Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons
Open accessAbstract
We have examined the trafficking and metabolism of the beta-amyloid precursor protein (APP), an APP homolog (APLP1), and TrkB in neurons that lack PS1. We report that PS1-deficient neurons fail to secrete Abeta, and that the rate of appearance of soluble APP derivatives in the conditioned medium is increased. Remarkably, carboxyl-terminal fragments (CTFs) derived from APP and APLP1 accumulate in PS1-deficient neurons. Hence, PS1 plays a role in promoting intramembrane cleavage and/or degradation of membrane-bound CTFs. Moreover, the maturation of TrkB and BDNF-inducible TrkB autophosphorylation is severely compromised in neurons lacking PS1. We conclude that PS1 plays an essential role in modulating trafficking and metabolism of a selected set of membrane and secretory proteins in neurons.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tail biopsy samples were used to isolate DNA to confirm the genotype of the strain using previously established primers by PCR.
“Tail biopsy samples were used to isolate DNA to confirm the genotype of the strain using previously established primers by PCR93–95.”
From Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis (2025) · cites this paper as [95]
The Results describe cultures from embryos with different PS1 genotypes, but do not say how those genotypes were determined. Searches for tail biopsy, DNA isolation, PCR, and genotyping primers found no passage describing the claimed procedure. (LLM, conf=0.74)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Characteristics of a human cell line transformed by DNA from human adenovirus type 5
Graham, F. L., Russell, W. C., Smiley, J., & Nairn, R. (1977) · Journal of General Virology · doi:10.1099/0022-1317-36-1-59 · Cited by 4,793 · see citing works
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599 · see citing works
Brewer, G. J., Torricelli, J. R., Evege, E. K., & Price, P. J. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490350513 · Cited by 2,094 · see citing works
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., & Van Leuven, F. (1998) · Nature · doi:10.1038/34910 · Cited by 1,818 · see citing works
Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works
Self-citationSuzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Eckman, C., Golde, T. E., & Younkin, S. G. (1994) · Science · doi:10.1126/science.8191290 · Cited by 1,471 · see citing works
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,453 · see citing works
Amyloid, the presenilins and Alzheimer’s disease
Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370 · see citing works
Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-wood, K., Lee, M., Seubert, P., Davis, A., et al. (1997) · Nature Medicine · doi:10.1038/nm0197-67 · Cited by 1,271 · see citing works
Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo
Thinakaran, G., Borchelt, D., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G. J., Ratovitski, T., Davenport, F., Nordstedt, C., Seeger, M., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80291-3 · Cited by 1,009 · see citing works
Self-citationEvidence that production and release of amyloid beta-protein involves the endocytic pathway
Koo, E. H., & Squazzo, S. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32449-3 · Cited by 989 · see citing works
Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing
Sisodia, S. S., Koo, E. H., Beyreuther, K. T., Unterbeck, A., & Price, D. L. (1990) · Science · doi:10.1126/science.1691865 · Cited by 894 · see citing works
Self-citationSkeletal and CNS Defects in Presenilin-1-Deficient Mice
Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J., & Tonegawa, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80244-5 · Cited by 808 · see citing works
Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm
Wong, P. C., Zheng, H., Chen, H., Bêcher, M. W., SIRINATHSINGHJI, D. J. S., Trumbauer, M. E., Chen, H. Y., Price, D. L., der Ploeg, L. H. T. V., & Sisodia, S. S. (1997) · Nature · doi:10.1038/387288a0 · Cited by 712 · see citing works
