The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Glycogen Synthase Kinase-3β: A Novel Regulator of Cardiac Hypertrophy and Development
Open accessAbstract
Glycogen synthase kinase-3β (GSK-3β) is a ubiquitously expressed constitutively active serine/threonine kinase that phosphorylates cellular substrates and thereby regulates a wide variety of cellular functions, including development, metabolism, gene transcription, protein translation, cytoskeletal organization, cell cycle regulation, and apoptosis. The activity of GSK-3β is negatively regulated by protein kinase B/Akt and by the Wnt signaling pathway. Increasing lines of evidence show that GSK-3β is an essential negative regulator of cardiac hypertrophy and that the inhibition of GSK-3β by hypertrophic stimuli is an important mechanism contributing to the development of cardiac hypertrophy. GSK-3β also plays an important role in regulating cardiac development. In this review, the role of GSK-3β in cardiac hypertrophy and development and the potential underlying mechanisms are discussed.
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Cited by
Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases
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Skeletal muscle hypertrophy and atrophy signaling pathways
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Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
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Metadata
- Authors
- Hardt, S. E., & Sadoshima, J.
- Venue
- Circulation Research
- Published
- 2002-05-31
- Volume
- 90
- Issue
- 10
- Pages
- 1055-1063
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2170208738
- Cited by
- 438
- References
- 132
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hardt, S. E., & Sadoshima, J. (2002). Glycogen Synthase Kinase-3β: A Novel Regulator of Cardiac Hypertrophy and Development. Circulation Research. https://doi.org/10.1161/01.res.0000018952.70505.f1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
