The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Dynamic expression and essential functions of Hes7 in somite segmentation
Open accessAbstract
The basic helix–loop–helix (bHLH) gene Hes7 , a putative Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM). In Hes7 -null mice, somites are not properly segmented and their anterior–posterior polarity is disrupted. As a result, the somite derivatives such as vertebrae and ribs are severely disorganized. Although expression of Notch and its ligands is not affected significantly, the oscillator and Notch modulator lunatic fringe is expressed continuously throughout the mutant PSM. These results indicate that Hes7 controls the cyclic expression of lunatic fringe and is essential for coordinated somite segmentation.
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Cites
Induction of c-fos gene and protein by growth factors precedes activation of c-myc
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Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm
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Self-citationMaintenance of somite borders in mice requires the Delta homologue Dll1
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Notch signalling and the synchronization of the somite segmentation clock
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Disruption of the mouse RBP-J к gene results in early embryonic death
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Self-citationMice lacking both presenilin genes exhibitearlyembryonic patterningdefects
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Cited by
Autoinhibition with Transcriptional Delay
Lewis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00534-7 · Cited by 746
Notch Signaling in Vascular Development
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Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways
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Notch signaling in human development and disease
Penton, A. L., Leonard, L. D., & Spinner, N. B. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.01.010 · Cited by 332
Resolving early mesoderm diversification through single-cell expression profiling
Scialdone, A., Tanaka, Y., Jawaid, W., Moignard, V., Wilson, N. K., Macaulay, I. C., Marioni, J. C., & Göttgens, B. (2016) · Nature · doi:10.1038/nature18633 · Cited by 293
Metadata
- Authors
- Bessho, Y., Sakata, R., Komatsu, S., Shiota, K., Yamada, S., & Kageyama, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-10-15
- Volume
- 15
- Issue
- 20
- Pages
- 2642-2647
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2004325660
- Cited by
- 364
- References
- 27
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Bessho, Y., Sakata, R., Komatsu, S., Shiota, K., Yamada, S., & Kageyama, R. (2001). Dynamic expression and essential functions of Hes7 in somite segmentation. Genes & Development. https://doi.org/10.1101/gad.930601
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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