Self-citationLevitan, D. J., & Greenwald, I. (1995) · Nature · doi:10.1038/377351a0 · Cited by 709 · see citing works
β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
Zheng, H., Jiang, M., Trumbauer, M. E., SIRINATHSINGHJI, D. J. S., Hopkins, R., Smith, D. W., HEAVENS, R. P., Dawson, G. R., Boyce, S., Conner, M. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90073-x · Cited by 699 · see citing works
Self-citationNeurotrophin receptors: A window into neuronal differentiation
Chao, M. V. (1992) · Neuron · doi:10.1016/0896-6273(92)90023-7 · Cited by 689 · see citing works
Kovacs, D. M., Fausett, H. J., Page, K. J., Kim, T., Moir, R. D., Merriam, D. E., Hollister, R. D., Hallmark, O. G., Mancini, R., Felsenstein, K. M., et al. (1996) · Nature Medicine · doi:10.1038/nm0296-224 · Cited by 551 · see citing works
An NGF-TrkA-Mediated Retrograde Signal to Transcription Factor CREB in Sympathetic Neurons
Riccio, A., Pierchala, B. A., Ciarallo, C. L., & Ginty, D. D. (1997) · Science · doi:10.1126/science.277.5329.1097 · Cited by 446 · see citing works
Self-citationProtease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor
Nostrand, W. E. V., Wagner, S. L., Suzuki, M., Choi, B. H., Farrow, J. S., Geddes, J. W., Cotman, C. W., & Cunningham, D. D. (1989) · Nature · doi:10.1038/341546a0 · Cited by 438 · see citing works
Wasco, W., Bupp, K., Magendantz, M., Gusella, J. F., Tanzi, R. E., & Solomon, F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10758 · Cited by 399 · see citing works
Protein Topology of Presenilin 1
Doan, A., Thinakaran, G., Borchelt, D., Slunt, H. H., Ratovitski, T., Podlisny, M. B., Selkoe, D. J., Seeger, M., Gandy, S., Price, D. L., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80232-9 · Cited by 371 · see citing works
Self-citationSchimmöller, F., Singer‐Krüger, B., Schröder, S., Krüger, U., Barlowe, C. K., & Riezman, H. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07119.x · Cited by 339 · see citing works
Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice
von Koch, C. S., Zheng, H., Chen, H., Trumbauer, M. E., Thinakaran, G., der Ploeg, L. H. T. V., Price, D. L., & Sisodia, S. S. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00151-6 · Cited by 336 · see citing works
Self-citationExpression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues
Lee, M. K., Slunt, H. H., Martin, L. J., Thinakaran, G., Kim, G. J., Gandy, S., Seeger, M., Koo, E. H., Price, D. L., & Sisodia, S. S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07513.1996 · Cited by 286 · see citing works
Self-citationSisodia, S., Koo, E., Hoffman, P., Perry, G. L., & Price, D. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-07-03136.1993 · Cited by 284 · see citing works
Self-citationIwatsubo, T., Saido, T. C., Mann, D. M. A., Lee, V. M.-Y., & Trojanowski, J. Q. (1996) · Europe PMC (PubMed Central) · Cited by 248 · see citing works
Self-citationXia, W., Zhang, J., Perez, R. G., Koo, E. H., & Selkoe, D. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8208 · Cited by 236 · see citing works
NGF-stimulated retrograde transport of trkA in the mammalian nervous system.
Ehlers, M., Kaplan, D. R., Price, D. L., & Koliatsos, V. E. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.1.149 · Cited by 235 · see citing works
Self-citationWeidemann, A., Paliga, K., Dürrwang, U., Czech, C., Evin, G. M., Masters, C. L., & Beyreuther, K. T. (1997) · Nature Medicine · doi:10.1038/nm0397-328 · Cited by 211 · see citing works
Belden, W. J., & Barlowe, C. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.43.26939 · Cited by 208 · see citing works
Cook, D. G., Sung, J. C., Golde, T. E., Felsenstein, K. M., Wójczyk, B. S., Tanzi, R. E., Trojanowski, J. Q., Lee, V. M., & Doms, R. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9223 · Cited by 202 · see citing works
Koo, E. H., Squazzo, S. L., Selkoe, D. J., & Koo, C. H. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.5.991 · Cited by 201 · see citing works
Strooper, B. D., Simons, M., Multhaup, G., LEUVEN, F. V., Beyreuther, K. T., & Dotti, C. G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00176.x · Cited by 176 · see citing works
Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP
Thinakaran, G., Regard, J. B., Bouton, C. M. L. S., Harris, C. L., Price, D. L., Borchelt, D., & Sisodia, S. S. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0171 · Cited by 173 · see citing works
Self-citationQian, S., Jiang, P., Guan, X.-M., Singh, G., Trumbauer, M. E., Yu, H. H., Chen, H. Y., der Ploeg, L. H. T. V., & Zheng, H. (1998) · Neuron · doi:10.1016/s0896-6273(00)80999-x · Cited by 169 · see citing works
Light and Electron Microscopic Localization of Presenilin-1 in Primate Brain
Lah, J. J., Heilman, C. J., Nash, N. R., Rees, H. D., Yi, H., Counts, S. E., & Levey, A. I. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-06-01971.1997 · Cited by 168 · see citing works
Elrod‐Erickson, M., & Kaiser, C. A. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.7.1043 · Cited by 162 · see citing works
Simons, M., Strooper, B. D., Multhaup, G., Tienari, P. J., Dotti, C. G., & Beyreuther, K. T. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00899.1996 · Cited by 161 · see citing works
Li, X., & Greenwald, I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7109 · Cited by 158 · see citing works
Davis, J. A., Naruse, S., Chen, H., Eckman, C., Younkin, S. G., Price, D. L., Borchelt, D., Sisodia, S. S., & Wong, P. C. (1998) · Neuron · doi:10.1016/s0896-6273(00)80998-8 · Cited by 131 · see citing works
Self-citationSurvival and maturation of cerebral neurons on poly(l-lysine) surfaces in the absence of serum
Yavin, Z., & Yavin, E. (1980) · Developmental Biology · doi:10.1016/0012-1606(80)90176-1 · Cited by 88 · see citing works
A technical KO of amyloid-β peptide
Haass, C., & Selkoe, D. J. (1998) · Nature · doi:10.1038/34800 · Cited by 53 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [4]4. Chao, M.V Neurotrophin receptorsa window into neuronal differentiation Neuron. 1992; 9:583-593 Full Text (PDF) Scopus (710) PubMed Google Scholar
- [18]18. Kim, K.S ∙ Wen, G.Y ∙ Bancher, C ... Detection and quantitation of amyloid B-peptide with 2 monoclonal antibodies Neurosci. Res. Commun. 1990; 7:113-122 Google Scholar
Cited by
Sorted by citations
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works
Self-citationMembrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashler, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., et al. (1999) · Nature · doi:10.1038/990107 · Cited by 1,438 · see citing works
Lee, J.-H., Yu, W. H., Kumar, A., Lee, S., Mohan, P. S., Peterhoff, C. M., Wolfe, D. M., Martinez-Vicente, M., Massey, A. C., Sovak, G., et al. (2010) · Cell · doi:10.1016/j.cell.2010.05.008 · Cited by 1,212 · see citing works
A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60
Cao, X., & Südhof, T. C. (2001) · Science · doi:10.1126/science.1058783 · Cited by 1,202 · see citing works
Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874 · see citing works
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
Fortini, M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm910 · Cited by 824 · see citing works
Saura, C. A., Choi, S.-Y., Beglopoulos, V., Malkani, S., Zhang, D., Rao, B. S. S., Chattarji, S., Kelleher, R. J., Kandel, E. R., Duff, K., et al. (2004) · Neuron · doi:10.1016/s0896-6273(04)00182-5 · Cited by 757 · see citing works
Molecular pathways to neurodegeneration
Bossy-Wetzel, E., Schwarzenbacher, R., & Lipton, S. A. (2004) · Nature Medicine · doi:10.1038/nm1067 · Cited by 740 · see citing works
Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 670 · see citing works
N OTCH AND P RESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
Selkoe, D. J., & Kopan, R. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131334 · Cited by 630 · see citing works
Proteolytic processing and cell biological functions of the amyloid precursor protein
Strooper, B. D., & Annaert, W. G. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.1857 · Cited by 628 · see citing works
Herreman, A., Hartmann, D., Annaert, W. G., Säftig, P., Craessaerts, K., Serneels, L., Umans, L., Schrijvers, V., Checler, F., Vanderstichele, H., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11872 · Cited by 518 · see citing works
γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?
