The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Wnt signals from the neural tube block ectopic cardiogenesis
Open accessAbstract
It has long been observed that repressive signals from the neural tube block cardiogenesis in vertebrates. Here we show that a signal from the neural tube that blocks cardiogenesis in the adjacent anterior paraxial mesoderm of stage 8–9 chick embryos can be mimicked by ectopic expression of either Wnt-3a or Wnt-1, both of which are expressed in the dorsal neural tube. Repression of cardiogenesis by the neural tube can be overcome by ectopic expression of a secreted Wnt antagonist. On the basis of both in vitro and in vivo results, we propose that Wnt signals from the neural tube normally act to block cardiogenesis in the adjacent anterior paraxial mesendoderm.
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Citations
Cites
Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518 · cited 1×
“In Drosophila, the BMP family member, dpp (Frasch 1995), and the Wnt family member, wingless (Wu et al. 1995), are required for the maintained expression of the NK homeobox gene tinman and for subsequent cardiogenesis.”
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Cited by
Kattman, S. J., Witty, A. D., Gagliardi, M., Dubois, N. C., Niapour, M., Hotta, A., Ellis, J., & Keller, G. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.12.008 · Cited by 1,159
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509
Cardiomyocyte Cell Cycle Regulation
Pasumarthi, K. B. S., & Field, L. J. (2002) · Circulation Research · doi:10.1161/01.res.0000020201.44772.67 · Cited by 466
Glycogen Synthase Kinase-3β: A Novel Regulator of Cardiac Hypertrophy and Development
Hardt, S. E., & Sadoshima, J. (2002) · Circulation Research · doi:10.1161/01.res.0000018952.70505.f1 · Cited by 438
Heads or tails: Wnts and anterior–posterior patterning
Yamaguchi, T. P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00417-1 · Cited by 276
Metadata
- Authors
- Tzahor, E., & Lassar, A. B.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-02-01
- Volume
- 15
- Issue
- 3
- Pages
- 255-260
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2135558073
- Cited by
- 246
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Tzahor, E., & Lassar, A. B. (2001). Wnt signals from the neural tube block ectopic cardiogenesis. Genes & Development. https://doi.org/10.1101/gad.871501
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