The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works

Mutations affecting segment number and polarity in Drosophila

Nüsslein‐Volhard, C., & Wieschaus, E. F. (1980) · Nature · doi:10.1038/287795a0 · Cited by 4,370 · see citing works

β‐catenin is a target for the ubiquitin–proteasome pathway

Aberle, H., Bauer, A., Stappert, J., Kispert, A., & Kemler, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3797 · Cited by 2,533 · see citing works

Isolation and characterization

Turksen, K. (2006) · Humana Press eBooks · Cited by 2,082 · see citing works

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

Liu, C., Li, Y., Semënov, M. V., Han, C., Baeg, G., Tan, Y., Zhang, Z., Lin, X., & He, X. (2002) · Cell · doi:10.1016/s0092-8674(02)00685-2 · Cited by 2,066 · see citing works

A Second Canon

Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359 · see citing works

LDL-receptor-related proteins in Wnt signal transduction

Tamai, K., Semënov, M. V., Kato, Y., Spokony, R. F., Liu, C., Katsuyama, Y., Hess, F. J., Saint‐Jeannet, J., & He, X. (2000) · Nature · doi:10.1038/35035117 · Cited by 1,334 · see citing works

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.Preprint

Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167 · see citing works

An LDL-receptor-related protein mediates Wnt signalling in mice

Pinson, K. I., Brennan, J., Monkley, S. J., Avery, B. J., & Skarnes, W. C. (2000) · Nature · doi:10.1038/35035124 · Cited by 1,086 · see citing works

LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044 · see citing works

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013 · see citing works

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., Lee, J. J., Tilghman, S. M., Gumbiner, B. M., & Costantini, F. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80324-4 · Cited by 907 · see citing works

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

Wehrli, M., Dougan, S. T., Caldwell, K. A., O’Keefe, L. V., Schwartz, S. L., Vaizel-Ohayon, D., Schejter, E. D., Tomlinson, A., & DiNardo, S. (2000) · Nature · doi:10.1038/35035110 · Cited by 871 · see citing works

Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842 · see citing works

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

Harland, R., & Gerhart, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.611 · Cited by 839 · see citing works

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · cited 2× · see citing works

Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801 · see citing works

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O. A., Jenny, A., et al. (2005) · Nature Genetics · doi:10.1038/ng1552 · Cited by 767 · see citing works

Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathwayPreprint

Amit, S., Hatzubai, A., Birman, Y., Andersen, J., Ben-Shushan, E., Mann, M., Ben‐Neriah, Y., & Alkalay, I. (2002) · Genes & Development · doi:10.1101/gad.230302 · Cited by 754 · see citing works

Dishevelled controls cell polarity during Xenopus gastrulation

Wallingford, J. B., Rowning, B. A., Vogeli, K. M., Rothbächer, U., Fraser, S. E., & Harland, R. M. (2000) · Nature · doi:10.1038/35011077 · Cited by 751 · see citing works

Shaping the Vertebrate Body Plan by Polarized Embryonic Cell Movements

Keller, R. E. (2002) · Science · doi:10.1126/science.1079478 · Cited by 716 · see citing works

Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways

Miller, J. R., Hocking, A. M., Brown, J. D., & Moon, R. T. (1999) · Oncogene · doi:10.1038/sj.onc.1203245 · Cited by 689 · see citing works

Xwnt11is a target ofXenopusBrachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway

Tada, M., & Smith, J. C. (2000) · Development · doi:10.1242/dev.127.10.2227 · Cited by 675 · see citing works

Developmental systems : insects

Counce, S. J., & Waddington, C. H. (1972) · Academic Press eBooks · Cited by 660 · see citing works

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathwaysPreprint

Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., & Perrimon, N. (1998) · Genes & Development · doi:10.1101/gad.12.16.2610 · Cited by 659 · see citing works

Convergent Extension

Wallingford, J. B., Fraser, S. E., & Harland, R. M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00197-1 · Cited by 613 · see citing works

Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

Habas, R., Dawid, I. B., & He, X. (2003) · Genes & Development · doi:10.1101/gad.1022203 · Cited by 603 · see citing works

WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W. (2000) · Nature · doi:10.1038/35025063 · Cited by 599 · see citing works

The role of RhoA in tissue polarity and Frizzled signalling

Strutt, D. I., Weber, U., & Mlodzik, M. (1997) · Nature · doi:10.1038/387292a0 · Cited by 560 · see citing works

Drosophila Rho-Associated Kinase (Drok) Links Frizzled-Mediated Planar Cell Polarity Signaling to the Actin Cytoskeleton

Winter, C. G., Wang, B., Ballew, A. C., Royou, A., Karess, R. E., Axelrod, J. D., & Luo, L. (2001) · Cell · doi:10.1016/s0092-8674(01)00298-7 · Cited by 555 · see citing works

Identification of a Wnt/Dvl/β-Catenin → Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development

Kioussi, C., Briata, P., Baek, S. H., Rose, D. W., Hamblet, N. S., Herman, T., Ohgi, K. A., Lin, C. R., Gleiberman, A. S., Wang, J., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01084-x · Cited by 543 · see citing works

Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis

Pandur, P., Läsche, M., Eisenberg, L. M., & Kühl, M. (2002) · Nature · doi:10.1038/nature00921 · Cited by 536 · see citing works

Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled

Wong, H.-C., Bourdelas, A., Krauss, A., Lee, H., Shao, Y., Wu, D., Mlodzik, M., Shi, D., & Zheng, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00427-1 · Cited by 531 · see citing works

Maternal Wnt11 Activates the Canonical Wnt Signaling Pathway Required for Axis Formation in Xenopus Embryos

Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie, C. C., Lin, X., & Heasman, J. (2005) · Cell · doi:10.1016/j.cell.2005.01.013 · Cited by 510 · see citing works

Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements

Jessen, J. R., Topczewski, J., Bingham, S., Sepich, D. S., Marlow, F., Chandrasekhar, A., & Solnica-Krezel, L. (2002) · Nature Cell Biology · doi:10.1038/ncb828 · Cited by 504 · see citing works

PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates

Lu, X., Borchers, A., Jolicoeur, C., Rayburn, H., Baker, J. C., & Tessier‐Lavigne, M. (2004) · Nature · doi:10.1038/nature02677 · Cited by 496 · see citing works

An actin nucleation mechanism mediated by Bni1 and Profilin

Sagot, I., Rodal, A. A., Moseley, J. B., Goode, B. L., & Pellman, D. S. (2002) · Nature Cell Biology · doi:10.1038/ncb834 · Cited by 493 · see citing works

Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development

Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C. (2005) · Nature Neuroscience · doi:10.1038/nn1374 · Cited by 485 · see citing works

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in aG-protein-dependent manner

Sheldahl, L. C., Park, M., Malbon, C. C., & Moon, R. T. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80310-8 · Cited by 475 · see citing works

Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1

Lijam, N., Paylor, R., McDonald, M. P., Crawley, J. N., Deng, C.-X., Herrup, K., Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80354-2 · Cited by 470 · see citing works

A frizzled homolog functions in a vertebrate Wnt signaling pathway

Yang-Snyder, J., Miller, J. R., Brown, J. D., Lai, C.-J., & Moon, R. T. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70716-1 · Cited by 469 · see citing works

Wnt Signaling Controls the Phosphorylation Status of β-Catenin

van Noort, M., Meeldijk, J., van der Zee, R., Destrée, O., & Clevers, H. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111635200 · Cited by 468 · see citing works

Mammalian Ryk Is a Wnt Coreceptor Required for Stimulation of Neurite Outgrowth

Lu, W., Yamamoto, V. N., Ortega, B., & Baltimore, D. (2004) · Cell · doi:10.1016/j.cell.2004.09.019 · Cited by 466 · see citing works

Prickle Mediates Feedback Amplification to Generate Asymmetric Planar Cell Polarity Signaling

Tree, D., Shulman, J. M., Rousset, R., Scott, M. P., Gubb, D., & Axelrod, J. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00715-8 · Cited by 460 · see citing works