Sisodia, S. S., & St George-Hyslop, P. H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn785 · Cited by 512 · see citing works
Self-citationFeng, R., Rampon, C., Tang, Y., Shrom, D., Jin, J., Kyin, M., Sopher, B. L., Martin, G. M., Kim, S., Langdon, R. B., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00523-2 · Cited by 467 · see citing works
Self-citationPresenilins and -Secretase: Structure, Function, and Role in Alzheimer DiseasePreprint
Strooper, B. D., Iwatsubo, T., & Wolfe, M. S. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006304 · Cited by 465 · see citing works
Self-citationSuh, Y.-H., & Checler, F. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.469 · Cited by 467 · see citing works
Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H.-C., Xu, G., Koliatsos, V. E., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2766-05.2005 · Cited by 521 · see citing works
Self-citationNeuroplasticity Failure in Alzheimer's Disease
Mesulam, M.-M. (1999) · Neuron · doi:10.1016/s0896-6273(00)81109-5 · Cited by 449 · see citing works
Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes
Vetrivel, K. S., Cheng, H., Lin, W., Sakurai, T., Li, T., Nukina, N., Wong, P. C., Xu, H., & Thinakaran, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407986200 · Cited by 413 · see citing works
Self-citationPresenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1
Zhang, Z., Nadeau, P. M., Song, W., Donoviel, D. B., Yuan, M., Bernstein, A., & Yankner, B. A. (2000) · Nature Cell Biology · doi:10.1038/35017108 · Cited by 404 · see citing works
The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key
Haass, C., & Strooper, B. D. (1999) · Science · doi:10.1126/science.286.5441.916 · Cited by 388 · see citing works
Transport-Dependent Proteolysis of SREBP
DeBose‐Boyd, R. A., Brown, M. S., Li, W., Nohturfft, A., Goldstein, J. L., & Espenshade, P. J. (1999) · Cell · doi:10.1016/s0092-8674(00)81668-2 · Cited by 326 · see citing works
Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
Small, S. A., & Gandy, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.001 · Cited by 320 · see citing works
The role of protein glycosylation in Alzheimer disease
Schedin‐Weiss, S., Winblad, B. G., & Tjernberg, L. O. (2013) · FEBS Journal · doi:10.1111/febs.12590 · Cited by 316 · see citing works
Liang, W. S., Dunckley, T., Beach, T. G., Grover, A., Mastroeni, D., Ramsey, K., Caselli, R. J., Kukull, W. A., McKeel, D., Morris, J. C., et al. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00242.2007 · Cited by 309 · see citing works
Annaert, W. G., Lévesque, L., Craessaerts, K., Dierinck, I., Snellings, G., Westaway, D. A., George‐Hyslop, P. S., Cordell, B., Fraser, P., & Strooper, B. D. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.277 · Cited by 311 · see citing works
Presenilin-Mediated Modulation of Capacitative Calcium Entry
Yoo, A. S. J., Cheng, I., Chung, S., Grenfell‐Lee, T. Z., Lee, H., Pack-Chung, E., Handler, M., Shen, J., Xia, W., Tesco, G., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00066-0 · Cited by 309 · see citing works
An overview of the Notch signalling pathway
Baron, M. (2003) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(02)00179-9 · Cited by 306 · see citing works
Steiner, H., Duff, K., Capell, A., Romig, H., Grim, M. G., Lincoln, S., Hardy, J., Yu, X., Picciano, M., Fechteler, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28669 · Cited by 303 · see citing works
Self-citationAlzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport
Pigino, G. F., Morfini, G. A., Pelsman, A., Mattson, M. P., Brady, S. T., & Busciglio, J. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04499.2003 · Cited by 300 · see citing works
Deciphering the Genetic Basis of Alzheimer's Disease
Selkoe, D. J., & Podlisny, M. B. (2002) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.3.022502.103022 · Cited by 293 · see citing works
Gu, Y., Misonou, H., Sato, T., Dohmae, N., Takio, K., & Ihara, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100357200 · Cited by 292 · see citing works
Wong, H. K., Sakurai, T., Oyama, F., Kaneko, K., Wada, K., Miyazaki, H., Kurosawa, M., Strooper, B. D., Säftig, P., & Nukina, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414648200 · Cited by 290 · see citing works
Wnt signaling function in Alzheimer’s disease
Ferrari, G. V. D., & Inestrosa, N. C. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00021-7 · Cited by 288 · see citing works
Advances in developing novel therapeutic strategies for Alzheimer’s disease
Cao, J., Hou, J., Ping, J., & Cai, D. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0299-8 · Cited by 283 · see citing works
