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Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles.
Open accessAbstract
There is increasing evidence that members of the TGF-beta superfamily are important regulators of epithelial growth and differentiation in vivo. Here, transgenic mice have been used to study the role of the TGF-beta-related growth factors BMP-2 and BMP-4 in hair and whisker development. In the mature hair follicle, BMP-2 transcripts are normally seen only in precortex cells at the base of the hair shaft. In the transgenic mice reported here, BMP-4, a closely related molecule, has been ectopically expressed in the outer root sheath of hair and whisker follicles using an expression vector based on the bovine cytokeratin IV* promoter. In response to transgene expression, both outer root sheath cells below the stem cell compartment and hair matrix cells around the dermal papilla cease proliferation. In addition, the expression pattern of cytokeratin markers is disturbed in some transgenic hair follicles. These results support a model in which members of the TGF-beta superfamily play an active role in the inhibiton of cell proliferation and the onset of expression of trichocyte-specific genes that take place when cells leave the matrix of the follicle and differentiate into shaft cells.
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Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
Cited by
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FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R. (1994) · Cell · doi:10.1016/0092-8674(94)90276-3 · Cited by 589
Sano, S., Itami, S., Takeda, K., Tarutani, M., Yamaguchi, Y., Miura, H., Yoshikawa, K., Akira, S., & Takeda, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4657 · Cited by 519
Mechanisms of ectodermal organogenesis.
Pispa, J., & Thesleff, I. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00325-7 · Cited by 499
Some properties of keratin biomaterials: Kerateines
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Metadata
- Authors
- Blessing, M., Nanney, L. B., King, L. E., Jones, C. M., & Hogan, B. L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1993-02
- Volume
- 7
- Issue
- 2
- Pages
- 204-215
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2135203659
- Cited by
- 169
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Blessing, M., Nanney, L. B., King, L. E., Jones, C. M., & Hogan, B. L. (1993). Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles. Genes & Development. https://doi.org/10.1101/gad.7.2.204
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