Wingless gradient formation in the Drosophila wing

Strigini, M., & Cohen, S. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00378-x · Cited by 454 · see citing works

The Zebrafish Glypican Knypek Controls Cell Polarity during Gastrulation Movements of Convergent Extension

Topczewski, J., Sepich, D. S., Myers, D. C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J. H., & Solnica‐Krezel, L. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00005-3 · Cited by 454 · see citing works

JNK functions in the non‐canonical Wnt pathway to regulate convergent extension movements in vertebrates

Yamanaka, H., Moriguchi, T., Masuyama, N., Kusakabe, M., Hanafusa, H., Takada, R., Takada, S., & Nishida, E. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf008 · Cited by 454 · see citing works

Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signalingPreprint

Axelrod, J. D. (2001) · Genes & Development · doi:10.1101/gad.890501 · Cited by 449 · see citing works

Casein kinase I transduces Wnt signals

Peters, J. M., McKay, R. M., McKay, J. P., & Graff, J. M. (1999) · Nature · doi:10.1038/43830 · Cited by 447 · see citing works

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure

Hamblet, N. S., Lijam, N., Ruiz‐Lozano, P., Wang, J., Yang, Y., Luo, Z., Mei, L., Chien, K. R., Sussman, D. J., & Wynshaw-Boris, A. J. (2002) · Development · doi:10.1242/dev.00164 · Cited by 438 · see citing works

Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation

Gong, Y., Mo, C., & Fraser, S. E. (2004) · Nature · doi:10.1038/nature02796 · Cited by 420 · see citing works

Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled

Axelrod, J. D., Matsuno, K., Artavanis‐Tsakonas, S., & Perrimon, N. (1996) · Science · doi:10.1126/science.271.5257.1826 · Cited by 418 · see citing works

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.Preprint

Klingensmith, J., Nusse, R., & Perrimon, N. (1994) · Genes & Development · doi:10.1101/gad.8.1.118 · Cited by 409 · see citing works

Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway

Larabell, C. A., Torres, M. A., Rowning, B. A., Yost, C., Miller, J. R., Wu, M., Kimelman, D., & Moon, R. T. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.5.1123 · Cited by 407 · see citing works

Analysis of Dishevelled signalling pathways during Xenopus development

Sokol, S. Y. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00750-6 · Cited by 406 · see citing works

Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development.

Torres, M. A., Yang-Snyder, J., Purcell, S. M., DeMarais, A. A., McGrew, L. L., & Moon, R. T. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.5.1123 · Cited by 405 · see citing works

Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1

Li, L., Yuan, H., Weaver, C. D., Mao, J., Farr, G. H., Sussman, D. J., Jonkers, J., Kimelman, D., & Wu, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.15.4233 · Cited by 403 · see citing works

DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability

Kishida, S., Yamamoto, H., Hino, S.-I., Ikeda, S., Kishida, M., & Kikuchi, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4414 · Cited by 400 · see citing works

Conserved Patterns of Cell Movements during Vertebrate Gastrulation

Solnica-Krezel, L. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.016 · Cited by 391 · see citing works

The dishevelled protein is modified by wingless signaling in Drosophila.Preprint

Yanagawa, S.-I., van Leeuwen, F. N., Wodarz, A., Klingensmith, J., & Nusse, R. (1995) · Genes & Development · doi:10.1101/gad.9.9.1087 · Cited by 388 · see citing works

Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

Riggleman, B., Schedl, P. D., & Wieschaus, E. F. (1990) · Cell · doi:10.1016/0092-8674(90)90451-j · Cited by 386 · see citing works

Sizing up the heart: development redux in diseasePreprint

Olson, E. N., & Schneider, M. D. (2003) · Genes & Development · doi:10.1101/gad.1110103 · Cited by 382 · see citing works

The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos

Park, M., & Moon, R. T. (2002) · Nature Cell Biology · doi:10.1038/ncb716 · Cited by 381 · see citing works

dishevelled and armadillo act in the Wingless signalling pathway in Drosophila

Noordermeer, J. N., Klingensmith, J., Perrimon, N., & Nusse, R. (1994) · Nature · doi:10.1038/367080a0 · Cited by 378 · see citing works

Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila

Vinson, C., & Adler, P. N. (1987) · Nature · doi:10.1038/329549a0 · Cited by 366 · see citing works

Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Cong, F., Schweizer, L., & VARMUS, H. E. (2004) · Development · doi:10.1242/dev.01318 · Cited by 364 · see citing works

Neural tube closure requires Dishevelled-dependent convergent extension of the midline

Wallingford, J. B., & Harland, R. M. (2002) · Development · doi:10.1242/dev.00123 · Cited by 357 · see citing works

The wingless signalling pathway and the patterning of the wing margin in Drosophila

Couso, J. P., Bishop, S. A., & Arias, A. M. (1994) · Development · doi:10.1242/dev.120.3.621 · Cited by 356 · see citing works

Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos

Sheldahl, L. C., Slusarski, D. C., Pandur, P., Miller, J. R., Kühl, M., & Moon, R. T. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211094 · Cited by 350 · see citing works

Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?

Mlodzik, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02770-1 · Cited by 341 · see citing works

dishevelled is required during wingless signaling to establish both cell polarity and cell identity

Theisen, H., Purcell, J. M., Bennett, M. K., Kansagara, D., Syed, A., & Marsh, J. (1994) · Development · doi:10.1242/dev.120.2.347 · Cited by 339 · see citing works

Morphogenesis of the murine node and notochordal plate

Sulik, K., Dehart, D. B., Inagaki, T., Carson, J. L., Vrablic, T., Gesteland, K., & Schoenwolf, G. C. (1994) · Developmental Dynamics · doi:10.1002/aja.1002010309 · Cited by 338 · see citing works

Zebrafish Rho Kinase 2 Acts Downstream of Wnt11 to Mediate Cell Polarity and Effective Convergence and Extension Movements

Marlow, F., Topczewski, J., Sepich, D., & Solnica-Krezel, L. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00864-3 · Cited by 337 · see citing works

Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural developmentPreprint

Baker, J. C., Beddington, R. S. P., & Harland, R. M. (1999) · Genes & Development · doi:10.1101/gad.13.23.3149 · Cited by 337 · see citing works

Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4

Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L. A., Miller, W. E., Caron, M. G., Barak, L. S., Nusse, R., & Lefkowitz, R. J. (2003) · Science · doi:10.1126/science.1082808 · Cited by 334 · see citing works

Strabismus is asymmetrically localised and binds to Prickle and Dishevelled duringDrosophilaplanar polarity patterning

Bastock, R., Strutt, H. L., & Strutt, D. I. (2003) · Development · doi:10.1242/dev.00526 · Cited by 334 · see citing works

Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis

Altaba, A. R. I., & Jessell, T. M. (1992) · Development · doi:10.1242/dev.116.1.81 · Cited by 329 · see citing works

Components of wingless signalling in Drosophila

Siegfried, E., Wilder, E. L., & Perrimon, N. (1994) · Nature · doi:10.1038/367076a0 · Cited by 329 · see citing works

GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

Yost, C., Farr, G. H., Pierce, S. B., Ferkey, D. M., Chen, M. M., & Kimelman, D. (1998) · Cell · doi:10.1016/s0092-8674(00)81208-8 · Cited by 328 · see citing works

strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila

Wolff, T., & Rubin, G. M. (1998) · Development · doi:10.1242/dev.125.6.1149 · Cited by 321 · see citing works

Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells.

