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Cited by 1,451

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

Open access
Durfee, T, Becherer, K, Chen, P L, Yeh, S H, Yang, Y, Kilburn, A E, Lee, W H, Elledge, S J·1993·Genes & Development
DOI 10.1101/gad.7.4.555
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Abstract

The retinoblastoma protein (p110RB) interacts with many cellular proteins in complexes potentially important for its growth-suppressing function. We have developed and used an improved version of the yeast two-hybrid system to isolate human cDNAs encoding proteins able to bind p110RB. One clone encodes a novel type 1 protein phosphatase catalytic subunit (PP-1 alpha 2), which differs from the originally defined PP-1 alpha by an amino-terminal 11-amino-acid insert. In vitro-binding assays demonstrated that PP-1 alpha isoforms preferentially bind the hypophosphorylated form of p110RB. Moreover, similar p110RB sequences are required for binding PP-1 alpha 2 and SV40 large T antigen. Cell cycle synchrony experiments revealed that this association occurs from mitosis to early G1. The implications of these findings on the regulation of both proteins are discussed.

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Metadata

Authors
Durfee, T., Becherer, K., Chen, P. L., Yeh, S. H., Yang, Y., Kilburn, A. E., Lee, W. H., & Elledge, S. J.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
1993-04
Volume
7
Issue
4
Pages
555-569
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.7.4.555
OpenAlex
W2142946131
Cited by
1,451
References
5
Type
posted content
Language
en
Open access
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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