The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.
Open accessAbstract
The E2F family of transcription factors controls the expression of genes that are involved in cell cycle regulation. E2F DNA-binding activity is found in complex with the retinoblastoma protein, pRb, and with the pRb-related p107 and p130. To date, cDNAs for three members of the E2F gene family have been isolated. However, all three E2Fs associate in vivo exclusively with pRb. We report here the cloning and functional analysis of a fourth E2F family member. E2F-4 encodes a 413-amino-acid protein with significant homology to E2F-1. E2F-4 antibodies recognize a 60-kD protein in anti-p107 immunoprecipitates, indicating that E2F-4 associates with p107 in vivo. Like the other E2Fs, E2F-4 requires DP-1 for efficient DNA binding and transcriptional activation of E2F site-containing promoters. Increased expression of E2F-4 and DP-1 in SaoS-2 osteosarcoma cells causes a shift from G1-phase cells to S and G2/M-phase cells, suggesting a role for E2F-4 in regulation of cell-cycle progression. We show that expression of E2F-4 and DP-1 together with an activated ras oncogene in rat embryo fibroblasts, causes transformation, indicating that E2F-4 has oncogenic activity.
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Cites
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
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Cited by
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
The regulation of E2F by pRB-family proteins.
Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317
Control of cell cycle transcription during G1 and S phases
Bertoli, C., Skotheim, J. M., & de Bruin, R. A. M. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3629 · Cited by 1,500
Sibling rivalry in the E2F family
Trimarchi, J. M., & Lees, J. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm714 · Cited by 1,158
Role of the p16 tumor suppressor gene in cancer.
Liggett, W. H., & Sidransky, D. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.3.1197 · Cited by 746
Metadata
- Authors
- Beijersbergen, R. L., Kerkhoven, R. M., Zhu, L., Carlée, L., Voorhoeve, P. M., & Bernards, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1994-11-15
- Volume
- 8
- Issue
- 22
- Pages
- 2680-2690
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2061941936
- Cited by
- 322
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. https://app.cochat.ai/papers/10.1101/gad.8.22.2680
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- Beijersbergen, R. L., Kerkhoven, R. M., Zhu, L., Carlée, L., Voorhoeve, P. M., & Bernards, R. (1994). E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes & Development. https://doi.org/10.1101/gad.8.22.2680
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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