Wong, L., & Adler, P. N. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.1.209 · Cited by 317 · see citing works

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

Dominguez, I. M., Itoh, K., & Sokol, S. Y. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8498 · Cited by 316 · see citing works

Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction

Wharton, K. A. (2003) · Developmental Biology · doi:10.1006/dbio.2002.0869 · Cited by 315 · see citing works

PLANAR CELL POLARIZATION: An Emerging Model Points in the Right Direction

Klein, T. J., & Mlodzik, M. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.132806 · Cited by 311 · see citing works

Local and General Factors in the Development of “Pattern” in Rhodnius Prolixus (Hemiptera)

Wigglesworth, V. B. (1940) · Journal of Experimental Biology · doi:10.1242/jeb.17.2.180 · Cited by 308 · see citing works

The C‐terminal cytoplasmic Lys‐Thr‐X‐X‐X‐Trp motif in frizzled receptors mediates Wnt/β‐catenin signalling

Umbhauer, M., Djiane, A., Goisset, C., Penzo‐Méndez, A., Riou, J., Boucaut, J., & Shi, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.18.4944 · Cited by 303 · see citing works

Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis

Rothbächer, U., Laurent, M. N., Deardorff, M. A., Klein, P. S., Cho, K. W. Y., & Fraser, S. E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.1010 · Cited by 299 · see citing works

Essential role of non-canonical Wnt signalling in neural crest migration

Calisto, J. D., Araya, C., Marchant, L., Riaz, C. F., & Mayor, R. (2005) · Development · doi:10.1242/dev.01857 · Cited by 296 · see citing works

Changes in the shape of the developing vertebrate nervous system analyzed experimentally, mathematically and by computer simulation

Jacobson, A. G., & Gordon, R. (1976) · Journal of Experimental Zoology · doi:10.1002/jez.1401970205 · Cited by 295 · see citing works

Dishevelled Proteins Lead to Two Signaling Pathways

Li, L., Yuan, H., Xie, W., Mao, J., Caruso, A. M., McMahon, A., Sussman, D. J., & Wu, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.129 · Cited by 290 · see citing works

A Role of Dishevelled in Relocating Axin to the Plasma Membrane during Wingless Signaling

Cliffe, A., Hamada, F., & Bienz, M. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00370-1 · Cited by 289 · see citing works

Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system

Kaltschmidt, J. A., Davidson, C. M., Brown, N. H., & Brand, A. H. (1999) · Nature Cell Biology · doi:10.1038/71323 · Cited by 288 · see citing works

Wg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity

Tolwinski, N. S., Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S., & Wieschaus, E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00063-7 · Cited by 286 · see citing works

The Frizzled family: receptors for multiple signal transduction pathways.

Huang, H., & Klein, P. S. (2004) · Genome biology · doi:10.1186/gb-2004-5-7-234 · Cited by 283 · see citing works

Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization

Fagotto, F., Jho, E., Zeng, L., Kurth, T., Joos, T., Kaufmann, C. M., & Costantini, F. D. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.4.741 · Cited by 269 · see citing works

Frizzled-7 signalling controls tissue separation during Xenopus gastrulation

Winklbauer, R., Medina, A., Swain, R. K., & Steinbeisser, H. (2001) · Nature · doi:10.1038/35101621 · Cited by 263 · see citing works

Formation of Multiple Hearts in Mice following Deletion of β-catenin in the Embryonic Endoderm

Lickert, H., Kutsch, S., Kanzler, B., Tamai, Y., Taketo, M. M., & Kemler, R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00206-x · Cited by 260 · see citing works

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

Sun, T., Lu, B., Feng, J., Reinhard, C., Jan, Y. N., Fantl, W. J., & Williams, L. T. (2001) · Nature Cell Biology · doi:10.1038/35083016 · Cited by 255 · see citing works

Establishment of the Dorsal–Ventral Axis inXenopus Embryos Coincides with the Dorsal Enrichment of Dishevelled That Is Dependent on Cortical Rotation

Miller, J. R., Rowning, B. A., Larabell, C. A., Yang-Snyder, J., Bates, R. L., & Moon, R. T. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.2.427 · Cited by 254 · see citing works

Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division

Bellaı̈che, Y., Gho, M., Kaltschmidt, J. A., Brand, A. H., & Schweisguth, F. (2000) · Nature Cell Biology · doi:10.1038/35050558 · Cited by 252 · see citing works

Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye

Cooper, M. T. D., & Bray, S. J. (1999) · Nature · doi:10.1038/17395 · Cited by 249 · see citing works

Casein kinase 2 associates with and phosphorylates Dishevelled

Willert, K., Brink, M., Wodarz, A., Varmus, H., & Nusse, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3089 · Cited by 249 · see citing works

Dapper, a Dishevelled-Associated Antagonist of β-Catenin and JNK Signaling, Is Required for Notochord Formation

Cheyette, B. N. R., Waxman, J. S., Miller, J. R., Takemaru, K., Sheldahl, L. C., Khlebtsova, N., Fox, E. P., Earnest, T. N., & Moon, R. T. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00140-5 · Cited by 249 · see citing works

Interaction of Axin and Dvl‐2 proteins regulates Dvl‐2‐stimulated TCF‐dependent transcription

Smalley, M. J., Sara, E., Paterson, H., Naylor, S., Cook, D., Jayatilake, H., Fryer, L. G. D., Hutchinson, L., Fry, M., & Dale, T. C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.10.2823 · Cited by 247 · see citing works

Wnt signals from the neural tube block ectopic cardiogenesisPreprint

Tzahor, E., & Lassar, A. B. (2001) · Genes & Development · doi:10.1101/gad.871501 · Cited by 246 · see citing works

Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1

Luo, Z., Wang, Q., Zhou, J., Wang, J., Luo, Z., Liu, M., He, X., Wynshaw-Boris, A. J., Xiong, W., Lu, B., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00783-3 · Cited by 238 · see citing works

Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila

Gho, M., & Schweisguth, F. (1998) · Nature · doi:10.1038/30265 · Cited by 230 · see citing works

frizzled regulates mirror-symmetric pattern formation in the Drosophila eye

Zheng, L., Zhang, J., & Carthew, R. W. (1995) · Development · doi:10.1242/dev.121.9.3045 · Cited by 227 · see citing works

Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye

Fanto, M., & Mlodzik, M. (1999) · Nature · doi:10.1038/17389 · Cited by 225 · see citing works

Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus

McGrew, L. L., Hoppler, S., & Moon, R. T. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00160-3 · Cited by 225 · see citing works

Specification of the Anteroposterior Neural Axis through Synergistic Interaction of the Wnt Signaling Cascade withnogginandfollistatin

McGrew, L. L., Lai, C.-J., & Moon, R. T. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0027 · Cited by 223 · see citing works

Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling

Itoh, K., Brott, B. K., Bae, G.-U., Ratcliffe, M. J., & Sokol, S. Y. (2005) · Journal of Biology · doi:10.1186/jbiol20 · Cited by 221 · see citing works

Multiple functions of segment polarity genes in Drosophila

Perrimon, N., & Mahowald, A. P. (1987) · Developmental Biology · doi:10.1016/0012-1606(87)90061-3 · Cited by 220 · see citing works

Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding

Jenny, A., Reynolds-Kenneally, J., Das, G., Burnett, M., & Mlodzik, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1271 · Cited by 218 · see citing works

A divergent canonical WNT-signaling pathway regulates microtubule dynamics

Ciani, L., Krylova, O. Y., Smalley, M. J., Dale, T. C., & Salinas, P. C. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200309096 · Cited by 217 · see citing works

Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cellPreprint

Schlesinger, A., Shelton, C. A., Maloof, J., Meneghini, M., & Bowerman, B. A. (1999) · Genes & Development · doi:10.1101/gad.13.15.2028 · Cited by 217 · see citing works

<i>Xenopus</i>Dishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis

Wallingford, J. B., & Harland, R. M. (2001) · Development · doi:10.1242/dev.128.13.2581 · Cited by 217 · see citing works

Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila.

Eaton, S., Wepf, R. A., & Simons, K. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.5.1277 · Cited by 215 · see citing works

Casein kinase Iɛ in the Wnt pathway: Regulation of β-catenin function

Sakanaka, C., Leong, P. C., Xu, L., Harrison, S. D., & Williams, L. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12548 · Cited by 213 · see citing works

Dishevelled and Wnt signaling: is the nucleus the final frontier?

