The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo
Open accessAbstract
Retinoic acid (RA), a derivative of vitamin A, plays a pivotal role in vertebrate development. The level of RA may be determined by the balance between its synthesis and degradation. We have examined the role of CYP26, a P450 enzyme that may degrade RA, by generating mutant mice that lack CYP26. CYP26−/− mice exhibited anomalies, including caudal agenesis, similar to those induced by administration of excess RA. The concentration of endogenous RA, as revealed by marker gene activity, was markedly increased in the tailbud of the mutant animals, in which CYP26 is normally expressed. Expression of T (Brachyury) and Wnt3a in the tailbud was down-regulated in CYP26−/− mice, which may underlie the caudal truncation. The lack of CYP26 also resulted in homeotic transformation of vertebrae as well as in misspecification of the rostral hindbrain associated with anterior expansion of RA-positive domains. These results suggest that local degradation of RA by CYP26 is required for establishing an uneven distribution of RA along the anterio-posterior axis, which is essential for patterning the hindbrain, vertebrae, and tailbud.
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Cites
Wood, H. B., & Episkopou, V. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00116-1 · Cited by 550 · cited 2×
“5) Expression domains of Sox2 (a marker for neural tissue; Kamachi et al. 1998; Wood and Episkopou 1999) were markedly expanded in the caudal region of CYP26−/− embryos (Fig.”
BackgroundIdentification of the Retinoic Acid-inducible All-trans-retinoic Acid 4-Hydroxylase
White, J. A., Guo, Y.-D., Baetz, K., Beckett-Jones, B., Bonasoro, J., Hsu, K. E., Dilworth, F. J., Jones, G., & Petkovich, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.29922 · Cited by 382
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Retinoic acid signalling during development
Rhinn, M., & Dollé, P. (2012) · Development · doi:10.1242/dev.065938 · Cited by 849
Retinoic acid in development: Towards an integrated view
Niederreither, K., & Dollé, P. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2340 · Cited by 726
Human cytochromes P450 in health and disease
Nebert, D. W., Wikvall, K., & Miller, W. L. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0431 · Cited by 505
T HE R OLE OF V ITAMIN A IN M AMMALIAN R EPRODUCTION AND E MBRYONIC D EVELOPMENT
Clagett-Dame, M., & DeLuca, H. F. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102745e · Cited by 461
Metadata
- Authors
- Sakai, Y., Meno, C., Fujii, H., Nishino, J., Shiratori, H., Saijoh, Y., Rossant, J., & Hamada, H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-01-15
- Volume
- 15
- Issue
- 2
- Pages
- 213-225
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2156684099
- Cited by
- 456
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Sakai, Y., Meno, C., Fujii, H., Nishino, J., Shiratori, H., Saijoh, Y., Rossant, J., & Hamada, H. (2001). The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes & Development. https://doi.org/10.1101/gad.851501
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