PreprintCited by 471Muscle Physiology and DisordersDevelopmental Biology and Gene RegulationGenomics and Chromatin Dynamics

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Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins

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Jen, Y, Weintraub, H, Benezra, R·1992·Genes & Development

DOI 10.1101/gad.6.8.1466

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Abstract

The helix-loop-helix (HLH) protein Id lacks the basic DNA-binding domain common to this class of proteins. In vitro experiments suggested that Id could associate tightly with two other HLH proteins encoded by the E2A gene, E12 and E47 (referred to here collectively as E proteins) and prevent their binding to a sequence present in the muscle creatine kinase (MCK) enhancer either as homo-oligomers or hetero-oligomers with MyoD. In this report we present evidence for the in vivo roles of Id and E proteins: (1) Id and E proteins co-fractionate and co-immunoprecipitate in whole-cell extracts prepared from myoblasts; (2) the loss of Id protein observed during the conversion of proliferating myoblasts into mature myotubes correlates with the formation of MyoD/E hetero-oligomeric complexes in whole-cell extracts (these complexes do not form when purified Id protein is added to the extracts); and (3) stable overexpression of Id mRNA and protein in the C2C12 muscle cell line inhibits differentiation in these cells 16 hr post-induction. The myotubes that do eventually form 48 hr post-induction have no detectable Id protein in the nucleus despite the persistence of exogenous Id mRNA. These data support a model in which Id can inhibit muscle cell differentiation by associating with E proteins and preventing them from forming active hetero-oligomeric complexes with the muscle determination gene products.

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Authors: Jen, Y., Weintraub, H., & Benezra, R.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
ORCID: Benezra, R
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1992-08
Volume: 6
Issue: 8
Pages: 1466-1479
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.6.8.1466
OpenAlex: W2101927529
Cited by: 471
References: 47
Citations by year: 2026: 4 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 5 · 2021: 10 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 15 · 2013: 4 · 2012: 8
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: Id proteins, E12, E47, helix-loop-helix proteins, myogenesis, MyoD, hetero-oligomeric complexes, C2C12 myoblasts, transcriptional repression, myotubes
MeSH terms: Animals, Cell Differentiation, Cell Line, DNA-Binding Proteins, Fluorescent Antibody Technique, Muscles, Precipitin Tests, Repressor Proteins, Transcription Factors, Blotting, Northern, Inhibitor of Differentiation Protein 1, TCF Transcription Factors, Transcription Factor 7-Like 1 Protein

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Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins

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