Habas, R., & Dawid, I. B. (2005) · Journal of Biology · doi:10.1186/jbiol22 · Cited by 211 · see citing works

Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila

Yanagawa, S.-I., Matsuda, Y., Lee, J.-S., Matsubayashi, H., Sese, S., Kadowaki, T., & Ishimoto, A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1733 · Cited by 202 · see citing works

TheXenopusreceptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling

Hikasa, H., Shibata, M., Hiratani, I., & Taira, M. (2002) · Development · doi:10.1242/dev.129.22.5227 · Cited by 198 · see citing works

Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye

Fanto, M., Weber, U., Strutt, D. I., & Mlodzik, M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00645-x · Cited by 193 · see citing works

The DIX domain targets dishevelled to actin stress fibres and vesicular membranes

Capelluto, D. G. S., Kutateladze, T. G., Habas, R., Finkielstein, C. V., He, X., & Overduin, M. (2002) · Nature · doi:10.1038/nature01056 · Cited by 190 · see citing works

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of β-catenin

Cong, F., & VARMUS, H. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307344101 · Cited by 189 · see citing works

Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled

Sokol, S. Y., Klingensmith, J., Perrimon, N., & Itoh, K. (1995) · Development · doi:10.1242/dev.121.6.1637 · Cited by 189 · see citing works

Regulation of cell polarity, radial intercalation and epiboly in Xenopus : novel roles for integrin and fibronectin

Marsden, M., & DeSimone, D. W. (2001) · Development · doi:10.1242/dev.128.18.3635 · Cited by 184 · see citing works

Isolation and Characterization of a Mouse Homolog of the Drosophila Segment Polarity Gene dishevelled

Sussman, D. J., Klingensmith, J., Salinas, P. C., Adams, P. S., Nusse, R., & Perrimon, N. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1297 · Cited by 183 · see citing works

Vangl2 Acts via RhoA Signaling to Regulate Polarized Cell Movements During Development of the Proximal Outflow Tract

Phillips, H. M., Murdoch, J. N., Chaudhry, B., Copp, A. J., & Henderson, D. J. (2005) · Circulation Research · doi:10.1161/01.res.0000154912.08695.88 · Cited by 182 · see citing works

Wnt Proteins Induce Dishevelled Phosphorylation via an LRP5/6- Independent Mechanism, Irrespective of Their Ability To Stabilize β-Catenin

González‐Sancho, J. M., Brennan, K. R., Castelo‐Soccio, L. A., & Brown, A. M. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4757-4768.2004 · Cited by 182 · see citing works

dishevelled is a component of the frizzled signaling pathway in Drosophila

Krasnow, R. E., Wong, L., & Adler, P. N. (1995) · Development · doi:10.1242/dev.121.12.4095 · Cited by 180 · see citing works

The genetic control of tissue polarity in Drosophila

Adler, P. N. (1992) · BioEssays · doi:10.1002/bies.950141103 · Cited by 177 · see citing works

PKCδ is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movementsPreprint

Kinoshita, N., Iioka, H., Miyakoshi, A., & Ueno, N. (2003) · Genes & Development · doi:10.1101/gad.1101303 · Cited by 173 · see citing works

Second Cysteine-rich Domain of Dickkopf-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled

Li, L., Mao, J., Sun, L., Liu, W., & Wu, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111131200 · Cited by 168 · see citing works

Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish developmentPreprint

Matsui, T., Raya, Á., Kawakami, Y., Callol-Massot, C., Capdevila, J., Rodrı́guez-Esteban, C., & Belmonte, J. C. I. (2005) · Genes & Development · doi:10.1101/gad.1253605 · Cited by 163 · see citing works

Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation

Tahinci, E., & Symes, K. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00206-9 · Cited by 162 · see citing works

naked cuticle targets dishevelled to antagonize Wnt signal transductionPreprint

Rousset, R., Mack, J. A., Wharton, K. A., Axelrod, J. D., Cadigan, K. M., Fish, M., Nusse, R., & Scott, M. P. (2001) · Genes & Development · doi:10.1101/gad.869201 · Cited by 160 · see citing works

Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.

Zheng, J., Wong, H. C., Mao, J., Nguyen, J. T., Srinivas, S., Zhang, W., Liu, B., Li, L., & Wu, D. (2000) · Nature Structural Biology · doi:10.1038/82047 · Cited by 157 · see citing works

Rethinking WNT signaling

Tolwinski, N. S., & Wieschaus, E. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.02.003 · Cited by 151 · see citing works

Characterization of Mouse Dishevelled (Dvl) Proteins in Wnt/Wingless Signaling Pathway

Lee, J.-S., Ishimoto, A., & Yanagawa, S.-I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21464 · Cited by 149 · see citing works

Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates

Moriguchi, T., Kawachi, K., Kamakura, S., Masuyama, N., Yamanaka, H., Matsumoto, K., Kikuchi, A., & Nishida, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30957 · Cited by 149 · see citing works

Asymmetric Localization of Frizzled and the Determination of Notch-Dependent Cell Fate in the Drosophila Eye

Strutt, D. I., Johnson, R. I., Cooper, K., & Bray, S. J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00841-2 · Cited by 148 · see citing works

A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment

Wakefield, J. G., Stephens, D. J., & Tavaré, J. M. (2003) · Journal of Cell Science · doi:10.1242/jcs.00273 · Cited by 144 · see citing works

Multiple Wnt Signaling Pathways Converge to Orient the Mitotic Spindle in Early C. elegans Embryos

Walston, T., Tuskey, C., Edgar, L. G., Hawkins, N., Ellis, G. C., Bowerman, B. A., Wood, W. B., & Hardin, J. D. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.10.008 · Cited by 144 · see citing works

DWnt4 Regulates Cell Movement and Focal Adhesion Kinase during Drosophila Ovarian Morphogenesis

Cohen, E. D., Mariol, M., Wallace, R. M. H., Weyers, J., Kamberov, Y. G., Pradel, J., & Wilder, E. L. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00142-9 · Cited by 142 · see citing works

Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled

Cong, F., Schweizer, L., & VARMUS, H. E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.2000-2011.2004 · Cited by 142 · see citing works

Differential stability of β-catenin along the animal-vegetal axis of the sea urchin embryo mediated by dishevelled

Weitzel, H. E., Illies, M. R., Byrum, C. A., Xu, R., Wikramanayake, A. H., & Ettensohn, C. A. (2004) · Development · doi:10.1242/dev.01152 · Cited by 141 · see citing works

Vertebrate Proteins Related to Drosophila Naked Cuticle Bind Dishevelled and Antagonize Wnt Signaling

Wharton, K. A., Zimmermann, G., Rousset, R., & Scott, M. P. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0238 · Cited by 140 · see citing works

Armadillo/β-catenin signals in the nucleus – proof beyond a reasonable doubt?

Bienz, M., & Clevers, H. (2003) · Nature Cell Biology · doi:10.1038/ncb0303-179 · Cited by 137 · see citing works

Regulation of the Wnt signaling pathway by disabled‐2 (Dab2)

Hocevar, B. A., Mou, F., Rennolds, J., Morris, S. M., Cooper, J. A., & Howe, P. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg286 · Cited by 134 · see citing works

Wnt-3a and Dvl Induce Neurite Retraction by Activating Rho-Associated Kinase

Kishida, S., Yamamoto, H., & Kikuchi, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4487-4501.2004 · Cited by 129 · see citing works

Inhibition of the Wnt Signaling Pathway by Idax, a Novel Dvl-Binding Protein

Hino, S.-I., Kishida, S., Michiue, T., Fukui, A., Sakamoto, I., Takada, S., Asashima, M., & Kikuchi, A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.330-342.2001 · Cited by 127 · see citing works

Purified Wnt‐5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

Schulte, G., Bryja, V., Rawal, N., Castelo‐Branco, G., Sousa, K. M., & Arenas, E. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.03022.x · Cited by 125 · see citing works

Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

Schweizer, L., & VARMUS, H. E. (2003) · BMC Cell Biology · doi:10.1186/1471-2121-4-4 · Cited by 125 · see citing works

Signaling Specificity by Frizzled Receptors in Drosophila

Boutros, M., Mihály, J., Bouwmeester, T., & Mlodzik, M. (2000) · Science · doi:10.1126/science.288.5472.1825 · Cited by 125 · see citing works

Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila

Lu, B., Usui, T., Uemura, T., Jan, L. Y., & Jan, Y. N. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80505-3 · Cited by 125 · see citing works

Dishevelled-1 Regulates Microtubule Stability

Krylova, O. Y., Messenger, M. J., & Salinas, P. C. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.1.83 · Cited by 120 · see citing works

Subcellular Localization and Signaling Properties of Dishevelled in Developing Vertebrate Embryos

Park, T. J., Gray, R. S., Sato, A., Habas, R., & Wallingford, J. B. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.062 · Cited by 119 · see citing works

Protein Phosphatase 2Cα Dephosphorylates Axin and Activates LEF-1-dependent Transcription

Strovel, E. T., Wu, D., & Sussman, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2399 · Cited by 118 · see citing works

Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus

Garriock, R. J., D'Agostino, S. L., Pilcher, K. C., & Krieg, P. A. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.12.013 · Cited by 114 · see citing works

Distinct PAR-1 Proteins Function in Different Branches of Wnt Signaling during Vertebrate Development

Ossipova, O., Dhawan, S., Sokol, S., & Green, J. B. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.011 · Cited by 113 · see citing works

Frodo interacts with Dishevelled to transduce Wnt signals

Gloy, J., Hikasa, H., & Sokol, S. Y. (2002) · Nature Cell Biology · doi:10.1038/ncb784 · Cited by 113 · see citing works

A Mutational Analysis of dishevelled in Drosophila Defines Novel Domains in the Dishevelled Protein as Well as Novel Suppressing Alleles of axin

Penton, A. L., Wodarz, A., & Nusse, R. (2002) · Genetics · doi:10.1093/genetics/161.2.747 · Cited by 112 · see citing works

A Positive Role for the PP2A Catalytic Subunit in Wnt Signal Transduction

Ratcliffe, M., Itoh, K., & Sokol, S. Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000639200 · Cited by 111 · see citing works

Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2

Klingensmith, J., Yang, Y., Axelrod, J. D., Beier, D. R., Perrimon, N., & Sussman, D. J. (1996) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00549-7 · Cited by 110 · see citing works

Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion

Tanaka, M., Kamo, T., Ota, S., & Sugimura, H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg088 · Cited by 108 · see citing works

Wnt-3a-dependent Cell Motility Involves RhoA Activation and Is Specifically Regulated by Dishevelled-2*[boxs]

Endo, Y., Wolf, V., Muraiso, K., Kamijo, K., Soon, L., Üren, A., Barshishat-Küpper, M., & Rubin, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406391200 · Cited by 106 · see citing works

Colocalization and Redistribution of Dishevelled and Actin during WNT-Induced Mesenchymal Morphogenesis

Torres, M. A., & Nelson, W. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.7.1433 · Cited by 104 · see citing works

JNK and ROKα function in the noncanonical Wnt/RhoA signaling pathway to regulate Xenopus convergent extension movements

Kim, G., & Han, J. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20262 · Cited by 103 · see citing works

Subcellular Localization of Frizzled Receptors, Mediated by Their Cytoplasmic Tails, Regulates Signaling Pathway Specificity

Wu, J., Klein, T. J., & Mlodzik, M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020158 · Cited by 101 · see citing works

Expanded characterization of the social interaction abnormalities in mice lacking Dvl1

Long, J. M., LaPorte, P., Paylor, R. E., & Wynshaw-Boris, A. J. (2004) · Genes Brain & Behavior · doi:10.1046/j.1601-183x.2003.00045.x · Cited by 98 · see citing works

The patterning and functioning of protrusive activity during convergence and extension of the Xenopus organiser

Keller, R. E., Shih, J., & Domingo, C. R. (1992) · Development · doi:10.1242/dev.116.supplement.81 · Cited by 96 · see citing works

Interaction of Dishevelled and Xenopus Axin-Related Protein Is Required for Wnt Signal Transduction

Itoh, K., Antipova, A. A., Ratcliffe, M., & Sokol, S. Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2228-2238.2000 · Cited by 95 · see citing works

Temporal colinearity in expression of anterior hox genes in developing chick embryos

Gaunt, S. J., & Strachan, L. (1996) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199611)207:3 · Cited by 91 · see citing works

PP2A:B56ϵ is required for Wnt/β-catenin signaling during embryonic development

Yang, J., Wu, J., Tan, C. L., & Klein, P. S. (2003) · Development · doi:10.1242/dev.00762 · Cited by 91 · see citing works

The ins and outs of Wingless signaling

Seto, E., & Bellen, H. J. (2003) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.11.004 · Cited by 89 · see citing works

Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled

Sokol, S. Y., Klingensmith, J., Perrrimon, N., & ltoh, K. (1995) · Development · doi:10.1242/dev.121.10.3487 · Cited by 86 · see citing works

Human Dishevelled Genes Constitute a DHR-Containing Multigene Family

Semënov, M. V., & Snyder, M. P. (1997) · Genomics · doi:10.1006/geno.1997.4713 · Cited by 81 · see citing works

SHAGGY and DISHEVELLED exert opposite effects on wingless and decapentaplegic expression and on positional identity in imaginal discs

Heslip, T. R., Theisen, H., Walker, H. A., & Marsh, J. L. (1997) · Development · doi:10.1242/dev.124.5.1069 · Cited by 75 · see citing works

Identification and characterization of a novel Dvl‐binding protein that suppresses Wnt signalling pathway

Oshita, A., Kishida, S., Kobayashi, H. H., Michiue, T., Asahara, T., Asashima, M., & Kikuchi, A. (2003) · Genes to Cells · doi:10.1111/j.1365-2443.2003.00692.x · Cited by 74 · see citing works

Regional requirements for Dishevelled signaling during Xenopus gastrulation: separable effects on blastopore closure, mesendoderm internalization and archenteron formation

Ewald, A. J., Peyrot, S. M., Tyszka, J. M., Fraser, S. E., & Wallingford, J. B. (2004) · Development · doi:10.1242/dev.01542 · Cited by 72 · see citing works

Characterization of Function of Three Domains in Dishevelled-1: DEP Domain is Responsible for Membrane Translocation of Dishevelled-1

Wei Jun, P. A. N., Pang, S., Huang, T., Guo, H., Wu, D., & Li, L. (2004) · Cell Research · doi:10.1038/sj.cr.7290232 · Cited by 72 · see citing works

Domains of Axin and Disheveled Required for Interaction and Function in Wnt Signaling

Julius, M. A., Schelbert, B., Hsu, W., Fitzpatrick, E., Jho, E., Fagotto, F., Costantini, F. D., & Kitajewski, J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3607 · Cited by 71 · see citing works

cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene

Pizzuti, A. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.7.953 · Cited by 68 · see citing works

Formins: processive cappers of growing actin filaments

Watanabe, N., & Higashida, C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.08.020 · Cited by 66 · see citing works

Functional Conservation of the Wnt Signaling Pathway Revealed by Ectopic Expression of Drosophila dishevelled in Xenopus

Rothbächer, U., Laurent, M. N., Blitz, I. L., Watabe, T., Marsh, J. L., & Cho, K. W. Y. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1249 · Cited by 62 · see citing works

Graded amounts of Xenopus dishevelled specify discrete anteroposterior cell fates in prospective ectoderm

Itoh, K., & Sokol, S. Y. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00627-2 · Cited by 59 · see citing works

Expression of the Sonic Hedgehog gene in human embryos with neural tube defects

Kirillova, I. A., Novikova, I., Augé, J., Audollent, S., Esnault, D., Encha‐Razavi, F., Lazjuk, G. I., Attié‐Bitach, T., & Vekemans, M. J. J. (2000) · Teratology · doi:10.1002/(sici)1096-9926(200005)61:5 · Cited by 48 · see citing works

Pax3 regulates morphogenetic cell behavior in vitro coincident with activation of a PCP/non-canonical Wnt-signaling cascade

Wiggan, O., & Hamel, P. A. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.3.531 · Cited by 46 · see citing works

