The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A common enzyme connects Notch signaling and Alzheimer's disease
Open accessAbstract
Biology in its broadest sense is a multifaceted endeavor aimed at solving a puzzle with a finite, but extremely large, number of pieces. Often it is hard to predict how wide the gap separating two individual bits of knowledge within the larger picture would be. Therefore, when researchers working in diverse fields simultaneously realize that their fragments of the puzzle fit together, what appeared as an insurmountable distance is bridged rapidly as the remaining pieces are fitted into place. Several studies published recently by developmental biologists, neuroscientists, and researchers who are interested in the identification of therapeutic targets and treatments for Alzheimer’s disease (AD) have tied together diverse
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Cites
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · cited 1×
“Expression-cloning studies have recently shown that -secretase is a novel membrane-associated aspartyl protease that has been termed BACE or Asp2 (Hussain et al. 1999; Sinha et al. 1999; Vassar et al. 1999; Yan et al. 1999; Lin et al. 2000).”
BackgroundDeficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., & Van Leuven, F. (1998) · Nature · doi:10.1038/34910 · Cited by 1,818
A regulatory link between ER-associated protein degradation and the unfolded-protein response
Friedlander, R., Jarosch, E., Urban, J., Volkwein, C., & Sommer, T. (2000) · Nature Cell Biology · doi:10.1038/35017001 · Cited by 474
Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons
Naruse, S., Thinakaran, G., Luo, J.-J., Kusiak, J. W., Tomita, T., Iwatsubo, T., Qian, X., Ginty, D. D., Price, D. L., Borchelt, D. R., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80637-6 · Cited by 355 · cited 1×
“Analysis of PS1-deficient animals has revealed that PS1 is required for the -secretase processing of APP and the APLPs (De Strooper et al. 1998; Naruse et al. 1998).”
BackgroundWolfe, M. S., Xia, W., Moore, C. L., Leatherwood, D. D., Ostaszewski, B., Rahmati, T., Donkor, I. O., & Selkoe, D. J. (1999) · Biochemistry · doi:10.1021/bi982562p · Cited by 289
Cited by
van Es, J. H., van Gijn, M. E., Riccio, O., van den Born, M., Vooijs, M., Begthel, H., Cozijnsen, M., Robine, S., Winton, D. J., Radtke, F., et al. (2005) · Nature · doi:10.1038/nature03659 · Cited by 1,543
Hilton, M. J., Tu, X., Wu, X., Bai, S., Zhao, H., Kobayashi, T., Kronenberg, H. M., Teitelbaum, S. L., Ross, F. P., Kopan, R., et al. (2008) · Nature Medicine · doi:10.1038/nm1716 · Cited by 604
Self-citationDrosophila Rhomboid-1 Defines a Family of Putative Intramembrane Serine Proteases
Urban, S., Lee, J. R., & Freeman, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00525-6 · Cited by 567
CD74 Is a Member of the Regulated Intramembrane Proteolysis-processed Protein Family
Becker-Herman, S., Arie, G., Medvedovsky, H., Kerem, A., & Shachar, I. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-04-0327 · Cited by 141
Genetic architecture of Alzheimer's disease
Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126
“, 1995), although it wasn't until 2000 that it was discovered these proteins are critical subunits of the γ-secretase complex responsible for processing of APP (Kopan and Goate, 2000; Esler et al., 2000; Li et al., 2000) and other membrane-bound proteins such as NOTCH (Bekris et al.”
BackgroundSelf-citation
Metadata
- Authors
- Kopan, R., & Goate, A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-11-15
- Volume
- 14
- Issue
- 22
- Pages
- 2799-2806
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1984614832
- Cited by
- 217
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Kopan, R., & Goate, A. (2000). A common enzyme connects Notch signaling and Alzheimer's disease. Genes & Development. https://doi.org/10.1101/gad.836900
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
