The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.
Open accessAbstract
The retinoblastoma protein (p110RB) interacts with many cellular proteins in complexes potentially important for its growth-suppressing function. We have developed and used an improved version of the yeast two-hybrid system to isolate human cDNAs encoding proteins able to bind p110RB. One clone encodes a novel type 1 protein phosphatase catalytic subunit (PP-1 alpha 2), which differs from the originally defined PP-1 alpha by an amino-terminal 11-amino-acid insert. In vitro-binding assays demonstrated that PP-1 alpha isoforms preferentially bind the hypophosphorylated form of p110RB. Moreover, similar p110RB sequences are required for binding PP-1 alpha 2 and SV40 large T antigen. Cell cycle synchrony experiments revealed that this association occurs from mitosis to early G1. The implications of these findings on the regulation of both proteins are discussed.
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Citations
Cites
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017 · cited 3×
“…the adenovirus EIA protein {Whyte et al. 1988), the SV40 T antigen {DeCaprio et al. 19881, and the E7 protein of human papillomavirus 16 (HPVl61 (Dyson et al. 1989}. p110 ~ sequences required for these interactions were mapped to two large domains in the carboxy-terminal portion of the protein…”
BackgroundMethodA human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
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SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family
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Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55 Gag
VerPlank, L., Bouamr, F., LaGrassa, T. J., Agresta, B., Kikonyogo, A., Leis, J., & Carter, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131059198 · Cited by 584
Metadata
- Authors
- Durfee, T., Becherer, K., Chen, P. L., Yeh, S. H., Yang, Y., Kilburn, A. E., Lee, W. H., & Elledge, S. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1993-04
- Volume
- 7
- Issue
- 4
- Pages
- 555-569
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2142946131
- Cited by
- 1,451
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Durfee, T., Becherer, K., Chen, P. L., Yeh, S. H., Yang, Y., Kilburn, A. E., Lee, W. H., & Elledge, S. J. (1993). The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes & Development. https://doi.org/10.1101/gad.7.4.555
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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