Control of Intercalation Is Cell-Autonomous in the Notochord of Ciona intestinalis

Keys, D. N., Levine, M., Harland, R. M., & Wallingford, J. B. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0656 · Cited by 42 · see citing works

The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements

Sasai, N., Nakazawa, Y., Haraguchi, T., & Sasai, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1158 · Cited by 41 · see citing works

Rap2 is required for Wnt/β‐catenin signaling pathway in Xenopus early development

Choi, S., & Han, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600571 · Cited by 39 · see citing works

Rho guanine nucleotide exchange factor xNET1 implicated in gastrulation movements during Xenopus development

Miyakoshi, A., Ueno, N., & Kinoshita, N. (2004) · Differentiation · doi:10.1111/j.1432-0436.2004.07201004.x · Cited by 38 · see citing works

FGF signal regulates gastrulation cell movements and morphology through its target NRH

Chung, H. A., Hyodo‐Miura, J., Nagamune, T., & Ueno, N. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.02.030 · Cited by 34 · see citing works

Cell polarity during wound healing in an insect epidermis

Nübler‐Jung, K., Bonitz, R., & Sonnenschein, M. (1987) · Development · doi:10.1242/dev.100.1.163 · Cited by 32 · see citing works

Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway

Fan, S., Ramirez, S. H., Garcia, T. M., & Dewhurst, S. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.09.003 · Cited by 29 · see citing works

DSH-2 regulates asymmetric cell division in the early C. elegans somatic gonad

Chang, W., Lloyd, C. E., & Zarkower, D. A. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.03.005 · Cited by 26 · see citing works

WNT-mediated relocalization of dishevelled proteins

Steitz, S. A., Tsang, M., & Sussman, D. J. (1996) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02723007 · Cited by 25 · see citing works

Identification of EPS8 as a Dvl1-Associated Molecule

Inobe, M., Katsube, K., Miyagoe, Y., Nabeshima, Y., & Takeda, S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1782 · Cited by 22 · see citing works

STRUCTURAL BASIS OF THE RECOGNITION OF THE DISHEVELLED DEP DOMAIN IN THE WNT SIGNALING PATHWAY

Wong, H. C., & Zheng, J. (2000) · Worldwide Protein Data Bank · doi:10.2210/pdb1fsh/pdb · Cited by 16 · see citing works

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583 · see citing works

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568 · see citing works

Wnt signal transduction pathways

Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · see citing works

Mechanotransduction in development: a growing role for contractility

Wozniak, M. A., & Chen, C. S. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2592 · Cited by 821 · see citing works

Dishevelled: The hub of Wnt signaling

Gao, C., & Chen, Y. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.021 · Cited by 751 · see citing works

The PAR Proteins: Fundamental Players in Animal Cell Polarization

Goldstein, B., & Macara, I. G. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.10.007 · Cited by 746 · see citing works

β-Catenin destruction complex: insights and questions from a structural perspective

Kimelman, D., & Xu, W. (2006) · Oncogene · doi:10.1038/sj.onc.1210055 · Cited by 628 · see citing works

PDZ domains and their binding partners: structure, specificity, and modification

Lee, H., & Zheng, J. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-8 · Cited by 584 · see citing works

Planar Cell Polarity Signaling: From Fly Development to Human Disease

Simons, M., & Mlodzik, M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091432 · Cited by 570 · see citing works

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

Varelas, X., Miller, B. W., Sopko, R., Song, S., Gregorieff, A., Fellouse, F. A., Sakuma, R., Pawson, T. J., Hunziker, W., McNeill, H., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.007 · Cited by 571 · see citing works

Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms

Corbit, K. C., Shyer, A. E., Dowdle, W. E., Gaulden, J., Singla, V., & Reiter, J. F. (2008) · Nature Cell Biology · doi:10.1038/ncb1670 · Cited by 509 · see citing works

Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

Zeng, X., Huang, H., Tamai, K., Zhang, X., Harada, Y., Yokota, C., Almeida, K., Wang, J., Doble, B., Woodgett, J., et al. (2008) · Development · doi:10.1242/dev.013540 · Cited by 492 · see citing works

Immune Checkpoint Inhibitors: Basics and Challenges

Li, B., Chan, H. L., & Chen, P. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170804143706 · Cited by 473 · see citing works

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptorsPreprint

Grumolato, L., Liu, G., Mong, P. Y., Mudbhary, R., Biswas, R., Arroyave, R., Vijayakumar, S., Economides, A. N., & Aaronson, S. A. (2010) · Genes & Development · doi:10.1101/gad.1957710 · Cited by 471 · see citing works

β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis

Gurley, K. A., Rink, J. C., & Alvarado, A. S. (2008) · Science · doi:10.1126/science.1150029 · Cited by 469 · see citing works

Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells

Park, T. J., Mitchell, B. J., Abitua, P. B., Kintner, C. R., & Wallingford, J. B. (2008) · Nature Genetics · doi:10.1038/ng.104 · Cited by 448 · see citing works

Tissue/planar cell polarity in vertebrates: new insights and new questions

Wang, Y., & Nathans, J. (2007) · Development · doi:10.1242/dev.02772 · Cited by 442 · see citing works

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation

Wang, J., Hamblet, N. S., Mark, S., Dickinson, M. E., Brinkman, B. C., Segil, N., Fraser, S. E., Chen, P., Wallingford, J. B., & Wynshaw-Boris, A. J. (2006) · Development · doi:10.1242/dev.02347 · Cited by 355 · see citing works

Wnt signaling pathway: A comprehensive review

Hayat, R., Manzoor, M., & Hussain, A. (2022) · Cell Biology International · doi:10.1002/cbin.11797 · Cited by 356 · see citing works

The roles of cilia in developmental disorders and disease

Bisgrove, B. W., & Yost, H. J. (2006) · Development · doi:10.1242/dev.02595 · Cited by 348 · see citing works

The Role of Wnt Signaling in Physiological and Pathological Angiogenesis

Dejana, E. (2010) · Circulation Research · doi:10.1161/circresaha.110.223750 · Cited by 347 · see citing works

Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development

Etheridge, S. L., Ray, S., Li, S., Hamblet, N. S., Lijam, N., Tsang, M., Greer, J. M., Kardos, N., Wang, J., Sussman, D. J., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000259 · Cited by 325 · see citing works

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

Gray, R. S., Roszko, I., & Solnica‐Krezel, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.011 · Cited by 314 · see citing works

Wnt-5A/Ror2 Regulate Expression of XPAPC through an Alternative Noncanonical Signaling Pathway

Schambony, A., & Wedlich, D. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.02.016 · Cited by 310 · see citing works

Wnt Signaling from Development to Disease: Insights from Model SystemsPreprint

Cadigan, K. M., & Peifer, M. A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002881 · Cited by 302 · see citing works

Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances

Chen, X., Chu, Q., Shi, Q., Zeng, Y., Lu, J., & Li­, ­. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02142-w · Cited by 321 · see citing works

Wnt/Notch signalling and information processing during development

Hayward, P. C., Kalmár, T., & Arias, A. M. (2008) · Development · doi:10.1242/dev.000505 · Cited by 290 · see citing works

Role of Primary Cilia in the Pathogenesis of Polycystic Kidney Disease

Yoder, B. K. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006111215 · Cited by 288 · see citing works

Wnt signaling in neural circuit assembly

Salinas, P. C., & Zou, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125649 · Cited by 274 · see citing works

The Frizzled family of unconventional G-protein-coupled receptors

Schulte, G., & Bryja, V. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.09.001 · Cited by 253 · see citing works

Wnt signalling: conquering complexity

Wiese, K. E., Nusse, R., & van Amerongen, R. (2018) · Development · doi:10.1242/dev.165902 · Cited by 238 · see citing works

Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration

Nishita, M., Yoo, S. K., Nomachi, A., Kani, S., Sougawa, N., Ohta, Y., Takada, S., Kikuchi, A., & Minami, Y. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200607127 · Cited by 234 · see citing works