Steiner, H., Winkler, E., Edbauer, D., Prokop, S., Basset, G., Yamasaki, A., Kostka, M., & Haass, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200469200 · Cited by 281 · see citing works
Buxbaum, J. D., Thinakaran, G., Koliatsos, V. E., O’Callahan, J., Slunt, H. H., Price, D. L., & Sisodia, S. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09629.1998 · Cited by 266 · see citing works
Self-citationCell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch
Ray, W. J., Yao, M., Mumm, J. S., Schroeter, E. H., Säftig, P., Wolfe, M. S., Selkoe, D. J., Kopan, R., & Goate, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36801 · Cited by 266 · see citing works
Pappolla, M. A., Chyan, Y., Pöeggeler, B., Frangione, B., Wilson, G. L., Ghiso, J. A., & Reiter, R. J. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050018 · Cited by 239 · see citing works
Dewachter, I., Reversé, D., Caluwaerts, N., Ris, L., Kuipéri, C., den Haute, C. V., Spittaels, K., Umans, L., Serneels, L., Thiry, E., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03445.2002 · Cited by 236 · see citing works
Cai, J., Jiang, W. G., Grant, M. B., & Boulton, M. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507401200 · Cited by 235 · see citing works
RetractedCupers, P., Orlans, I., Craessaerts, K., Annaert, W. G., & Strooper, B. D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00516.x · Cited by 234 · see citing works
Amyloid-beta precursor protein processing in neurodegeneration
Wilquet, V., & Strooper, B. D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.08.001 · Cited by 230 · see citing works
Ho, A., & Südhof, T. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308655100 · Cited by 224 · see citing works
Ling, Y., Morgan, K., & Kalsheker, N. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(03)00133-x · Cited by 224 · see citing works
Georgakopoulos, A., Marambaud, P., Efthimiopoulos, S., Shioi, J., Cui, W., Li, H., Schütte, M., Gordon, R., Holstein, G. R., Martinelli, G. P., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80219-1 · Cited by 221 · see citing works
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
Li, Q., & Südhof, T. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310001200 · Cited by 219 · see citing works
A common enzyme connects Notch signaling and Alzheimer's diseasePreprint
Kopan, R., & Goate, A. (2000) · Genes & Development · doi:10.1101/gad.836900 · Cited by 217 · see citing works
The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
Zhang, X., & Song, W. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt211 · Cited by 216 · see citing works
Neurotrophins and neurodegeneration
Dawbarn, D., & Allen, S. J. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.00487.x · Cited by 210 · see citing works
Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ
Yu, C., Kim, S.-H., Ikeuchi, T., Xu, H., Gasparini, L., Wang, R., & Sisodia, S. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100410200 · Cited by 210 · see citing works
Self-citationEggert, S., Paliga, K., Soba, P., Evin, G. M., Masters, C. L., Weidemann, A., & Beyreuther, K. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311601200 · Cited by 209 · see citing works
A Cell Biological Perspective on Alzheimer's Disease
Annaert, W. G., & Strooper, B. D. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.020402.142302 · Cited by 218 · see citing works
Presenilin, Notch, and the genesis and treatment of Alzheimer's disease
Selkoe, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211352598 · Cited by 202 · see citing works
β-Amyloid impairs axonal BDNF retrograde trafficking
Poon, W. W., Blurton-Jones, M. M., Tu, C. H., Feinberg, L. M., Chabrier, M. A., Harris, J. W., Jeon, N. L., & Cotman, C. W. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.012 · Cited by 198 · see citing works
Ikeuchi, T., & Sisodia, S. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200711200 · Cited by 196 · see citing works
Self-citationHerreman, A., Gassen, G. V., Bentahir, M., Nyabi, O., Craessaerts, K., Mueller, U., Annaert, W. G., & Strooper, B. D. (2003) · Journal of Cell Science · doi:10.1242/jcs.00292 · Cited by 195 · see citing works
APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1
Jankowsky, J. L., Slunt, H. H., Gonzales, V., Jenkins, N. A., Copeland, N. G., & Borchelt, D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.008 · Cited by 189 · see citing works
Self-citationPresenilin 1 Is Required for Maturation and Cell Surface Accumulation of Nicastrin
Leem, J. Y., Vijayan, S., Han, P., Cai, D., Machura, M., Radomski, K. L., Veselits, M., Xu, H., & Thinakaran, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200148200 · Cited by 182 · see citing works
