · Blood · doi:10.1182/blood-2008-09-179788 · Cited by 30
Dürr, I., Numberger, M., Berberich, C. E., & Witzemann, V. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.00353.x · Cited by 29
5 Molecular Embryology of Skeletal Myogenesis
Venuti, J. M., & Cserjesi, P. (1996) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60711-5 · Cited by 29
Meinhardt, G., Husslein, P. W., & Knöfler, M. (2004) · Placenta · doi:10.1016/j.placenta.2004.09.005 · Cited by 28
Jin, F. J., Nishida, M., Hara, S., & Koyama, Y. (2011) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2011.10.001 · Cited by 28
Ono, Y., Gnocchi, V. F., Zammit, P. S., & Nagatomi, R. (2009) · Journal of Cell Science · doi:10.1242/jcs.049742 · Cited by 28
McLellan, A. S., Kealey, T., & Langlands, K. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00345.2005 · Cited by 28
IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation
Dörpholz, G., Murgai, A., Jatzlau, J., Horbelt, D., Belverdi, M. P., Heroven, C., Schreiber, I., Wendel, G., Ruschke, K., Stricker, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08676-6 · Cited by 27
Pea3 expression is regulated by FGF signaling in developing retina
McCabe, K. L., McGuire, C. R., & Reh, T. A. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20631 · Cited by 27
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Nogueira, M. M., Mitjavila‐Garcia, M. T., Pesteur, F. L., Filippi, M., Vainchenker, W., Dubart‐Kupperschmitt, A., & Sainteny, F. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3543 · Cited by 27
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Sawai, S., & Campos‐Ortega, J. A. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00071-3 · Cited by 27
Matsue, M., Kageyama, R., Denhardt, D. T., & Noda, M. (1997) · Bone · doi:10.1016/s8756-3282(97)00005-7 · Cited by 27
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Benezra, R. (2001) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(01)00028-2 · Cited by 26
Self-citationMyoR is expressed in nonmyogenic cells and can inhibit their differentiation
Yu, L. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00252-0 · Cited by 25
Mohamed, J. S., Lopez, M. A., Cox, G. A., & Boriek, A. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.434423 · Cited by 25
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Komaki, M., Asakura, A., Rudnicki, M. A., Sodek, J., & Cheifetz, S. (2004) · Journal of Cell Science · doi:10.1242/jcs.00965 · Cited by 25
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Han, S., Cui, C., Wang, Y., He, H., Shen, X., Chen, Y., Liu, Z., Zhu, Q., Li, D., & Yin, H. (2019) · 3 Biotech · doi:10.1007/s13205-019-1735-3 · Cited by 24
Tzeng, S., Bresnahan, J. C., Beattie, M. S., & de Vellis, J. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10089 · Cited by 24
Interleukin-1 β-induced Id2 gene expression is mediated by Egr-1 in vascular smooth muscle cells
ZHU, X., LIN, Y., Bacanamwo, M., CHANG, L., CHAI, R., MASSUD, I., Zhang, J., Garcia-Barrio, M. T., Thompson, W. E., & CHEN, Y. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.06.015 · Cited by 24
CR2/CD21 Proximal Promoter Activity Is Critically Dependent on a Cell Type-Specific Repressor
Ulgiati, D., & Holers, V. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.6912 · Cited by 24
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Goldfarb, A. N., Lewandowska, K., & Shoham, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2683 · Cited by 24
Metadata
- Authors
- Jen, Y., Weintraub, H., & Benezra, R.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- ORCID
- Benezra, R
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1992-08
- Volume
- 6
- Issue
- 8
- Pages
- 1466-1479
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2101927529
- Cited by
- 471
- References
- 47
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 5 · 2021: 10 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 15 · 2013: 4 · 2012: 8
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Id proteins, E12, E47, helix-loop-helix proteins, myogenesis, MyoD, hetero-oligomeric complexes, C2C12 myoblasts, transcriptional repression, myotubes
- MeSH terms
- Animals, Cell Differentiation, Cell Line, DNA-Binding Proteins, Fluorescent Antibody Technique, Muscles, Precipitin Tests, Repressor Proteins, Transcription Factors, Blotting, Northern, Inhibitor of Differentiation Protein 1, TCF Transcription Factors, Transcription Factor 7-Like 1 Protein
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