International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors

Schulte, G. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002931 · Cited by 227 · see citing works

The tau of MARK: a polarized view of the cytoskeleton

Matenia, D., & Mandelkow, E. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.03.008 · Cited by 228 · see citing works

Dishevelled: A masterful conductor of complex Wnt signals

Sharma, M., Castro‐Piedras, I., Simmons, G. E., Jr., & Pruitt, K. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.03.004 · Cited by 216 · see citing works

Dishevelled promotes axon differentiation by regulating atypical protein kinase C

Zhang, X., Zhu, J., Yang, G.-Y., Wang, Q.-J., Qian, L., Chen, Y.-M., Chen, F., Tao, Y., Hu, H.-S., Wang, T., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1603 · Cited by 220 · see citing works

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

Tauriello, D. V. F., Haegebarth, A., Kuper, I., Edelmann, M. J., Henraat, M., van Dijk, M. R., Kessler, B. M., Clevers, H. C., & Maurice, M. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.035 · Cited by 218 · see citing works

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

Piao, S., Lee, S., Kim, H., Yum, S., Stamos, J. L., Xu, Y., Lee, S. J., Lee, J., Oh, S., Han, J., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004046 · Cited by 212 · see citing works

RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt–β-Catenin Signaling

Cruciat, C., Dolde, C. E., de Groot, R. E. A., Ohkawara, B., Reinhard, C., Korswagen, H. C., & Niehrs, C. (2013) · Science · doi:10.1126/science.1231499 · Cited by 207 · see citing works

Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled

Grandy, D. K., Shan, J., Zhang, X., Rao, S., Akunuru, S., Li, H., Zhang, Y. H., Alpatov, I. V., Zhang, X. A., Lang, R. A., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009647 · Cited by 201 · see citing works

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

Jiang, X., Charlat, O., Zamponi, R., Yang, Y., & Cong, F. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.015 · Cited by 192 · see citing works

The PCP Pathway Instructs the Planar Orientation of Ciliated Cells in the Xenopus Larval Skin

Mitchell, B. J., Stubbs, J. L., Huisman, F. M., Taborek, P., Yu, C. C., & Kintner, C. R. (2009) · Current Biology · doi:10.1016/j.cub.2009.04.018 · Cited by 193 · see citing works

The Canonical Wnt/β-Catenin Signalling Pathway

Barker, N. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-249-6_1 · Cited by 192 · see citing works

Association of Dishevelled with the Clathrin AP-2 Adaptor Is Required for Frizzled Endocytosis and Planar Cell Polarity Signaling

Yu, A., Rual, J.-F. M., Tamai, K., Harada, Y., Vidal, M., He, X., & Kirchhausen, T. L. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.10.015 · Cited by 187 · see citing works

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

Bryja, V., Schulte, G., Rawal, N., Grahn, A., & Arenas, E. (2007) · Journal of Cell Science · doi:10.1242/jcs.03368 · Cited by 186 · see citing works

Cadherin Adhesion, Tissue Tension, and Noncanonical Wnt Signaling Regulate Fibronectin Matrix Organization

Dzamba, B. J., Jakab, K., Marsden, M., Schwartz, M. A., & DeSimone, D. W. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.008 · Cited by 181 · see citing works

Mechanism of activation of the Formin protein Daam1

Liu, W., Sato, A., Khadka, D., Bharti, R., Diaz, H., Runnels, L. W., & Habas, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707277105 · Cited by 173 · see citing works

Wnt signaling in macrophages: Augmenting and inhibiting mycobacteria-induced inflammatory responses

Schaale, K., Neumann, J., Schneider, D., Ehlers, S., & Reiling, N. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.11.004 · Cited by 168 · see citing works

Wnt Signaling Is Critical for Maladaptive Cardiac Hypertrophy and Accelerates Myocardial Remodeling

Malekar, P., Hagenmueller, M., Anyanwu, A., Buss, S. J., Streit, M. R., Weiss, C. S., Wolf, D., Riffel, J. H., Bauer, A. T., Katus, H. A., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.141127 · Cited by 165 · see citing works

Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis

Lai, S.-L., Chien, A. J., & Moon, R. T. (2009) · Cell Research · doi:10.1038/cr.2009.41 · Cited by 158 · see citing works

Regulation of Wnt/β‐catenin signaling by protein kinases

Verheyen, E. M., & Gottardi, C. J. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22019 · Cited by 158 · see citing works

Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signalingPreprint

Li, Y., Rankin, S. A., Sinner, D. I., Kenny, A. P., Krieg, P. A., & Zorn, A. M. (2008) · Genes & Development · doi:10.1101/gad.1687308 · Cited by 157 · see citing works

The Frizzled Extracellular Domain Is a Ligand for Van Gogh/Stbm during Nonautonomous Planar Cell Polarity Signaling

Wu, J., & Mlodzik, M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.08.004 · Cited by 155 · see citing works

Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling

Sheng, R., Kim, H., Lee, H., Xin, Y., Chen, Y., Tian, W., Cui, Y., Choi, J.-C., Doh, J., Han, J.-K., et al. (2014) · Nature Communications · doi:10.1038/ncomms5393 · Cited by 157 · see citing works

The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart

Brade, T., Männer, J., & KUHL, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.025 · Cited by 150 · see citing works

Role of the Wnt‐Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential

Dawson, K., Aflaki, M., & Nattel, S. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235382 · Cited by 147 · see citing works

PTK7 recruits dsh to regulate neural crest migration

Shnitsar, I., & Borchers, A. (2008) · Development · doi:10.1242/dev.023556 · Cited by 145 · see citing works

Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment

Xu, Y., Wang, C., Klabnik, J., & Donnell, J. O. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120231448 · Cited by 139 · see citing works

FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus

Wang, W., Li, X., Lee, M., Jun, S., Aziz, K. E., Feng, L., Tran, M. K., Li, N., McCrea, P. D., Park, J., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.031 · Cited by 136 · see citing works

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3

Lee, Y.-N., Gao, Y., & Wang, H. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.11.005 · Cited by 133 · see citing works

The role of primary cilia in neuronal function

Lee, J. H., & Gleeson, J. G. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.022 · Cited by 133 · see citing works

Wnt/Frizzled Signaling Controls C. elegans Gastrulation by Activating Actomyosin Contractility

Lee, J.-Y., Marston, D. J., Walston, T., Hardin, J. D., Halberstadt, A. I., & Goldstein, B. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.090 · Cited by 134 · see citing works

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

Berwick, D. C., & Harvey, K. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120122 · Cited by 131 · see citing works

Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients

Huang, Z., Huang, S., Song, T., Yin, Y., & Tan, C. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab070 · Cited by 131 · see citing works

HECT Domain-containing E3 Ubiquitin Ligase NEDD4L Negatively Regulates Wnt Signaling by Targeting Dishevelled for Proteasomal Degradation

Ding, Y., Zhang, Y., Xu, C., Tao, Q., & Chen, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.433185 · Cited by 128 · see citing works

Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes

Li, Y., & Dudley, A. T. (2009) · Development · doi:10.1242/dev.023820 · Cited by 127 · see citing works

Wnt Signaling in Mammalian Development: Lessons from Mouse GeneticsPreprint

Wang, J., Sinha, T., & Wynshaw-Boris, A. J. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007963 · Cited by 126 · see citing works

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

Jung, H., Kim, B.-G., Han, W., Lee, J. H., Cho, J.-Y., Park, W. S., Maurice, M. M., Han, J.-K., Lee, M. J., Finley, D. J., et al. (2013) · Oncogenesis · doi:10.1038/oncsis.2013.28 · Cited by 126 · see citing works

Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow

Maisonneuve, C., Guilleret, I., Vick, P., Weber, T., Andre, P., Beyer, T., Blum, M., & Constam, D. B. (2009) · Development · doi:10.1242/dev.038174 · Cited by 123 · see citing works

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

Sancho, R. M., Law, B. M. H., & Harvey, K. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp337 · Cited by 125 · see citing works

WGEF activates Rho in the Wnt–PCP pathway and controls convergent extension in Xenopus gastrulation