Self-citationWoodruff, G., Young, J. E., Martinez, F. J., Buen, F., Gore, A., Kinaga, J., Li, Z., Yuan, S. H., Zhang, K., & Goldstein, L. S. B. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.018 · Cited by 177 · see citing works
Li, T., Ma, G., Cai, H., Price, D. L., & Wong, P. C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03272.2003 · Cited by 178 · see citing works
Self-citationNicastrin Is Required for γ-Secretase Cleavage of the Drosophila Notch Receptor
Hu, Y., Ye, Y., & Fortini, M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(01)00105-8 · Cited by 174 · see citing works
Identification of a novel family of presenilin homologues
Ponting, C. P. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.9.1037 · Cited by 173 · see citing works
Neuroplasticity in Alzheimer's disease
Teter, B., & Ashford, J. W. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10441 · Cited by 170 · see citing works
Esselens, C. W., Oorschot, V. M. J., Baert, V., Raemaekers, T., Spittaels, K., Serneels, L., Zheng, H., Säftig, P., Strooper, B. D., Klumperman, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200406060 · Cited by 170 · see citing works
Biogenesis and metabolism of Alzheimer’s disease Aβ amyloid peptides
Evin, G. M., & Weidemann, A. (2002) · Peptides · doi:10.1016/s0196-9781(02)00063-3 · Cited by 170 · see citing works
Torroja, L., Chu, H., Kotovsky, I., & White, K. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80215-2 · Cited by 203 · see citing works
Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities
Lai, M., Chen, E., Crouthamel, M., DiMuzio‐Mower, J., Xu, M., Huang, Q., Price, E. A., Register, R. B., Shi, X., Donoviel, D. B., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300974200 · Cited by 167 · see citing works
Alzheimer disease γ-secretase: a complex story of GxGD-type presenilin proteases
Haass, C., & Steiner, H. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02394-2 · Cited by 165 · see citing works
H UMAN N EURODEGENERATIVE D ISEASE M ODELING U SING D ROSOPHILA
Bonini, N. M., & Fortini, M. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131425 · Cited by 163 · see citing works
Saura, C. A., Chen, G., Malkani, S., Choi, S.-Y., Takahashi, R. H., Zhang, D., Gouras, G. K., Kirkwood, A., Morris, R. G. M., & Shen, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1247-05.2005 · Cited by 157 · see citing works
Cupers, P., Bentahir, M., Craessaerts, K., Orlans, I., Vanderstichele, H., Säftig, P., Strooper, B. D., & Annaert, W. G. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200104045 · Cited by 158 · see citing works
Mature Glycosylation and Trafficking of Nicastrin Modulate Its Binding to Presenilins
Yang, D.-S., Tandon, A., Chen, F., Yu, G., Yu, W. H., Arawaka, S., Hasegawa, H. H., Duthie, M., Schmidt, S. D., Ramabhadran, T. V., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110871200 · Cited by 157 · see citing works
Presenilins and Alzheimer’s disease: biological functions and pathogenic mechanisms
Czech, C., Tremp, G. L., & Pradier, L. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00033-7 · Cited by 155 · see citing works
Pathological and physiological functions of presenilins
Vetrivel, K. S., Zhang, Y., Xu, H., & Thinakaran, G. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-4 · Cited by 158 · see citing works
Self-citationPartial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
Farmery, M. R., Tjernberg, L. O., Pursglove, S. E., Bergman, A., Winblad, B. G., & Näslund, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211992200 · Cited by 152 · see citing works
Alzheimer’s disease: How metal ions define β-amyloid function
Kepp, K. P. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.05.007 · Cited by 151 · see citing works
Presenilin diversifies its portfolio
Parks, A. L., & Curtis, D. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.01.008 · Cited by 150 · see citing works
Landman, N., Jeong, S. Y., Shin, S. Y., Voronov, S. V., Serban, G., Kang, M. S., Park, M. K., Di Paolo, G., Chung, S., & Kim, T.-W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604954103 · Cited by 149 · see citing works
Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch
Capell, A., Steiner, H., Romig, H., Keck, S., Baader, M., Grim, M. G., Baumeister, R., & Haass, C. (2000) · Nature Cell Biology · doi:10.1038/35008626 · Cited by 147 · see citing works
Secretase inhibitors and modulators for Alzheimer’s disease treatment
Tomita, T. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.24 · Cited by 146 · see citing works
Self-citationTHE GENETICS AND MOLECULAR PATHOLOGY OF ALZHEIMER'S DISEASE
Selkoe, D. J. (2000) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70232-2 · Cited by 146 · see citing works