Tanegashima, K., Zhao, H., & Dawid, I. B. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.9 · Cited by 121 · see citing works

The crosstalk between Wnt/β-catenin signaling pathway with DNA damage response and oxidative stress: Implications in cancer therapy

Karimian, A., Majidinia, M., Baghi, H. B., & Yousefi, B. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.01.003 · Cited by 120 · see citing works

Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements

Kim, G., Her, J.-H., & Han, J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710188 · Cited by 115 · see citing works

Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models

Reynolds, K., Kumari, P., Rincon, L. S., Gu, R., Ji, Y., Kumar, S., & Zhou, C. J. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.037051 · Cited by 115 · see citing works

Emerging role of primary cilia as mechanosensors in osteocytes

Nguyen, A. M., & Jacobs, C. R. (2012) · Bone · doi:10.1016/j.bone.2012.11.016 · Cited by 113 · see citing works

The many roles of PTK7: A versatile regulator of cell–cell communication

Peradziryi, H., Tolwinski, N. S., & Borchers, A. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.12.019 · Cited by 111 · see citing works

Presynaptic Local Signaling by a Canonical Wingless Pathway Regulates Development of theDrosophilaNeuromuscular Junction

Miech, C., Pauer, H., He, X., & Schwarz, T. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0164-08.2008 · Cited by 112 · see citing works

Sequential Activation and Inactivation of Dishevelled in the Wnt/β-Catenin Pathway by Casein Kinases

Bernatík, O., Ganji, R. S., Dijksterhuis, J. P., Koník, P., Červenka, I., Polonio, T., Krejčı́, P., Schulte, G., & Bryja, V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169870 · Cited by 108 · see citing works

PDZ Domains as Drug Targets

Christensen, N. R., Čalyševa, J., Fernandes, E. F. A., Lüchow, S., Clemmensen, L. S., Haugaard‐Kedström, L. M., & Strømgaard, K. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201800143 · Cited by 110 · see citing works

Zebrafish Gastrulation: Cell Movements, Signals, and Mechanisms

Rohde, L. A., & Heisenberg, C. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)61004-3 · Cited by 107 · see citing works

Understanding the role of growth factors in embryonic development: insights from the lens

Lovicu, F. J., McAvoy, J. W., & de Iongh, R. U. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0339 · Cited by 105 · see citing works

Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation

Sato, A., Khadka, D., Liu, W., Bharti, R., Runnels, L. W., Dawid, I. B., & Habas, R. (2006) · Development · doi:10.1242/dev.02590 · Cited by 102 · see citing works

Dishevelled 2 Signaling Promotes Self-Renewal and Tumorigenicity in Human Gliomas

Pulvirenti, T., van der Heijden, M., Droms, L. A., Huse, J. T., Tabar, V. S., & Hall, A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1531 · Cited by 103 · see citing works

Frizzled/RYK mediated signalling in axon guidance

Bovolenta, P., Rodríguez, J., & Esteve, P. (2006) · Development · doi:10.1242/dev.02592 · Cited by 103 · see citing works

Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure

McGreevy, E. M., Vijayraghavan, D. S., Davidson, L. A., & Hildebrand, J. D. (2015) · Biology Open · doi:10.1242/bio.20149589 · Cited by 104 · see citing works

Molecular mechanisms of cell shape changes that contribute to vertebrate neural tube closure

Suzuki, M., Morita, H., & Ueno, N. (2012) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2012.01346.x · Cited by 100 · see citing works

Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled

Lee, H., Wang, N. X., Shi, D., & Zheng, J. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200902981 · Cited by 100 · see citing works

Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension

Ye, Z., Zhang, C., Tu, T., Sun, M., Liu, D., Lü, D., Feng, J., Yang, D., Liu, F., & Yan, X. (2013) · Nature Communications · doi:10.1038/ncomms3803 · Cited by 98 · see citing works

Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets

Jeon, S., Jeon, Y., Lim, J.-Y., Kim, Y., Cha, B., & Kim, W. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02070-1 · Cited by 97 · see citing works

An Integrated Proteomics and Metabolomics Approach for Defining Oncofetal Biomarkers in the Colorectal Cancer

Ma, Y., Zhang, P., Wang, F., Liu, W., Yang, J., & Qin, H. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e31824a9a8b · Cited by 98 · see citing works

Planar cell polarity signaling: coordination of cellular orientation across tissues

Singh, J., & Mlodzik, M. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.32 · Cited by 92 · see citing works

Cytomegalovirus subverts macrophage identity

Baasch, S., Giansanti, P., Kolter, J., Riedl, A., Forde, A. J., Runge, S., Zenke, S., Elling, R., Halenius, A., Brabletz, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.009 · Cited by 92 · see citing works

CKIɛ/discs overgrown Promotes Both Wnt-Fz/β-Catenin and Fz/PCP Signaling in Drosophila

Klein, T. J., Jenny, A., Djiane, A., & Mlodzik, M. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.030 · Cited by 94 · see citing works

The Interplay of the Aryl Hydrocarbon Receptor and β-Catenin Alters Both AhR-Dependent Transcription and Wnt/β-Catenin Signaling in Liver Progenitors

Procházková, J., Kabátková, M., Bryja, V., Umannová, L., Bernatík, O., Kozubı́k, A., Machala, M., & Vondráček, J. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr129 · Cited by 91 · see citing works

Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer

Kumar, S. U., Kumar, D. T., Ramamoorthy, S., Doss, C. G. P., & Zayed, H. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00391 · Cited by 87 · see citing works

HC-HA/PTX3 Purified From Amniotic Membrane Promotes BMP Signaling in Limbal Niche Cells to Maintain Quiescence of Limbal Epithelial Progenitor/Stem Cells

Chen, S., Han, B., Zhu, Y., Mahabole, M., Huang, J., Beebe, D. C., & Tseng, S. C. G. (2015) · Stem Cells · doi:10.1002/stem.2091 · Cited by 87 · see citing works

Planar Cell Polarity Signaling in the Drosophila Eye

Jenny, A. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385044-7.00007-2 · Cited by 83 · see citing works

The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility

Takagishi, M., Enomoto, A., Asai, N., Ushida, K., Watanabe, T., Hashimoto, T., Kato, T., Weng, L., Matsumoto, S., Asai, M., et al. (2012) · Nature Communications · doi:10.1038/ncomms1861 · Cited by 84 · see citing works

Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled‐3

Sutton, L. P., Honardoust, D., Mouyal, J., Rajakumar, N., & Rushlow, W. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04527.x · Cited by 86 · see citing works

Girdin, a Novel Actin‐Binding Protein, and Its Family of Proteins Possess Versatile Functions in the Akt and Wnt Signaling Pathways

Enomoto, A., PING, J., & Takahashi, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1377.016 · Cited by 87 · see citing works

Nuclear Dishevelled: An enigmatic role in governing cell fate and Wnt signaling

Boligala, G. P., Yang, M. V., van Wunnik, J. C., & Pruitt, K. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119305 · Cited by 20 · see citing works

Dishevelled: A masterful conductor of complex Wnt signals

Sharma, M., Castro‐Piedras, I., Simmons, G. E., Jr., & Pruitt, K. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.03.004 · Cited by 216 · see citing works

Subcellular Localization and Signaling Properties of Dishevelled in Developing Vertebrate Embryos

Park, T. J., Gray, R. S., Sato, A., Habas, R., & Wallingford, J. B. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.062 · Cited by 119 · see citing works

Dishevelled controls cell polarity during Xenopus gastrulation

Wallingford, J. B., Rowning, B. A., Vogeli, K. M., Rothbächer, U., Fraser, S. E., & Harland, R. M. (2000) · Nature · doi:10.1038/35011077 · Cited by 751 · see citing works

dishevelled is required during wingless signaling to establish both cell polarity and cell identity

Theisen, H., Purcell, J. M., Bennett, M. K., Kansagara, D., Syed, A., & Marsh, J. (1994) · Development · doi:10.1242/dev.120.2.347 · Cited by 339 · see citing works