Hornsten, A., Lieberthal, J. G., Fadia, S., Malins, R., Ha, L., Xu, X., Daigle, I., Markowitz, M. K., O'Connor, G., Plasterk, R. H. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603997104 · Cited by 146 · see citing works
Presenilin function and γ‐secretase activity
Brunkan, A. L., & Goate, A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03099.x · Cited by 144 · see citing works
The APP family of proteins: similarities and differences
Walsh, D. M., Minogue, A. M., Frigerio, C. S., Fadeeva, J. V., Wasco, W., & Selkoe, D. J. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350416 · Cited by 145 · see citing works
Presenilins: molecular switches between proteolysis and signal transduction
Annaert, W. G., & Strooper, B. D. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01455-1 · Cited by 142 · see citing works
CD74 Is a Member of the Regulated Intramembrane Proteolysis-processed Protein Family
Becker-Herman, S., Arie, G., Medvedovsky, H., Kerem, A., & Shachar, I. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-04-0327 · Cited by 141 · see citing works
Activation and intrinsic γ-secretase activity of presenilin 1
Ahn, K., Shelton, C. C., Tian, Y., Zhang, X., Gilchrist, M. L., Sisodia, S. S., & Li, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013246107 · Cited by 139 · see citing works
Self-citationBiochemistry and Molecular Biology of Amyloid β‐Protein and the Mechanism of Alzheimer's Disease
(2008) · Handbook of Clinical Neurology · doi:10.1016/s0072-9752(07)01223-7 · Cited by 137 · see citing works
Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors
Jacobsen, K. T., & Iverfeldt, K. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0020-8 · Cited by 139 · see citing works
Hartmann, D., Strooper, B. D., & Säftig, P. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80331-5 · Cited by 136 · see citing works
Sato, N., Urano, F., Leem, J. Y., Kim, S., Li, M., Donoviel, D. B., Bernstein, A., Lee, A. S., Ron, D., Veselits, M., et al. (2000) · Nature Cell Biology · doi:10.1038/35046500 · Cited by 134 · see citing works
Self-citationLazarov, O., Morfini, G. A., Pigino, G. F., Gadadhar, A., Chen, X., Robinson, J., Ho, H., Brady, S. T., & Sisodia, S. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4272-06.2007 · Cited by 135 · see citing works
Self-citationA plasticity-based theory of the pathogenesis of Alzheimer's disease.
MESULAM, M. ‐. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05559.x · Cited by 130 · see citing works
Cai, D., Leem, J. Y., Greenfield, J. P., Wang, P., Kim, B. S., Wang, R., Radomski, K. L., Kim, S.-H., Zheng, H., Greengard, P., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209065200 · Cited by 132 · see citing works
Self-citationXia, W., Ray, W. J., Ostaszewski, B. L., Rahmati, T., Kimberly, W. T., Wolfe, M. S., Zhang, J., Goate, A., & Selkoe, D. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9299 · Cited by 133 · see citing works
Intramembrane proteolysis by presenilins
Steiner, H., & Haass, C. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043065 · Cited by 161 · see citing works
NFκB-dependent Control of BACE1 Promoter Transactivation by Aβ42
Buggia-Prévot, V., Sévalle, J., Roßner, S., & Checler, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706579200 · Cited by 125 · see citing works
Presenilins: Members of the γ-Secretase Quartets, But Part-Time Soloists Too
Wakabayashi, T., & Strooper, B. D. (2008) · Physiology · doi:10.1152/physiol.00009.2008 · Cited by 124 · see citing works
- Authors
- Naruse, S., Thinakaran, G., Luo, J.-J., Kusiak, J. W., Tomita, T., Iwatsubo, T., Qian, X., Ginty, D. D., Price, D. L., Borchelt, D. R., Wong, P. C., & Sisodia, S. S.
- Affiliations
- University of Chicago (US)
- Johns Hopkins University (US)
- National Institute on Aging (US)
- The University of Tokyo (JP)
- Corresponding author
- Sisodia, Sangram S
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 21
- Issue
- 5
- Pages
- 1213-1221
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1994453752
- Cited by
- 355
- References
- 43
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 12 · 2012: 7
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (1PO1 AG 14248, P50AG005146, P01AG014248, AG 05146)
- National Institute of Neurological Disorders and Stroke (NS-20471)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- presenilin 1, APP, APLP1, amyloid-beta, carboxyl-terminal fragment, membrane protein trafficking, TrkB, brain-derived neurotrophic factor, autophosphorylation, intramembrane cleavage, protein degradation, Alzheimer's disease, neurons
- MeSH terms
- Alzheimer Disease, Animals, Cells, Cultured, Cerebral Cortex, Fetus, Membrane Proteins, Molecular Sequence Data, Neurons, Amyloid beta-Protein Precursor, Mice, Knockout, Mice, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review